Legislative Documents

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Additional file 2: of An integrated -omics analysis of the epigenetic landscape of gene expression in human blood cells

eCpG-transcript pairs, plus additional information for MESA. (TXT 44022 kb

Additional file 3: of An integrated -omics analysis of the epigenetic landscape of gene expression in human blood cells

UCSC track for eCpGs from GTP. (BED 2584 kb

Additional file 4: of An integrated -omics analysis of the epigenetic landscape of gene expression in human blood cells

UCSC track for eCpGs from MESA. (BED 8181 kb

<i>Fkbp5</i> DNA methylation decreases with age in mice.

<p>Isolated DNA samples from wild-type mice aged 1 (n = 3), 3.5 (n = 3), 4 (n = 6), 5 (n = 7), 6 (n = 6), and 12 (n = 3) months were subjected to bisulfite pyrosequencing. Multiple CpG sites in intron 5 were analyzed for <i>Fkbp5</i> methylation. Significant demethylation was found at CPG_3 (r = −0.3890, p<0.05), CPG_4 (r = −0.4004, p<0.05) and CpG_5 (r = −0.5044, p<0.01) as measured by linear regression analyses.</p

Blood composition and animal mass of wild-type versus FKBP5^−/− mice do not differ.

<p>WBC: white blood cells, RBC: red blood cells, Lym: lymphocytes, Mono: monocytes, Gran: granulocytes, HGB: hemoglobin, PLT: platelets. Wild-type, n = 11; FKBP5^−/−, n = 12. Values are listed as the mean ± the standard error of the mean.</p><p>Blood composition and animal mass of wild-type versus FKBP5^−/− mice do not differ.</p

FKBP51 does not affect longevity.

<p>No significant differences were found in the percent survival of wild-type (wt) and <i>FKBP5^−/−</i> mice, p>0.05. wt, n = 34 (18 male and 16 female); <i>FKBP5^−/−</i>, n = 32 (18 male and 14 female).</p

<i>FKBP5^−/−</i> mice display enhanced cognitive flexibility in the radial arm water maze.

<p>(A) No differences were found in acquisition learning between genotypes (p>0.05). (B) There was a main effect of genotype (p<0.05) during reversal training, indicating <i>FKBP5^−/−</i> mice made fewer errors across sessions. Data points represent a session of three trials. *p<0.05. wild-type (wt), n = 9; <i>FKBP5^−/−</i>, n = 10.</p

Deletion of <i>FKBP5</i> does not alter glucose metabolism.

<p><i>FKBP5^−/−</i> mice displayed normal glucose tolerance up to 120 minutes following glucose injection compared to wild-type (wt) mice, p>0.05. wt, n = 7; <i>FKBP5^−/−</i>, n = 10.</p

Ablation of <i>FKBP5</i> does not alter cytokine levels over time.

<p>Serum levels of interleukin-1β (A) and interleukin-5 (D) were decreased at 6 months (p<0.05 via t-test) but not across time (p>0.05 by two-way ANOVA). Levels of interleukin-2 (B), interleukin-4 (C), interleukin-10 (E), granulocyte-macrophage colony-stimulating factor (F), interferon gamma (G), or tumor necrosis factor alpha (H) did not differ between genotypes across lifespan, p>0.05. *p<0.05. wild-type (wt), n = 6 for each age; <i>FKBP5^−/−</i>, n = 7 at 7 and 10 months, n = 6 at 21 months.</p