4,233 research outputs found
Measuring the Mass of the Lightest Chargino at the CERN LHC
Results are presented of a feasibility study of techniques for measuring the
mass of the lightest chargino at the CERN LHC. These results suggest that for
one particular mSUGRA model a statistically significant chargino signal can be
identified and the chargino mass reconstructed with a precision of order 11%
for of order 100 fb-1 of data.Comment: 6 pages, 5 figures. To appear in the proceedings of the workshop: Les
Houches 2003: Physics at TeV Scale Collider
Photomaps: A Visual Taxonomy
Photomaps: A visual taxonom
Ras/Raf-1/MAPK pathway mediates response to tamoxifen but not chemotherapy in breast cancer patients
<b>Purpose</b>: The expression and activation of the Ras/Raf-1/mitogen-activated protein kinase (MAPK) pathway plays an important role in the development and progression of cancer, and may influence response to treatments such as tamoxifen and chemotherapy. In this study we investigated whether the expression and activation of the key components of this pathway influenced clinical outcome, to test the hypothesis that activation of the MAPK pathway drives resistance to tamoxifen and chemotherapy in women with breast cancer.
<b>Experimental Design</b>: Breast tumors from patients at the Glasgow Royal Infirmary and others treated within the BR9601 trial were analyzed for expression of the three Ras isoforms, total Raf-1, active and inactive forms of Raf-1 [pRaf(ser338) and pRaf(ser259), respectively], MAPK, and phospho-MAPK using an immunohistochemical approach. Analyses were done with respect to disease free-survival and overall survival.
<b>Results</b>: Expression and activation of the Ras pathway was associated with loss of benefit from treatment with tamoxifen but not chemotherapy. Overexpression of pRaf(ser338) was associated with shortened disease-free and overall survival time in univariate analyses. Multivariate analysis suggested pRaf(ser338) was independent of known prognostic markers in predicting outcome following tamoxifen treatment (<i>P</i>=0.03).
<b>Conclusion</b>: This study suggests that activation of the Ras pathway predicts for poor outcome on tamoxifen but not chemotherapy, and identifies pRaf(ser338) as a potential marker of resistance to estrogen receptor–targeted therapy. In addition, it suggests that expression of pRaf(ser338) could identify patients for whom tamoxifen alone is insufficient adjuvant systemic therapy, but for whom the addition of chemotherapy may be of benefit
Processing Multi-Spectral Scanning Electron Microscopy Images for Quantitative Microfabric Analysis
Multi-spectral image analysis is a powerful method to characterise quantitatively the mineralogy and microfabric of soils, sediments, and other particulate materials. Backscattered scanning electron microscope (SEM) images of polished, resin-impregnated samples are grouped with the corresponding X-ray elemental maps using classification methods commonly used in remote sensing. However, the resulting mineral-segmented images require processing to render them suitable for quantification. In the past, this has been done subjectively and interactively, but the new objective methods described in this paper largely eliminate this subjectivity. An intensity gradient magnitude image of the original backscattered electron image is used as the basis of an interactive erosion and dilation sequence to generate skeleton outlines defining the edges of the mineral grains. The areas defined within the skeleton areas are then classified as a particular mineral according to the predominant feature in the corresponding mineral-segmented image. Subsequent processing tackles the problems of \u27holes\u27 defined by the skeleton outlines, and the over-segmentation associated with certain classes of mineral grain. Further methods to deal with particles made up of more than one mineral are considered.
The matrix and porosity information is recombined to generate an image suitable for analysis using feature size statistics or general orientation analysis. The techniques described can be combined to permit batch processing of images. Applications of the techniques are illustrated on a soil from the East Anglian Breckland
Domestic ventilation rates, indoor humidity and dust mite allergens : are our homes causing the asthma pandemic?
This paper is concerned with historical changes in domestic ventilation rates, relative humidity and the associated risk of house dust mite colonization. A controlled trial evaluated allergen and water vapour control measures on the level of house dust mite (HDM) Der p1 allergen and indoor humidity, concurrently with changes in lung function in 54 subjects who completed the protocol. Mechanical heat recovery ventilation units significantly reduced moisture content in the active group, while HDM allergen reservoirs in carpets and beds were reduced by circa 96%. Self reported health status confirmed a significant clinical improvement in the active group. The study can form the basis for assessing minimum winter ventilation rates that can suppress RH below the critical ambient equilibrium humidity of 60% and thus inhibit dust mite colonization and activity in temperate and maritime in' uenced climatic regions
Sqrt{shat}_{min} resurrected
We discuss the use of the variable sqrt{shat}_{min}, which has been proposed
in order to measure the hard scale of a multi parton final state event using
inclusive quantities only, on a SUSY data sample for a 14 TeV LHC. In its
original version, where this variable was proposed on calorimeter level, the
direct correlation to the hard scattering scale does not survive when effects
from soft physics are taken into account. We here show that when using
reconstructed objects instead of calorimeter energy and momenta as input, we
manage to actually recover this correlation for the parameter point considered
here. We furthermore discuss the effect of including W + jets and t tbar+jets
background in our analysis and the use of sqrt{shat}_{min} for the suppression
of SM induced background in new physics searches.Comment: 23 pages, 9 figures; v2: 1 figure, several subsections and references
as well as new author affiliation added. Corresponds to published versio
Measurements of Scintillation Efficiency and Pulse-Shape for Low Energy Recoils in Liquid Xenon
Results of observations of low energy nuclear and electron recoil events in
liquid xenon scintillator detectors are given. The relative scintillation
efficiency for nuclear recoils is 0.22 +/- 0.01 in the recoil energy range 40
keV - 70 keV. Under the assumption of a single dominant decay component to the
scintillation pulse-shape the log-normal mean parameter T0 of the maximum
likelihood estimator of the decay time constant for 6 keV < Eee < 30 keV
nuclear recoil events is equal to 21.0 ns +/- 0.5 ns. It is observed that for
electron recoils T0 rises slowly with energy, having a value ~ 30 ns at Eee ~
15 keV. Electron and nuclear recoil pulse-shapes are found to be well fitted by
single exponential functions although some evidence is found for a double
exponential form for the nuclear recoil pulse-shape.Comment: 11 pages, including 5 encapsulated postscript figure
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Calcium puffs are generic InsP<sub>3</sub>-activated elementary calcium signals and are downregulated by prolonged hormonal stimulation to inhibit cellular calcium responses
Elementary Ca2+ signals, such as "Ca2+ puffs", which arise from the activation of inositol 1,4,5-trisphosphate receptors, are building blocks for local and global Ca2+ signalling. We characterized Ca2+ puffs in six cell types that expressed differing ratios of the three inositol 1,4,5-trisphosphate receptor isoforms. The amplitudes, spatial spreads and kinetics of the events were similar in each of the cell types. The resemblance of Ca2+ puffs in these cell types suggests that they are a generic elementary Ca2+ signal and, furthermore, that the different inositol 1,4,5-trisphosphate isoforms are functionally redundant at the level of subcellular Ca2+ signalling. Hormonal stimulation of SH-SY5Y neuroblastoma cells and HeLa cells for several hours downregulated inositol 1,4,5-trisphosphate expression and concomitantly altered the properties of the Ca2+ puffs. The amplitude and duration of Ca2+ puffs were substantially reduced. In addition, the number of Ca2+ puff sites active during the onset of a Ca2+ wave declined. The consequence of the changes in Ca2+ puff properties was that cells displayed a lower propensity to trigger regenerative Ca2+ waves. Therefore, Ca2+ puffs underlie inositol 1,4,5-trisphosphate signalling in diverse cell types and are focal points for regulation of cellular responses
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