Future ground arrays for ultrahigh-energy cosmic rays: recent updates and perspectives

The origin and nature of ultrahigh-energy cosmic rays (UHECRs) are one of the most intriguing mysteries in particle astrophysics and astronomy. The two largest observatories, the Pierre Auger Observatory and the Telescope Array Experiment, are steadily observing UHECRs in both hemispheres in order to better understand their origin and associated acceleration mechanisms at the highest energies. We highlight their latest results including on-going upgrades, AugerPrime and TAx4, and then address the requirements for a next-generation observatory. We share recent updates and perspectives for a future ground array of fluorescence detectors, addressing the requirements for a large-area, low-cost detector suitable for measuring the properties of the highest energy cosmic rays with an unprecedented aperture.Comment: Invited talk in ISVHECRI 2018, Nagoya, Japa

The Mass Composition of Ultra-high Energy Cosmic Rays Measured by New Fluorescence Detectors in the Telescope Array Experiment

AbstractThe longitudinal development of an extensive air shower reaches its maximum at a depth, Xmax, that depends on the species of the primary cosmic ray. Using a technique based on Xmax, we measure the cosmic-ray mass composition from analyses of 3.7 years of monocular mode operations with the newly constructed fluorescence detectors of the Telescope Array experiment. The Xmax analysis shows our data to be consistent with a proton dominant composition at energies above 1018.0eV

INHIBITION OF TUBULIN-DEPENDENT ADENOSINE TRIPHOSPHATASE (ATPASE) ACTIVITY IN MICROTUBULE PROTEINS FROM PORCINE BRAIN BY COLCHICINE

ArticleJournal of the Faculty of Textile Science and Technology, Shinshu University. Ser. A, Biology 25: 1-7(1986)departmental bulletin pape

Early Rehabilitation with Weight-bearing Standing-shaking-board Exercise in Combination with Electrical Muscle Stimulation after Anterior Cruciate Ligament Reconstruction

The objective of early rehabilitation after anterior cruciate ligament (ACL) reconstruction is to increase the muscle strength of the lower extremities. Closed kinetic chain (CKC) exercise induces co-contraction of the agonist and antagonist muscles. The purpose of this study was to compare the postoperative muscle strength/mass of subjects who performed our new CKC exercise (new rehabilitation group:group N) from week 4, and subjects who received traditional rehabilitation alone (traditional rehabilitation group:group T). The subjects stood on the device and maintained balance. Then, low-frequency stimulation waves were applied to 2 points each in the anterior and posterior region of the injured thigh 3 times a week for 3 months. Measurement of muscle strength was performed 4 times (before the start, and then once a month). Muscle mass was evaluated in CT images of the extensor and flexor muscles of 10 knees (10 subjects) in each group. The injured legs of group N showed significant improvement after one month compared to group T. The cross-sectional area of the extensor muscles of the injured legs tended to a show a greater increase at 3 months in group N. This rehabilitation method makes it possible to contract fast-twitch muscles, which may be a useful for improving extensor muscle strength after ACL reconstruction

Revisiting ultrahigh-energy constraints on decaying super-heavy dark matter

We revisit constraints on decaying very heavy dark matter (VHDM) using the latest ultrahigh-energy cosmic-ray (UHECR; $E\gtrsim 10^{18}$ eV) data and ultrahigh-energy (UHE) $\gamma$-ray flux upper limits, measured by the Pierre Auger Observatory. We present updated limits on the VHDM lifetime ($\tau_\chi$) for masses up to $\sim10^{15}$~GeV, considering decay into quarks, leptons, and massive bosons. In particular, we consider not only the UHECR spectrum but their composition data that favors heavier nuclei. Such a combined analysis improves the limits at $\lesssim 10^{12}$~GeV because VHDM decay does not produce UHECR nuclei. We also show that the constraints from the UHE $\gamma$-ray upper limits are $\sim10$ more stringent for all of the Standard Model final states we consider.Comment: 9 pages, 5 figure

Chemistry of Cu deposition by Cu(hfac)(tmvs) monitored by Li⁺ ion attachment mass spectrometry

Ion attachment mass spectrometry was used for continuous in situanalysis of coordinated products formed during copperchemical vapor deposition(CuCVD) by Cu(1,1,1,5,5,5-hexafluoroacetylacetonate)(vinyltrimethylsilane) [Cu(hfac)(tmvs)] in a simple tubular reactor. This study of the thermally labile Cu(hfac)(tmvs) demonstrated the utility of this method for detecting molecular ions of labile compounds. The results demonstrate the feasibility of monitoring the deposition chemistry of Cu(hfac)(tmvs) by generating Li⁺ adduct molecular ions by means of the Li⁺ ion attachment technique. The reaction pathways for CuCVD by Cu(hfac)(tmvs) were studied by analysis of the reaction products. H(hfac) and tmvs were identified as the main products when Cu(hfac)tmvs was heated at temperatures ranging from room temperature to 160°C in the reactor. The rate constant for Cu deposition, k (1/s), was determined to be 1.6×10⁶exp(−10.2kcal/molRt).This work was supported in part by The New Energy and Industrial Technology Development Organization NEDO under a fund for Fundamental Technology Research Facilitation Program

Evaluation and design of function for tracing diffusion of classified information for file operations with KVM

Cases of classified information leakage have become increasingly common. To address this problem, we have developed a function for tracing the diffusion of classified information within an operating system. However, this function suffers from the following two problems: first, in order to introduce the function, the operating system's source code must be modified. Second, there is a risk that the function will be disabled when the operating system is attacked. Thus, we have designed a function for tracing the diffusion of classified information in a guest operating system by using a virtual machine monitor. By using a virtual machine monitor, we can introduce the proposed function in various environments without modifying the operating system's source code. In addition, attacks aimed at the proposed function are made more difficult, because the virtual machine monitor is isolated from the operating system. In this paper, we describe the implementation of the proposed function for file operations and child process creation in the guest operating system with a kernel-based virtual machine. Further, we demonstrate the traceability of diffusing classified information by file operations and child process creation. We also report the logical lines of code required to introduce the proposed function and performance overheads

Unveiling the roles of the glutathione redox system in vivo by analyzing genetically modified mice

Redox status affects various cellular activities, such as proliferation, differentiation, and death. Recent studies suggest pivotal roles of reactive oxygen species not only in pathogenesis under oxidative insult but also in intracellular signal transduction. Glutathione is present in several millimolar concentrations in the cytoplasm and has multiple roles in the regulation of cellular homeostasis. Two enzymes, γ-glutamylcysteine synthetase and glutathione synthetase, constitute the de novo synthesis machinery, while glutathione reductase is involved in the recycling of oxidized glutathione. Multidrug resistant proteins and some other transporters are responsible for exporting oxidized glutathione, glutathione conjugates, and S-nitrosoglutathione. In addition to antioxidation, glutathione is more positively involved in cellular activity via its sulfhydryl moiety of a molecule. Animals in which genes responsible for glutathione metabolism are genetically modified can be used as beneficial and reliable models to elucidate roles of glutathione in vivo. This review article overviews recent progress in works related to genetically modified rodents and advances in the elucidation of glutathione-mediated reactions