Wunderkammer

I manufacture objects that confuse classification and cross boundaries. Part unicorn horn and part Narwhal tusk, these objects straddle categorical containers. My sculptures attempt to break free from inherited structures of knowledge and modes of seeing. The boxes and pedestals are akin to these imposed structures, though these traditional structures always fall just short of fulfilling their supposed function; these categorical containers slowly leak

A Distributed Intelligence Approach to Multidisciplinarity: Encouraging Divergent Thinking in Complex Science Issues in Society.

The scientific issues that face society today are increasingly complex, open-ended and tentative (Sadler, 2004). Finding solutions to these issues, not only requires an understanding of the science, but also, concurrently dealing with political, social, and economic dimensions that exist (Hodson, 2003). For example, 40 years after the first congressional hearing on climate change held by Al Gore in 1976, the 2012 Intergovernmental Panel on Climate Change (IPCC) report states that climate change is still getting worse, despite efforts by governments, businesses, social actors such as Non-Government Organizations, and scientists. With the top minds in the world, across all disciplines, backed with government and corporate funding pursuing the same goal of resolving human impact on climate change, why haven’t we resolved the situation? What strategies might be employed to increase effective action

Mg/Ca micro-distribution in foraminiferal test: implication of laboratory culture experiments

Abstrac

Social Behaviours under Anaerobic Conditions in Pseudomonas aeruginosa

Pseudomonas aeruginosa is well adapted to grow in anaerobic environments in the presence of nitrogen oxides by generating energy through denitrification. Environmental cues, such as oxygen and nitrogen oxide concentrations, are important in regulating the gene expression involved in this process. Recent data indicate that P. aeruginosa also employs cell-to-cell communication signals to control the denitrifying activity. The regulation of denitrification by these signalling molecules may control nitric oxide production. Nitric oxide, in turn, functions as a signalling molecule by activating certain regulatory proteins. Moreover, under denitrifying conditions, drastic changes in cell physiology and cell morphology are induced that significantly impact group behaviours, such as biofilm formation

Modulating the T Lymphocyte Immune Response via Secretome Produced miRNA: From Tolerance Induction to the Enhancement of the Anticancer Response

T cells are key mediators of graft tolerance/rejection, development of autoimmunity, and the anticancer response. Consequently, differentially modifying the T cell response is a major therapeutic target. Most immunomodulatory approaches have focused on cytotoxic agents, cytokine modulation, monoclonal antibodies, mitogen activation, adoptive cell therapies (including CAR-T cells). However, these approaches do not persistently reorient the systemic immune response thus necessitating continual therapy. Previous murine studies from our laboratory demonstrated that the adoptive transfer of polymer-grafted (PEGylated) allogeneic leukocytes resulted in the induction of a persistent and systemic tolerogenic state. Further analyses demonstrated that miRNA isolated from the secretome of polymer-modified or control allogeneic responses effectively induced either a tolerogenic (TA1 miRNA) or proinflammatory (IA1 miRNA) response both in vitro and in vivo that was both systemic and persistent. In a murine Type 1 diabetes autoimmune model, the tolerogenic TA1 therapeutic effectively attenuated the disease process via the systemic upregulation of regulatory T cells while simultaneously downregulating T effector cells. In contrast, the proinflammatory IA1 therapeutic enhanced the anticancer efficacy of naïve PBMC by increasing inflammatory T cells and decreasing regulatory T cells. The successful development of this secretome miRNA approach may prove useful treating both autoimmune diseases and cancer