A Case of Hypocalcaemia Due to Vitamin D Deficiency in ‘Hikikomori’ Syndrome

Objective: To describe hypocalcaemia due to vitamin D deficiency in ‘hikikomori’ syndrome. Materials and methods: A 37-year-old man with ‘hikikomori’ syndrome for a year was admitted with hypocalcaemia (serum ionic calcium 1.17 mmol/l). Serum 1,25(OH)2-vitamin D3 determined by liquid chromatography–tandem mass spectrometry was depressed at 12.1 pg/ml (29.0 pmol/l) and plasma intact PTH elevated at 324 ng/l. Administration of 1 μg/day 1α(OH)-vitamin D3 and 1 g/day calcium lactate for 1 week normalized calcium and PTH, and raised 1,25(OH)2-vitamin D3 to low normal levels. Conclusion: This is the first report of hypocalcaemia due to vitamin D deficiency in a patient with ‘hikikomori’ syndrome

Probing Intergalactic Neutral Hydrogen by the Lyman Alpha Red Damping Wing of Gamma-Ray Burst 130606A Afterglow Spectrum at z = 5.913

The unprecedentedly bright optical afterglow of GRB 130606A located by Swift at a redshift close to the reionization era (z = 5.913) provides a new opportunity to probe the ionization status of intergalactic medium (IGM). Here we present an analysis of the red Ly alpha damping wing of the afterglow spectrum taken by Subaru/FOCAS during 10.4-13.2 hr after the burst. We find that the minimal model including only the baseline power-law and HI absorption in the host galaxy does not give a good fit, leaving residuals showing concave curvature in 8400-8900 A with an amplitude of about 0.6% of the flux. Such a curvature in the short wavelength range cannot be explained either by extinction at the host with standard extinction curves, intrinsic curvature of afterglow spectra, or by the known systematic uncertainties in the observed spectrum. The red damping wing by intervening HI gas outside the host can reduce the residual by about 3 sigma statistical significance. We find that a damped Ly alpha system is not favored as the origin of this intervening HI absorption, from the observed Ly beta and metal absorption features. Therefore absorption by diffuse IGM remains as a plausible explanation. A fit by a simple uniform IGM model requires HI neutral fraction of f_HI ~ 0.1-0.5 depending on the distance to the GRB host, implying high f_HI IGM associated with the observed dark Gunn-Peterson (GP) troughs. This gives a new evidence that the reionization is not yet complete at z ~ 6.Comment: 11 pages, 6 figures, accepted to PASJ after minor revision

Study of Negative-Ion TPC Using {\mu}-PIC for Directional Dark Matter Search

Negative-ion time projection chambers(TPCs) have been studied for low-rate and high-resolution applications such as dark matter search experiments. Recently, a full volume fiducialization in a self-triggering TPC was realized. This innovative technology demonstrated a significant reduction in the background with MWPC-TPCs. We studied negative-ion TPC using the {\mu}-PIC+GEM system and obtained sufficient gas gain with CS$_{2}$gas and SF$_{6}$ gas at low pressures. We expect an improvement in detector sensitivity and angular resolution with better electronics

Current status and future plan of the Program of the Antarctic Syowa MST/IS radar (PANSY)

The Tenth Symposium on Polar Science/Special session: [S] Future plan of Antarctic research: Towards phase X of the Japanese Antarctic Research Project (2022-2028) and beyond, Tue. 3 Dec. / 2F Auditorium, National Institute of Polar Researc

Reactivity of CA19-9 and CA125 in Histological Subtypes of Epithelial Ovarian Tumors and Ovarian Endometriosis

Previous reports have shown that some ovarian endometrioid adenocarcinomas and ovarian clear cell adenocarcinomas derive from ovarian endometriosis (OE), and that endocervical-like mucinous borderline ovarian tumors are associated with OE. We examined the relationship between the staging and histological subtypes of OE or epithelial ovarian tumors (EOT) and the serum levels of carbohydrate antigen 19-9 (CA19-9) and carbohydrate antigen 125 (CA125) to evaluate the potential of these markers for preoperative diagnosis. First, we analyzed the preoperative serum levels of CA19-9 and CA125 in 195 patients who were histopathologically diagnosed with OE or EOT. We then performed a case-control study in which 308 women were enrolled, the 195 women described above and 113 healthy women as control subjects. Serum CA19-9 and CA125 levels were found to be useful in differentiating between OE and serous adenocarcinoma, but not between OE and other EOT. Moreover, serum CA19-9 levels were useful for preoperative assessment between OE and stage I mucinous borderline ovarian tumors, with or without the interstitial infiltration. In addition, considering that the serum CA19-9 levels in stage I mucinous borderline ovarian tumors were elevated via the interstitial infiltration of leukocytes and that precancerous lesions are associated with a cancerous glycosylation disorder in the process of inflammatory carcinogenesis, the CA19-9 level may be considered a suitable biomarker for estimating drug susceptibility

Development of cosmic x-ray polarimeter

We present a performance study of a cosmic X-ray polarimeter which is based on the photoelectric effect in gas, and sensitive to a few to 30 keV range. In our polarimeter, the key device would be the 50 μm pitch Gas Electron Multiplier (GEM). We have evaluated the modulation factor using highly polarized X-ray, provided by a synchrotron accelerator. In the analysis, we selected events by the eccentricity of the charge cloud of the photoelectron track. As a result, we obtained the relationship between the selection criteria for the eccentricity and the modulation factors; for example, when we selected the events which have their eccentricity of > 0.95, the polarimeter exhibited with the modulation factor of 0.32. In addition, we estimated the Minimum Detectable Polarization degree (MDP) of Crab Nebula with our polarimeter and found 10 ksec observation is enough to detect the polarization, if we adopt suitable X-ray mirrors

Fine-pitch and thick-foil gas electron multipliers for cosmic x-ray polarimeters

We have produced various gas electron multiplier foils (GEMs) by using laser etching technique for cosmic X-ray polarimeters. The finest structure GEM we have fabricated has 30 μm-diameter holes on a 50 μm-pitch. The effective gain of the GEM reaches around 5000 at the voltage of 570 V between electrodes. The gain is slightly higher than that of the CERN standard GEM with 70 μm-diameter holes on a 140 μm-pitch. We have fabricated GEMs with thickness of 100 μm which has two times thicker than the standard GEM. The effective gain of the thick-foil GEM is 104 at the applied voltage of 350 V per 50 μm of thickness. The gain is about two orders higher than that of the standard GEM. The remarkable characteristic of the thick-foil GEM is that the effective gain at the beginning of micro-discharge is quite improved. For fabricating the thick-foil GEMs, we have employed new material, liquid crystal polymer (LCP) which has little moisture absorption rate, as an insulator layer instead of polyimide. One of the thick-foil GEM we have fabricated has 8 μm copper layer in the middle of the 100 μm-thick insulator layer. The metal layer in the middle of the foil works as a field-shaper in the multiplication channels, though it slightly decreases the effective gain