Spent fuel sabotage test program, characterization of aerosol dispersal : interim final report.

This multinational, multi-phase spent fuel sabotage test program is quantifying the aerosol particles produced when the products of a high energy density device (HEDD) interact with and explosively particulate test rodlets that contain pellets of either surrogate materials or actual spent fuel. This program provides source-term data that are relevant to plausible sabotage scenarios in relation to spent fuel transport and storage casks and associated risk assessments. We present details and significant results obtained from this program from 2001 through 2007. Measured aerosol results include: respirable fractions produced; amounts, nuclide content, and produced particle size distributions and morphology; measurements of volatile fission product species enhanced sorption--enrichment factors onto respirable particles; and, status on determination of the spent fuel ratio, SFR, needed for scaling studies. Emphasis is provided on recent Phase 3 tests using depleted uranium oxide pellets plus non-radioactive fission product dopants in surrogate spent fuel test rodlets, plus the latest surrogate cerium oxide results and aerosol laboratory supporting calibration work. The DUO{sub 2}, CeO{sub 2}, plus fission product dopant aerosol particle results are compared with available historical data. We also provide a status review on continuing preparations for the final Phase 4 in this program, tests using individual short rodlets containing actual spent fuel from U.S. PWR reactors, with both high- and lower-burnup fuel. The source-term data, aerosol results, and program design have been tailored to support and guide follow-on computer modeling of aerosol dispersal hazards and radiological consequence assessments. This spent fuel sabotage, aerosol test program was performed primarily at Sandia National Laboratories, with support provided by both the U.S. Department of Energy and the Nuclear Regulatory Commission. This program has significant input from, and is cooperatively supported and coordinated by both the U.S. and international program participants in Germany, France, and others, as part of the International Working Group for Sabotage Concerns of Transport and Storage Casks (WGSTSC)

Spent fuel sabotage aerosol ratio program : FY 2004 test and data summary.

This multinational, multi-phase spent fuel sabotage test program is quantifying the aerosol particles produced when the products of a high energy density device (HEDD) interact with and explosively particulate test rodlets that contain pellets of either surrogate materials or actual spent fuel. This program has been underway for several years. This program provides data that are relevant to some sabotage scenarios in relation to spent fuel transport and storage casks, and associated risk assessments. The program also provides significant technical and political benefits in international cooperation. We are quantifying the Spent Fuel Ratio (SFR), the ratio of the aerosol particles released from HEDD-impacted actual spent fuel to the aerosol particles produced from surrogate materials, measured under closely matched test conditions, in a contained test chamber. In addition, we are measuring the amounts, nuclide content, size distribution of the released aerosol materials, and enhanced sorption of volatile fission product nuclides onto specific aerosol particle size fractions. These data are the input for follow-on modeling studies to quantify respirable hazards, associated radiological risk assessments, vulnerability assessments, and potential cask physical protection design modifications. This document includes an updated description of the test program and test components for all work and plans made, or revised, during FY 2004. It also serves as a program status report as of the end of FY 2004. All available test results, observations, and aerosol analyses plus interpretations--primarily for surrogate material Phase 2 tests, series 2/5A through 2/9B, using cerium oxide sintered ceramic pellets are included. Advanced plans and progress are described for upcoming tests with unirradiated, depleted uranium oxide and actual spent fuel test rodlets. This spent fuel sabotage--aerosol test program is coordinated with the international Working Group for Sabotage Concerns of Transport and Storage Casks (WGSTSC) and supported by both the U.S. Department of Energy and the Nuclear Regulatory Commission

Untersuchungen zur krebserzeugenden Wirkung polychlorierter Dibenzodioxine. T. B: Mechanismen der Apoptosehemmung durch Dioxine in Hepatozytenkulturen Schlussbericht

Available from TIB Hannover: DtF QN1(68,30) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman

Die Nutzung hepatischer Funktionen fuer in vitro-Verfahren zur Pruefung von Stoffen mit dem Ziel der Einsparung von Tierversuchen. Validierung von in vitro Metabolisierungssystemen mit kryokonservierten Hepatozyten aus Mensch, Ratte und Maus Abschlussbericht

SIGLEAvailable from TIB Hannover: DtF QN1(70,55) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman

In vitro-Mikrokerntest in der Routinepruefung auf gentoxische Eigenschaften. Teilprojekt 5: Validierung einer Standardmethodenbeschreibung Schlussbericht

Available from TIB Hannover: DtF QN1(77,34) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung und Forschung (BMBF), Bonn (Germany)DEGerman

Entwicklung und Evaluierung von Methoden zur praedikativen Risikoabschaetzung durch toxikokinetische Untersuchungen Schlussbericht

Available from TIB Hannover: F98B1359 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman

Aerosol-Sensor: Echtzeit-Bestimmung von Aerosol-Massengroessenverteilungen mittels filtrierender Quarzoszillatoren Schlussbericht

Copy held by FIZ Karlsruhe; available from UB/TIB Hannover / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Die Wirkung der Vitamin A-Saeure auf multizellulaere Sphaeroide

Vitamin A-acid (retinoic acid) has multiple influences on biological systems. In this study the effect on gap junction-mediated intercellular communication of cultured cells is investigated. To avoid cell line-specific and species-specific effects a human amniotic cell line (FL-cells) and a mouse fibroblast cell line (SV40-3T3-cells) are used. Both can be enhanced in their rate of cell-cell communication by low concentrations of retinoic acid (0,1 nM and 0,1 #mu#M). Adding 0,1 mM retinoic acid decreases intercellular communication. These alterations influence other cellular parameters. The investigations are carried out with cells grown as monolayers and with three dimensional multicellular aggregates, so called spheroids. The influence of intercellular communication is only visable in spheroids: here modulations of cell coupling lead to altered cyclic Adenosinmonophosphat (cAMP) distribution, altered cell cycle distribution and changes in DNA-synthesis patterns. Possible gradients of cAMP and cell cycle distribution are flattened in general by enhanced intercellular communication. Decreased cell coupling produces gradients or steepens existing ones. Monolayers do not show these dependencies. Investigations of the DNA-synthesis indicate a possible clinical relevance for combined therapies in cancer cure. These results underline the importance of intercellular communication as well as the necessity of an appropriate cell culture system. (orig.)SIGLEAvailable from TIB Hannover: ZA 5141(5308) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Funktion, Morphologie und Kinetik von Lungenmakrophagen bei Schadstoffexposition und Infektion. Teilvorhaben 1 - 4 Abschlussbericht

This final report contains the findings of the four sub-projects: 1. Response of the macrophage system of the lungs to pollutant exposure and infection; 2. Functional morphology of lung macrophages after pollutant exposure and infection; 3. Pollutant exposure of the experimental animals and investigation of the transport function of alveolar macrophages; 4. Immunological function and functional morphology of human alveolar macrophages after ozone exposure and infection. (Orig./MG)Der vorliegende Abschlussbericht zeigt die Ergebnisse der 4 Teilvorhaben auf. Sie lauten wie folgt: Das Makrophagensystem der Lunge bei Schadstoffbelastung und Infektion; Funktionelle Morphologie von Lungenmakrophagen nach Schadstoffexposition und Infektion; Schadstoffexposition der Versuchstiere und Untersuchung der Transportfunktion alveolaerer Makrophagen; Immunologische Funktion und funktionelle Morphologie von humanen Alveolarmakrophagen bei Ozonexposition und InfektAvailable from TIB Hannover: F98B573+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman

Luftgetragene Halogenkohlenwasserstoffe in der Umwelt und ihr Abbau zu Produkten mit herbizider Wirkung Abschlussbericht

During the execution of this project proof was obtained that C_2 halocarbon compounds and their atmospheric degradation products are implicated in the development of tree damage. The air pollutants were identified by gas chromatography. Cell culture experiments confirmed the phytotoxicity of the resulting halogenated acetic acid derivatives. (EF)Im Verlaufe der Durchfuehrung des vorliegenden Projektes konnte festgestellt werden, dass C_2-Halogenkohlenwasserstoffe und daraus gebildete atmosphaerische Abbauprodukte an der Ausloesung von Baumschaeden beteiligt sind. Die Luftschadstoffe wurden gaschromatographisch ermittelt. Anhand von Zellkulturexperimenten konnte die Phytotoxizitaet der sich bildenden Halogenessigsaeurederivate nachgewiesen werden. (EF)SIGLEAvailable from TIB Hannover: F94B0637+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Forschung und Technologie (BMFT), Bonn (Germany)DEGerman