24 research outputs found

    Copper-mediated cross-coupling of functionalized arylmagnesium reagents with functionalized alkyl and benzylic halides

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    Functionalized arylmagnesium halides, prepared via an iodine−magnesium exchange, undergo a smooth cross-coupling reaction with functionalized primary alkyl iodides and benzylic bromides in the presence of CuCN·2LiCl, either in stoichiometric (with trimethyl phosphite as an additive) or catalytic quantities
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