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Estimation of brain dynamics under visuomotor task using functional connectivity analysis based on graph theory
Network studies of brain connectivity have demonstrated that the highly connected area, or hub, is a vital feature of human functional and structural brain organization. Hubs identify which region plays an important role in cognitive/sensorimotor tasks. In addition, a complex visuomotor learning skill causes specific changes of neuronal activation across brain regions. Accordingly, this study utilizes the hub as one of the features to map the visuomotor learning tasks and their dynamic functional connectivity (dFC). The electroencephalogram (EEG) data recorded under three different behavior conditions were investigated: motion only (MO), vision only (VO), and tracking (Tra) conditions. Here, we used the phase locking value (PLV) with a sliding window (50 ms) to calculate the dFC at four distinct frequency bands: 8-12 Hz (alpha), 18-22 Hz (low beta), 26-30 Hz (high beta) and 38-42 Hz (gamma), and the eigenvector centrality to evaluate the hub identification. The Gaussian Mixture Model (GMM) was applied to investigate the dFC patterns. The results showed that the dFC patterns with the hub feature represent the characteristic of neuronal activities under visuomotor coordination
Slow dynamics perspectives on the Embodied-Brain Systems Science
AbstractRecent researches point out the importance of the fast-slow cognitive process and learning process of self-body. Bayesian perspectives on the cognitive system also attract research attentions. The view of fast-slow dynamical system has long attracted wide range of attentions from physics to the neurobiology. In many research fields, there is a vast well-organized and coherent behavior in the multi degrees-of-freedom. This behavior matches the mathematical fact that fast-slow system is essentially described with a few variables. In this paper, we review the mathematical basis for understanding the fast-slow dynamical systems. Additionally, we review the basis of Bayesian statistics and provide a fast-slow perspective on the Bayesian inference
Ongoing EEG artifact correction using blind source separation
Objective: Analysis of the electroencephalogram (EEG) for epileptic spike and
seizure detection or brain-computer interfaces can be severely hampered by the
presence of artifacts. The aim of this study is to describe and evaluate a fast
automatic algorithm for ongoing correction of artifacts in continuous EEG
recordings, which can be applied offline and online. Methods: The automatic
algorithm for ongoing correction of artifacts is based on fast blind source
separation. It uses a sliding window technique with overlapping epochs and
features in the spatial, temporal and frequency domain to detect and correct
ocular, cardiac, muscle and powerline artifacts. Results: The approach was
validated in an independent evaluation study on publicly available continuous
EEG data with 2035 marked artifacts. Validation confirmed that 88% of the
artifacts could be removed successfully (ocular: 81%, cardiac: 84%, muscle:
98%, powerline: 100%). It outperformed state-of-the-art algorithms both in
terms of artifact reduction rates and computation time. Conclusions: Fast
ongoing artifact correction successfully removed a good proportion of
artifacts, while preserving most of the EEG signals. Significance: The
presented algorithm may be useful for ongoing correction of artifacts, e.g., in
online systems for epileptic spike and seizure detection or brain-computer
interfaces.Comment: 16 pages, 4 figures, 3 table
A mean field theory of coded CDMA systems
We present a mean field theory of code-division multiple access (CDMA) systems with error-control coding. On the basis of the relation between the free energy and mutual information, we obtain an analytical expression of the maximum spectral efficiency of the coded CDMA system, from which a mean field description of the coded CDMA system is provided in terms of a bank of scalar Gaussian channels whose variances in general vary at different code symbol positions. Regular low-density parity-check (LDPC)-coded CDMA systems are also discussed as an example of the coded CDMA systems
サイトカイン誘発好中球化学誘引物質の発現はTNFα発現を抑制することにより卵胞の閉鎖およびアポトーシスから回避させる
Aim: Cytokine-induced neutrophil chemoattractant (CINC/gro) is a CXC family chemokine, similar to interleukin-8 in rats, and is one of the factors that regulates ovulation. However, the mechanism that regulates atresia of the ovaries postovulation is not clearly defined.
Methods: Whether antibody-blocking of CINC/gro can alter the number of ovulated oocytes and modulate neutrophil infiltration was investigated. The effect of the antibody on the level of inflammatory cytokine production and follicular atresia was examined. Apoptosis was measured by the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) method and via analysis of the messenger RNA expression of Bcl-2 and Bcl2-associated X (Bax).
Results: The anti-CINC/gro antibody treatment decreased the number of ovulated oocytes. The messenger RNA levels of cyclooxygenase-2 and interleukin-1 beta were decreased by the antibody treatment, whereas that of tumor necrosis factor (TNF) alpha was increased. The TUNEL analysis revealed a larger number of apoptotic cells in the antibody group, compared with those in the control group, as well as a significant increase in the Bax/Bcl-2 ratio 24 hours after human chorionic gonadotropin administration.
Conclusion: These findings suggest that ovulation is accelerated by neutrophil infiltration into the theca layer. The CINC/gro appears to synergize with interleukin-1 beta for ovulation. By contrast, the data suggest that CINC/gro expression suppresses TNF alpha expression and that CINC/gro expression therefore prevents the follicles from undergoing atresia and apoptosis
Effect of semen characteristics on pregnancy rate following intrauterine insemination
Objective : To assess the effects of semen characteristics on the success of intrauterine
insemination (IUI). Design : A retrospective study. Settings : The Department
of Obstetrics and Gynecology, Tokushima University Hospital, Japan. Patients : Between
2004 and 2008, 1,177 IUI cycles in 283 couples were studied. Intervention : IUI cycles were
preceded with ovarian stimulation. Main Outcome Measure : Clinical pregnancy. Result :
A total of 82 clinical pregnancies were obtained (7.0% pregnancy rate per cycle, 28.9% per
case). Their subsequent outcomes of pregnancies were 18 miscarriages (21.9%), 2 ectopic
pregnancies (2.4%) and 60 live births (73.2%). Of the 82 clinical pregnancies, 2 were twin
pregnancies (2.4%). There was no triple or higher order multiple pregnancies. At the end
of the sixth cycle, 73 clinical pregnancies had been achieved (89.0%). After diagnostic
laparoscopy, the pregnancy rate per cycle for patients 35 years age was 18%, which is
significantly higher than that of patients 35 years of age. Pregnancies occurred up to
the fifth cycle after laparoscopy. The pregnancy rate (PR) per cycle was significantly
higher in cases of sperm movement rates more than 30% (PR9.3%) and total motile sperm
counts more than 10 106/ml (PR 8.2%). A study comparing the washed and unwashed cases
did not reveal any differences. Conclusion : In male sub-fertility cases of sperm parameters
as motility rates 30% and motile sperm concentration 10 106/ml, IUI could be a
useful option for infertility treatment J. Med. Invest. 5
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