6 research outputs found
BEHAVIOR OF BIOMARKERS LINKING INFLAMMATION AND THROMBOSIS IN THE INFARCT-RELATED CORONARY ARTERY AND SYSTEMIC CIRCULATION AFTER PRIMARY PERCUTANEOUS CORONARY INTERVENTION FOR THE TREATMENT OF ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION
IMPACT OF PIOGLITAZONE ON CORONARY ATHEROSCLEROSIS IN PATIENTS WITH NON- AND EARLY-DIABETES: A PROSPECTIVE RANDOMIZED STUDY WITH INTRAVASCULAR ULTRASOUND
Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2
Semaphorins, originally identified as axon guidance factors in the nervous system, play integral roles in organogenesis. Here, we demonstrate a critical involvement of Sema6D in cardiac morphogenesis. Ectopic expression of Sema6D or RNA interference against Sema6D induces expansion or narrowing of the ventricular chamber, respectively, during chick embryonic development. Sema6D also exerts region-specific activities on cardiac explants, a migration-promoting activity on outgrowing cells from the conotruncal segment, and a migration-inhibitory activity on those from the ventricle. Plexin-A1 mediates these activities as the major Sema6D-binding receptor. Plexin-A1 forms a receptor complex with vascular endothelial growth factor receptor type 2 in the conotruncal segment or with Off-track in the ventricle segment; these complexes are responsible for the effects of Sema6D on the respective regions. Thus, the differential association of Plexin-A1 with additional receptor components entitles Sema6D to exert distinct biological activities at adjacent regions. This is crucial for complex cardiac morphogenesis