The multidimensionality of Japanese kanji abilities

The aim of this study was to identify the cognitive structures of kanji abilities in the Japanese general population and to examine age and cohort effects on them. From a large database of the most popular kanji exam in Japan, we analyzed high school graduation level data of 33, 659 people in 2006 and 16, 971 people in 2016. Confirmatory factor analyses validated the three-dimensional model of kanji abilities, including factors of reading, writing and semantic comprehension. Furthermore, the age effect on writing, and correlations between writing and semantic dimensions, were different between 2006 and 2016, suggesting reduced writing ability and stagnation in integrated mastery of kanji orthography and semantics in current-day Japanese adults. These findings provide the first evidence of the multidimensional nature of Japanese kanji abilities, and age/cohort differences in that dimensional structure. The importance of the habit of handwriting for literacy acquisition is discussed

The unique contribution of handwriting accuracy to literacy skills in Japanese adolescents

漢字の手書きは文章力の発達に独自の貢献をする --読み書き発達の二重経路モデルの提唱--. 京都大学プレスリリース. 2023-04-27.There is widespread concern about declining literacy skills in recent young Japanese. The present study investigated how higher-level reading and writing proficiencies are underpinned by basic literacy skills in Japanese adolescents. From a large database of the most popular literacy exams in Japan, we retrospectively analyzed word- and text-level data for middle and high school students who had taken the exams during the same period in the 2019 academic year using structural equation modeling. We extracted main data for 161 students as well as six independent datasets for validation. Our results validated the three-dimensional view of word-level literacy (reading accuracy, writing accuracy, and semantic comprehension) and demonstrated that writing and semantic skills underpinned text writing and reading, respectively. The semantic comprehension of words affected text writing indirectly via text reading; however, it could not replace the direct effect of word writing accuracy. These findings, which were robustly replicated with multiple independent datasets, provided new evidence of dimension-specific relationships between word- and text-level literacy skills and confirmed the unique contribution of word handwriting acquisition to text literacy proficiency. The replacement of handwriting by digital writing (e.g., typing) is a global trend. However, the dual-pathway model of literacy development identified in this study suggests there are advantages in sustaining early literacy education by handwriting for the growth of higher-level language skills in future generations

Cognitive underpinnings of multidimensional Japanese literacy and its impact on higher-level language skills

漢字の手書き習得が高度な言語能力の発達に影響を与えることを発見 --読み書き習得の生涯軌道に関するフレームワークの提唱--. 京都大学プレスリリース. 2021-01-27.This study aimed to identify the cognitive underpinnings of Japanese kanji abilities and clarify the contributions of kanji acquisition to the development of higher-level language skills based on a three-dimensional view of kanji abilities encompassing reading accuracy, writing accuracy, and semantic comprehension. First, a series of regression analyses was used to identify the multifactorial models of each dimension of Japanese kanji acquisition. These models suggest that, among basic cognitive skills, naming speed, visuospatial processing, and syntactic processing underpin kanji abilities in a dimension-specific manner, whereas phonological processing is a common factor. Second, although all the dimensions of kanji abilities predicted acquired verbal knowledge equally, writing skills on the text level, measured as idea density, were only predicted by the writing dimension (indirectly via acquired knowledge). Our findings represent the first evidence of the dimension-specific relationships of the three dimensions of Japanese kanji abilities with their cognitive predictors, as well as with higher-level language skills. They suggest the importance of handwriting acquisition during school years for the development of language skills through to adulthood. Finally, taking the seminal “Nun study, ” which suggests that higher idea density is protective against dementia, into account, we propose a theoretical framework for the lifelong trajectory of literacy acquisition

Seimei KOOLS-IFU mapping of the gas and dust distributions in Galactic PNe: Unveiling the origin and evolution of Galactic halo PN H4-1

H4-1 is a planetary nebula (PN) located in the Galactic halo, and is notably carbon-rich and one of the most metal-deficient PNe in the Milky Way. To unveil its progenitor evolution through the accurate measurement of the gas mass, we conducted a comprehensive investigation of H4-1, using the newly obtained Seimei/KOOLS-IFU spectra and multiwavelength spectro-photometry data. The emission line images generated from the KOOLS-IFU datacube successfully resolve the ellipsoidal nebula and the equatorial flattened disk that are frequently seen in bipolar PNe evolved from massive progenitors. By a fully data-driven method, we directly derived the seven elemental abundances, the gas-to-dust mass ratio, and the gas and dust masses based on our own distance scale. By comparing the observed quantities with both the photoionization model and the binary nucleosynthesis model, we conclude that the progenitors of an initial mass of 1.87 Msun and 0.82 Msun are second generation stars formed ~4 Gyrs after the Big Bang, and underwent mass-transfers, binary merger, and ultimately evolved into a PN showing unique chemical abundances. Our binary model successfully reproduces the observed abundances and also explains evolutionary time scale of H4-1.Comment: 19 pages, 5 figures, 11 tables, accepted for publication in PAS

The Herschel Planetary Nebula Survey (HerPlaNS) - a comprehensive dusty photoionization model of NGC6781

We perform a comprehensive analysis of the planetary nebula (PN) NGC6781 to investigate the physical conditions of each of its ionized, atomic, and molecular gas and dust components and the object's evolution, based on panchromatic observational data ranging from UV to radio. Empirical nebular elemental abundances, compared with theoretical predictions via nucleosynthesis models of asymptotic giant branch (AGB) stars, indicate that the progenitor is a solar-metallicity, 2.25-3.0 Msun initial-mass star. We derive the best-fit distance of 0.46 kpc by fitting the stellar luminosity (as a function of the distance and effective temperature of the central star) with the adopted post-AGB evolutionary tracks. Our excitation energy diagram analysis indicate high excitation temperatures in the photodissociation region (PDR) beyond the ionized part of the nebula, suggesting extra heating by shock interactions between the slow AGB wind and the fast PN wind. Through iterative fitting using the Cloudy code with empirically-derived constraints, we find the best-fit dusty photoionization model of the object that would inclusively reproduce all of the adopted panchromatic observational data. The estimated total gas mass (0.41 Msun) corresponds to the mass ejected during the last AGB thermal pulse event predicted for a 2.5 Msun initial-mass star. A significant fraction of the total mass (about 70 percent) is found to exist in the PDR, demonstrating the critical importance of the PDR in PNe that are generally recognized as the hallmark of ionized/H+ regions.Comment: 34 pages, 13 Figures and 16 Tables, accepted for publication in the Astrophysical Journal Supplement Serie

Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability

[Introduction]Osteoarthritis (OA) is a common cause of disability in older adults. We have previously reported that an agonist for subtypes EP2 of the prostaglandin E2 receptor (an EP2 agonist) promotes the regeneration of chondral and osteochondral defects. The purpose of the current study is to analyze the effect of this agonist on articular cartilage in a model of traumatic degeneration. [Methods]The model of traumatic degeneration was established through transection of the anterior cruciate ligament and partial resection of the medial meniscus of the rabbits. Rabbits were divided into 5 groups; G-S (sham operation), G-C (no further treatment), G-0, G-80, and G-400 (single intra-articular administration of gelatin hydrogel containing 0, 80, and 400 μg of the specific EP2 agonist, ONO-8815Ly, respectively). Degeneration of the articular cartilage was evaluated at 2 or 12 weeks after the operation. [Results]ONO-8815Ly prevented cartilage degeneration at 2 weeks, which was associated with the inhibition of matrix metalloproteinase-13 (MMP-13) expression. The effect of ONO-8815Ly failed to last, and no effects were observed at 12 weeks after the operation. [Conclusions]Stimulation of prostaglandin E2 (PGE2) via EP2 prevents degeneration of the articular cartilage during the early stages. With a system to deliver it long term, the EP2 agonist could be a new therapeutic tool for OA

A Phenotypic Analysis of Involucrin-Membrane-Bound Ovalbumin Mice after Adoptive Transfer of Ovalbumin-Specific CD8⁺ T Cells

To investigate the mechanism of autoimmunity and peripheral tolerance in the skin, several transgenic mouse strains expressing membrane-bound ovalbumin (mOVA) as an epidermal self-antigen under the control of keratinocyte-specific promotors, such as keratin 5 and keratin 14, were employed in combination with adoptive transfer of CD8⁺ T cells from OT-I mice (OT-I T cells) that recognize an ovalbumin-derived peptide. However, these strains showed bodyweight loss and required additional inflammatory stimuli, such as γ-irradiation and tape-stripping, to induce skin inflammation. In this study, we generated a mouse strain expressing mOVA under the control of human involucrin promoter (involucrin-mOVA mice). In contrast to previous strains, involucrin-mOVA mice spontaneously developed skin inflammation after the transfer of OT-I T cells in the absence of external stimuli without significant bodyweight loss. We focused on the skin infiltration process of OT-I T cells and found that transferred OT-I T cells accumulated around the hair follicles in the early phase of skin inflammation, and in the later phase, the skin inflammation spontaneously resolved despite the remaining OT-I T cells in the skin. Our involucrin-mOVA mice will provide a promising tool to investigate the pathogenesis and the tolerance mechanisms of cytotoxic skin autoimmunity

Trastuzumab タンザイ リョウホウ ガ チョコウ シタ セツジョ フノウ シンコウ イガン ノ 1レイ

Trastuzumab, a humanized monoclonal antibody directed against human epidermal growth factor receptor２ （HER２）, has been shown to be active against metastatic gastric cancer that overexpress HER２. A ７８-year-old man presented with an edema in the lower legs. He was diagnosed as having advanced gastric cancers with multiple liver metastases in our hospital. Immunohistochemistry of the tumor cells revealed HER２ overexpression with an intensity of ３＋. The patient was treated with DS-T chemotherapy （Docetaxel＋S‐１＋Trastuzumab） because of the presence of renal dysfunction. Due to the adverse effect appeared with his skin, DS-T chemotherapy has been canceled and trastuzumab chemotherapy was continued. After １１ months of trastuzumab monotherapy, metastatic liver tumors were diminished. There is very few report of a positive response to trastuzumab in a patient with HER２‐overexpressing metastatic gastric cancer