6 research outputs found

    Feasibility of Quantification of Intracranial Aneurysm Pulsation with 4D CTA with Manual and Computer-Aided Post-Processing

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    <div><p>Background and Purpose</p><p>The analysis of the pulsation of unruptured intracranial aneurysms might improve the assessment of their stability and risk of rupture. Pulsations can easily be concealed due to the small movements of the aneurysm wall, making post-processing highly demanding. We hypothesized that the quantification of aneurysm pulsation is technically feasible and can be improved by computer-aided post-processing.</p><p>Materials and Methods</p><p>Images of 14 cerebral aneurysms were acquired with an ECG-triggered 4D CTA. Aneurysms were post-processed manually and computer-aided on a 3D model. Volume curves and random noise-curves were compared with the arterial pulse wave and volume curves were compared between both post-processing modalities.</p><p>Results</p><p>The aneurysm volume curves showed higher similarity with the pulse wave than the random curves (Hausdorff-distances 0.12 vs 0.25, p<0.01). Both post-processing methods did not differ in intra- (r = 0.45 vs r = 0.54, p>0.05) and inter-observer (r = 0.45 vs r = 0.54, p>0.05) reliability. Time needed for segmentation was significantly reduced in the computer-aided group (3.9 ± 1.8 min vs 20.8 ± 7.8 min, p<0.01).</p><p>Conclusion</p><p>Our results show pulsatile changes in a subset of the studied aneurysms with the final prove of underlying volume changes remaining unsettled. Semi-automatic post-processing significantly reduces post-processing time but cannot yet replace manual segmentation.</p></div

    Workflow on the 3D+t model: On axial images the vasculature is defined with a threshold (green).

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    <p>To reduce computation time for the 3D+t model, the volume for post-processing is reduced by placing a VOI over the aneurysm (A). The resulting 3D+t model can be rotated, translated and zoomed (B). Segmentation points are placed on the aneurysms neck (C) and the aneurysm (green) is separated from the parent vessel (red) and the volume and surface is calculated (D).</p

    Results of the intraobserver (mean±LOA -0.02 ± 0.11 vs. 0.01 ± 0.11, upper row) and interobserver agreements (mean±LOA 0.007 ± 0.11 vs. -0.01 ± 0.12 lower row) for the 2D post-processing (right) and 3D+t post-processing (left).

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    <p>Results of the intraobserver (mean±LOA -0.02 ± 0.11 vs. 0.01 ± 0.11, upper row) and interobserver agreements (mean±LOA 0.007 ± 0.11 vs. -0.01 ± 0.12 lower row) for the 2D post-processing (right) and 3D+t post-processing (left).</p
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