Evaluating complementary medicine: methodological challenges of randomised controlled trials

Complementary medicine has a different philosophy from conventional medicine, presenting challenges to research methodology. Rigorous evaluation of complementary medicine could provide much needed evidence of its effectiveness. Good design of randomised controlled trials will avoid invalid results and misrepresentation of the holistic essence of complementary medicine. Practitioners need to be recognised as a component in or contributor to complementary treatment. Both specific and non-specific outcome measures with long follow up are needed to adequately encompass the essence of complementary medicine

Phase Transition in Matched Formulas and a Heuristic for Biclique Satisfiability

A matched formula is a CNF formula whose incidence graph admits a matching which matches a distinct variable to every clause. We study phase transition in a context of matched formulas and their generalization of biclique satisfiable formulas. We have performed experiments to find a phase transition of property "being matched" with respect to the ratio $m/n$ where $m$ is the number of clauses and $n$ is the number of variables of the input formula $\varphi$. We compare the results of experiments to a theoretical lower bound which was shown by Franco and Gelder (2003). Any matched formula is satisfiable, moreover, it remains satisfiable even if we change polarities of any literal occurrences. Szeider (2005) generalized matched formulas into two classes having the same property -- var-satisfiable and biclique satisfiable formulas. A formula is biclique satisfiable if its incidence graph admits covering by pairwise disjoint bounded bicliques. Recognizing if a formula is biclique satisfiable is NP-complete. In this paper we describe a heuristic algorithm for recognizing whether a formula is biclique satisfiable and we evaluate it by experiments on random formulas. We also describe an encoding of the problem of checking whether a formula is biclique satisfiable into SAT and we use it to evaluate the performance of our heuristicComment: Conference version submitted to SOFSEM 2018 (https://beda.dcs.fmph.uniba.sk/sofsem2019/) 18 pages(17 without refernces), 3 figures, 8 tables, an algorithm pseudocod

Ras/Raf-1/MAPK pathway mediates response to tamoxifen but not chemotherapy in breast cancer patients

<b>Purpose</b>: The expression and activation of the Ras/Raf-1/mitogen-activated protein kinase (MAPK) pathway plays an important role in the development and progression of cancer, and may influence response to treatments such as tamoxifen and chemotherapy. In this study we investigated whether the expression and activation of the key components of this pathway influenced clinical outcome, to test the hypothesis that activation of the MAPK pathway drives resistance to tamoxifen and chemotherapy in women with breast cancer. <b>Experimental Design</b>: Breast tumors from patients at the Glasgow Royal Infirmary and others treated within the BR9601 trial were analyzed for expression of the three Ras isoforms, total Raf-1, active and inactive forms of Raf-1 [pRaf(ser338) and pRaf(ser259), respectively], MAPK, and phospho-MAPK using an immunohistochemical approach. Analyses were done with respect to disease free-survival and overall survival. <b>Results</b>: Expression and activation of the Ras pathway was associated with loss of benefit from treatment with tamoxifen but not chemotherapy. Overexpression of pRaf(ser338) was associated with shortened disease-free and overall survival time in univariate analyses. Multivariate analysis suggested pRaf(ser338) was independent of known prognostic markers in predicting outcome following tamoxifen treatment (<i>P</i>=0.03). <b>Conclusion</b>: This study suggests that activation of the Ras pathway predicts for poor outcome on tamoxifen but not chemotherapy, and identifies pRaf(ser338) as a potential marker of resistance to estrogen receptor–targeted therapy. In addition, it suggests that expression of pRaf(ser338) could identify patients for whom tamoxifen alone is insufficient adjuvant systemic therapy, but for whom the addition of chemotherapy may be of benefit

Pulse-Shape Discrimination of CaF2(Eu)

We measured the decay time of the scintillation pulses produced by electron and nuclear recoils in CaF2(Eu) by a new fitting method. In the recoil energy region 5-30 keVee, we found differences of the decay time between electron and nuclear recoil events. In the recoil energy region above 20 keVee, we found that the decay time is independent of the recoil energy.Comment: 10 pages, 4 figure

The Evaluation of Equity-Focused Community Coalitions: A Review of the Empirical Literature

Conducting evaluation and research with community coalitions involved in health equity initiatives is inherently complex. In this paper we provide a review and synthesis of the empirical literature on the evaluation of equity-focused community coalitions. We explore issues, challenges, and barriers experienced by evaluators, as well as techniques and approaches that were considered beneficial. Our review identified 11 peer reviewed articles, from which we identified seven overlapping themes: (1) framing equity in the evaluation process, (2) use of multiple theoretical frameworks, (3) use of systems-focused approaches, (4) strategic use of intersectoral partnerships and collaborations, (5) intentional communication and building trusting relationships, (6) challenges dedicating purposeful time to the work, and (7) issues of cultural and contextual clarity and responsiveness. Our findings point to a significant focus on context, history, learning, communication, relationships, and power. The cultural complexity and historical scope of each context, diversity of stakeholders, and enormity of the systemic issues involved, shape and challenge the evaluation and research process in fundamental ways, requiring a creative and kinetic thinking -- a shifting from methodological certainty to an acknowledged uncertainty, where mixing, blending and the innovative use of approaches and theories becomes a way of moving beyond the colonizing past

Supersymmetric particle mass measurement with invariant mass correlations

The kinematic end-point technique for measuring the masses of supersymmetric particles in R-Parity conserving models at hadron colliders is re-examined with a focus on exploiting additional constraints arising from correlations in invariant mass observables. The use of such correlations is shown to potentially resolve the ambiguity in the interpretation of quark+lepton end-points and enable discrimination between sequential two-body and three-body lepton-producing decays. The use of these techniques is shown to improve the SUSY particle mass measurement precision for the SPS1a benchmark model by at least 20-30% compared to the conventional end-point technique.Comment: 29 pages, 23 .eps figures, JHEP3 style; v2 adds some references and small clarifications to text; v3 adds some more clarifications to the tex

Domestic ventilation rates, indoor humidity and dust mite allergens : are our homes causing the asthma pandemic?

This paper is concerned with historical changes in domestic ventilation rates, relative humidity and the associated risk of house dust mite colonization. A controlled trial evaluated allergen and water vapour control measures on the level of house dust mite (HDM) Der p1 allergen and indoor humidity, concurrently with changes in lung function in 54 subjects who completed the protocol. Mechanical heat recovery ventilation units significantly reduced moisture content in the active group, while HDM allergen reservoirs in carpets and beds were reduced by circa 96%. Self reported health status confirmed a significant clinical improvement in the active group. The study can form the basis for assessing minimum winter ventilation rates that can suppress RH below the critical ambient equilibrium humidity of 60% and thus inhibit dust mite colonization and activity in temperate and maritime in' uenced climatic regions

Supersymmetric particle mass measurement with the boost-corrected contransverse mass

A modification to the contransverse mass (MCT) technique for measuring the masses of pair-produced semi-invisibly decaying heavy particles is proposed in which MCT is corrected for non-zero boosts of the centre-of-momentum (CoM) frame of the heavy states in the laboratory transverse plane. Lack of knowledge of the mass of the CoM frame prevents exact correction for this boost, however it is shown that a conservative correction can nevertheless be derived which always generates an MCT value which is less than or equal to the true value of MCT in the CoM frame. The new technique is demonstrated with case studies of mass measurement with fully leptonic ttbar events and with SUSY events possessing a similar final state.Comment: 33 pages, 33 .eps figures, JHEP3 styl

On the stable degree of graphs

We define the stable degree s(G) of a graph G by s(G)∈=∈ min max d (v), where the minimum is taken over all maximal independent sets U of G. For this new parameter we prove the following. Deciding whether a graph has stable degree at most k is NP-complete for every fixed k∈≥∈3; and the stable degree is hard to approximate. For asteroidal triple-free graphs and graphs of bounded asteroidal number the stable degree can be computed in polynomial time. For graphs in these classes the treewidth is bounded from below and above in terms of the stable degree