Periprosthetic osteolysis after total hip replacement: molecular pathology and clinical management

Periprosthetic osteolysis is a serious complication of total hip replacement (THR) in the medium to long term. Although often asymptomatic, osteolysis can lead to prosthesis loosening and periprosthetic fracture. These complications cause significant morbidity and require complex revision surgery. Here, we review advances in our understanding of the cell and tissue response to particles produced by wear of the articular and non-articular surfaces of prostheses. We discuss the molecular and cellular regulators of osteoclast formation and bone resorptive activity, a better understanding of which may lead to pharmacological treatments for periprosthetic osteolysis. We describe the development of imaging techniques for the detection and measurement of osteolysis around THR prostheses, which enable improved clinical management of patients, provide a means of evaluating outcomes of non-surgical treatments for periprosthetic osteolysis, and assist in pre-operative planning for revision surgery. Finally, there have been advances in the materials used for bearing surfaces to minimise wear, and we review the literature regarding the performance of these new materials to date.Donald W. Howie, Susan D. Neale, David R. Haynes, Oksana T. Holubowycz, Margaret A. McGee, Lucian B. Solomon, Stuart A. Callary, Gerald J. Atkins, David M. Findla

[Social medical themes and the health intervention: violence against women in the professional's discourse].

This study deals with violence against women as a health care matter. It was part of a research in public services of São Paulo (Brazil), including the prevalence of violence among users from 15 to 49 years old; the study of their medical records; the description of the services; and interview with 50 professionals, focusing the routine and the ideals of health work, the perception on the existence of violence cases, the offer of assistance or its obstacles and the representations on violence. This article analyses the content of the professional narratives and uses the other data to characterise the assistance context. Confirming the literature, violence was almost always regarded as a relevant problem but outside the professional's intervention boundaries. Isolated actions and in a personal basis were reported. Fear and professional impotence were mentioned, but none positive aspect for potential interventions. The professionals showed lack of knowledge of specialized reference services. In conclusion, the difficulties in the acceptance of violence cases should be worked in three dimensions: the narrow definition of professionals' competence that excludes violence as an object; the absence of technological definitions for professional actions; and effective support in their services