180 research outputs found
Bioprinting and biomaterials for dental alveolar tissue regeneration
Three dimensional (3D) bioprinting is a powerful tool, that was recently applied to
tissue engineering. This technique allows the precise deposition of cells encapsulated
in supportive bioinks to fabricate complex scaffolds, which are used to repair targeted
tissues. Here, we review the recent developments in the application of 3D bioprinting
to dental tissue engineering. These tissues, including teeth, periodontal ligament,
alveolar bones, and dental pulp, present cell types and mechanical properties with
great heterogeneity, which is challenging to reproduce in vitro. After highlighting the
different bioprinting methods used in regenerative dentistry, we reviewed the great
variety of bioink formulations and their effects on cells, which have been established
to support the development of these tissues. We discussed the different advances
achieved in the fabrication of each dental tissue to provide an overview of the current
state of the methods. We conclude with the remaining challenges and future needsThis work was supported by the Japan Society for the Promotion
of Science (JSPS) KAKENHI (Grant Numbers 22K18936 and
21K04852); AMED (Grant Number JP21gm1310001); The JST
Adaptable and Seamless Technology Transfer Program through
Target-driven R&D (Grant Number JPMJTM22BD), CASIO
SCIENCE PROMOTION FOUNDATION, and by the Research
Center for Biomedical Engineering at Tokyo Medical and Dental
University, Japan
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