Early Rehabilitation with Weight-bearing Standing-shaking-board Exercise in Combination with Electrical Muscle Stimulation after Anterior Cruciate Ligament Reconstruction

The objective of early rehabilitation after anterior cruciate ligament (ACL) reconstruction is to increase the muscle strength of the lower extremities. Closed kinetic chain (CKC) exercise induces co-contraction of the agonist and antagonist muscles. The purpose of this study was to compare the postoperative muscle strength/mass of subjects who performed our new CKC exercise (new rehabilitation group:group N) from week 4, and subjects who received traditional rehabilitation alone (traditional rehabilitation group:group T). The subjects stood on the device and maintained balance. Then, low-frequency stimulation waves were applied to 2 points each in the anterior and posterior region of the injured thigh 3 times a week for 3 months. Measurement of muscle strength was performed 4 times (before the start, and then once a month). Muscle mass was evaluated in CT images of the extensor and flexor muscles of 10 knees (10 subjects) in each group. The injured legs of group N showed significant improvement after one month compared to group T. The cross-sectional area of the extensor muscles of the injured legs tended to a show a greater increase at 3 months in group N. This rehabilitation method makes it possible to contract fast-twitch muscles, which may be a useful for improving extensor muscle strength after ACL reconstruction

Image slicer module for Wide Field Optical Spectrograph (WFOS)

Wide-Field Optical Spectrograph (WFOS) is an optical multi-object spectrograph and one of the first-light instruments of Thirty Meter Telescope (TMT). The WFOS development team has studied three new instrument concepts. One is a fiber-based spectrograph, and other one is a spectrograph using image slicers (Slicer-WFOS). The last one is the simple multi-slit spectrograph. Japanese WFOS team has conducted conceptual studies on Slicer-WFOS in collaboration with California Institute of Technology. Slicer-WFOS has only one VPH grating for each red and blue arm. The gratings offer R~1,500 for a simple 0.″75-width slit. The image slicer divides an object image into three slices and the higher spectral resolution of R~4,500 can be achieved using the same grating. In this proceeding paper, we report our design studies on the slicer module

Image slicer module for Wide Field Optical Spectrograph (WFOS)

Wide-Field Optical Spectrograph (WFOS) is an optical multi-object spectrograph and one of the first-light instruments of Thirty Meter Telescope (TMT). The WFOS development team has studied three new instrument concepts. One is a fiber-based spectrograph, and other one is a spectrograph using image slicers (Slicer-WFOS). The last one is the simple multi-slit spectrograph. Japanese WFOS team has conducted conceptual studies on Slicer-WFOS in collaboration with California Institute of Technology. Slicer-WFOS has only one VPH grating for each red and blue arm. The gratings offer R~1,500 for a simple 0.″75-width slit. The image slicer divides an object image into three slices and the higher spectral resolution of R~4,500 can be achieved using the same grating. In this proceeding paper, we report our design studies on the slicer module

Design study of an image slicer module for a multiobject spectrograph

We investigate an image slicer module for an optical multiobject spectrograph, wide-field optical spectrograph (WFOS), which is one of the first-light instruments of the Thirty Meter Telescope (TMT). The image slicer divides the target image into three slices, thus providing a one-third narrower slit width. By positioning a suite of such modules at the telescope focal surface, multiobject spectroscopy with high spectral resolution can be achieved. Three optical designs are developed: a two-mirror design, a four-mirror design, and a flat-mirror design. Comparing them, the flat-mirror design is found to be the most preferable for WFOS. From a tolerance analysis, the tolerances of manufacturing and assembling appear challenging but not insurmountable. We describe how the steep field curvature of TMT requires at least nine module variants, tuned to reduce defocus in specific focal surface zones. Finally, we introduce a viable mechanical packaging concept

Sclerite formation in the hydrothermal-vent “scaly-foot” gastropod — possible control of iron sulfide biomineralization by the animal

A gastropod from a deep-sea hydrothermal field at the Rodriguez triple junction, Indian Ocean, has scale-shaped structures, called sclerites, mineralized with iron sulfides on its foot. No other organisms are known to produce a skeleton consisting of iron sulfides. To investigate whether iron sulfide mineralization is mediated by the gastropod for the function of the sclerites, we performed a detailed physical and chemical characterization. Nanostructural characterization of the iron sulfide sclerites reveals that the iron sulfide minerals pyrite (FeS2) and greigite (Fe3S4) form with unique crystal habits inside and outside of the organic matrix, respectively. The magnetic properties of the sclerites, which are mostly consistent with those predicted from their nanostructual features, are not optimized for magnetoreception and instead support use of the magnetic minerals as structural elements. The mechanical performance of the sclerites is superior to that of other biominerals used in the vent environment for predation as well as protection from predation. These characteristics, as well as the co-occurrence of brachyuran crabs, support the inference that the mineralization of iron sulfides might be controlled by the gastropod to harden the sclerites for protection from predators. Sulfur and iron isotopic analyses indicate that sulfur and iron in the sclerites originate from hydrothermal fluids rather than from bacterial metabolites, and that iron supply is unlikely to be regulated by the gastropod for iron sulfide mineralization. We propose that the gastropod may control iron sulfide mineralization by modulating the internal concentrations of reduced sulfur compounds

Dental Calculus Stimulates Interleukin-1beta Secretion by Activating NLRP3 Inflammasome in Human and Mouse Phagocytes

Dental calculus is a mineralized deposit associated with periodontitis. The bacterial components contained in dental calculus can be recognized by host immune sensors, such as Toll-like receptors (TLRs), and induce transcription of proinflammatory cytokines, such as IL-1beta. Studies have shown that cellular uptake of crystalline particles may trigger NLRP3 inflammasome activation, leading to the cleavage of the IL-1beta precursor to its mature form. Phagocytosis of dental calculus in the periodontal pocket may therefore lead to the secretion of IL-1beta, promoting inflammatory responses in periodontal tissues. However, the capacity of dental calculus to induce IL-1beta secretion in human phagocytes has not been explored. To study this, we stimulated human polymorphonuclear leukocytes (PMNs) and peripheral blood mononuclear cells (PBMCs) with dental calculus collected from periodontitis patients, and measured IL-1beta secretion by ELISA. We found that calculus induced IL-1beta secretion in both human PMNs and PBMCs. Calculus also induced IL-1beta in macrophages from wild-type mice, but not in macrophages from NLRP3- and ASC-deficient mice, indicating the involvement of NLRP3 and ASC. IL-1beta induction was inhibited by polymyxin B, suggesting that LPS is one of the components of calculus that induces pro-IL-1beta transcription. To analyze the effect of the inorganic structure, we baked calculus at 250 degrees C for 1 h. This baked calculus failed to induce pro-IL-1beta transcription. However, it did induce IL-1beta secretion in lipid A-primed cells, indicating that the crystalline structure of calculus induces inflammasome activation. Furthermore, hydroxyapatite crystals, a component of dental calculus, induced IL-1beta in mouse macrophages, and baked calculus induced IL-1beta in lipid A-primed human PMNs and PBMCs. These results indicate that dental calculus stimulates IL-1beta secretion via NLRP3 inflammasome in human and mouse phagocytes, and that the crystalline structure has a partial role in the activation of NLRP3 inflammasome

Low-temperature Synthesis of FeTe0.5Se0.5 Polycrystals with a High Transport Critical Current Density

We have prepared high-quality polycrystalline FeTe0.5Se0.5 at temperature as low as 550{\deg}C. The transport critical current density evaluated by the current-voltage characteristics is over 700 A/cm2 at 4.2 K under zero field, which is several times larger than FeTe0.5Se0.5 superconducting wires. The critical current density estimated from magneto-optical images of flux penetration is also similar to this value. The upper critical field of the polycrystalline FeTe0.5Se0.5 at T = 0 K estimated by Werthamer-Helfand-Hohenberg theory is 585 kOe, which is comparable to that of single crystals. This study gives some insight into how to improve the performance of FeTe0.5Se0.5 superconducting wires.Comment: 12 pages, 6 figure

Reduced risk of recurrent myocardial infarction in homozygous carriers of the chromosome 9p21 rs1333049 c risk allele in the contemporary percutaneous coronary intervention era: A prospective observational study

Hara M, Sakata Y, Nakatani D on behalf of the OACIS Investigators, et al. Reduced risk of recurrent myocardial infarction in homozygous carriers of the chromosome 9p21 rs1333049 C risk allele in the contemporary percutaneous coronary intervention era: a prospective observational study. BMJ Open 2014;4:e005438. doi: 10.1136/bmjopen-2014-00543

Design study of an image slicer module for a multiobject spectrograph

We investigate an image slicer module for an optical multiobject spectrograph, wide-field optical spectrograph (WFOS), which is one of the first-light instruments of the Thirty Meter Telescope (TMT). The image slicer divides the target image into three slices, thus providing a one-third narrower slit width. By positioning a suite of such modules at the telescope focal surface, multiobject spectroscopy with high spectral resolution can be achieved. Three optical designs are developed: a two-mirror design, a four-mirror design, and a flat-mirror design. Comparing them, the flat-mirror design is found to be the most preferable for WFOS. From a tolerance analysis, the tolerances of manufacturing and assembling appear challenging but not insurmountable. We describe how the steep field curvature of TMT requires at least nine module variants, tuned to reduce defocus in specific focal surface zones. Finally, we introduce a viable mechanical packaging concept