El CEIP Pare Ignasi Puig, una escola en els marges : Característiques d'aquest CEIP i del barri d'El Xup

El present treball presenta una descripció etnogràfica del barri d'El Xup (Manresa), on es presenta el barri i es parla especialment de la seva escola pública. També s'exposen les estratègies adoptades per la Generalitat de Catalunya per fer front, en les escoles catalanes, al notable increment d'alumnat immigrat a les aules.El presente trabajo presenta una descripción etnográfica del barrio de El Xup (Manresa), donde se presenta el barrio y se habla especialmente de su escuela pública. También se exponen las estrategias adoptadas por la Generalitat de Catalunya para hacer frente, en las escuelas catalanas, al notable incremento de alumnado inmigrante en las aulas.Bachelor thesis for the Humanities program

New Biomarkers in Acute Tubulointerstitial Nephritis: A Novel Approach to a Classic Condition

Acute tubulointerstitial nephritis (ATIN) is an immunomediated cause of acute kidney injury. The prevalence of ATIN among the causes of acute kidney injury (AKI) is not negligible, especially those cases related to certain drugs. To date, there is a lack of reliable non-invasive diagnostic and follow-up markers. The gold standard for diagnosis is kidney biopsy, which shows a pattern of tubulointerstitial leukocyte infiltrate. The urinalysis findings can aid in the diagnosis but are no longer considered sensitive or specific. Atthe present time, there is a rising attentiveness tofinding trustworthy biomarkers of the disease, with special focus in urinary cytokines and chemokines that may reflect kidney local inflammation. Cell-based tests are of notable interest to identify the exact drug involved in hypersensitivity reactions to drugs, manifesting as ATIN. Certain single-nucleotide polymorphisms in HLA or cytokine genes may confer susceptibility to the disease according to pathophysiological basis. In this review, we aim to critically examine and summarize the available evidence on this topic

Alkaloid profile in Pyrolirion albicans Herb. (Amaryllidaceae), a Peruvian endemic species

The Amaryllidaceae family is widely distributed in different regions of the neotropics and temperate areas of the world. Species of the subfamily Amaryllidoideae are unique in producing the alkaloid galanthamine, which inhibits the action of acetylcholinesterase and is used for the treatment of Alzheimer's disease. In Perú, 15 genera and 68 species belonging to the Amaryllidoideae have been reported in different types of forest, ranging from wet montane to dry, as well as the sandy biomes of the Pacific coastal region, with the greatest diversity in the south. In the tribe Eustephieae, the Andean genus Pyrolirion Herb has eight species, six of which are endemic to Peru. In this work, the leaves and bulbs of Pyrolirion albicans were analyzed for their alkaloid content for the first time, using gas chromatography (GC) coupled to mass spectrometry (MS). The alkaloids determined in the leaves were galanthamine, chlidanthine, tazettine and lycorine and those in the bulbs were galanthamine, N-demethylgalanthamine, vittatine/crinine, montanine, pancracine, sternbergine, lycorine and hippeastrine. Owing to their important bioactive properties, the high quantity of montanine and galanthamine determined in the bulbs is of particular interest. Keywords Amaryllidaceae alkaloids, GC-MS, Galanthamine, Montanine, Pyrolirion albicans, Endemis

QToF exact mass and ESI fragmentation of bioactive Amaryllidaceae alkaloids

Amaryllidaceae alkaloids are a particular group of alkaloids exclusive to the Amarylloideae subfamily. Important from a biological and pharmacological point of view, they have antiparasitic, antiviral and antitumoral activities. Notably, galanthamine has been approved by the FDA as an acetylcholinesterase inhibitory drug for the treatment of Alzheimer's disease. Overall, Amaryllidaceae alkaloids are easy to analyse by GC–MS, but some are difficult to differentiate or detect. In the current study, some of these problems were resolved by applying an alternative analytical technique, high resolution ESI-MS/MS, a soft ionisation method producing different fragmentation patterns. Amongst the Amaryllidaceae alkaloids, only galanthamine has been previously analysed by high resolution ESI-MS/MS. In this work, a large number of Amaryllidaceae alkaloids were studied by high resolution ESI-MS/MS, providing important new structural information

Research in natural products: Amaryllidaceae ornamental plants as sources of bioactive compounds

Podeu consultar el llibre complet a: http://hdl.handle.net/2445/12071

Challenging Bourdieu's Theory: Dialogic Interaction as a Means to Provide Access to Highbrow Culture for All

According to Bourdieu, class position is related to cultural capital, taste, and preferences. Accordingly, the author states that, because of their 'habitus,' those from high social classes have higher cultural capital and preferences for highbrow culture, which gives them more chances to succeed in life. On the contrary, those from low social classes have lower cultural capital because of their lowbrow cultural preferences, which makes it more difficult for them to achieve in a system that favors the dominant classes. Through the review of articles on Dialogic Literary Gatherings published in peer-reviewed journals, this article aims to provide more insights on how the principles of dialogic learning occur. The results of the review challenge Bourdieu's concept of 'habitus,' providing evidence of how socioeconomic status (SES) is not determinant to cultural capital

Changes in tongue kissing in hook-ups after COVID-19

A growing body of social and behavioral sciences studies are providing evidence on how COVID-19 is influencing changes in society and among individuals. A few of those studies focus on how it is affecting behavioral and habit changes in stable couples. Yet its influence on changes in hook-ups remains understudied. To contribute to filling this gap, this exploratory study analyzes changes related to tongue kissing in hook-ups promoted by increased awareness of tongue kissing certain people as a potential source of transmission. Through pre- and post-test questionnaires given to 20 girls (18-30 years old), potential changes in the memories of past tongue-kissing hook-ups and in intentions and perceptions towards future ones can be observed among 12 participants. The implications of these findings suggest not only how the new normal might affect tongue kissing in hook-ups among these girls but also how these girls might freely decide with whom to engage in sexual-affective relationships in the future

T-lymphocyte in ANCA-associated vasculitis: what do we know? A pathophysiological and therapeutic approach

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is an autoimmune condition that commonly causes kidney impairment and can be fatal. The key participation of B-lymphocytes as ANCA producers and neutrophils as target of these antibodies is widely described as the mechanism of endothelial damage in this disease. There has been a rising interest in the role of T-lymphocytes in AAV in recent years. Evidence is strong from animal models, and T-lymphocytes can be found infiltrating kidney tissue and other tissue sites in AAV patients. Furthermore, the different subsets of T-lymphocytes are also key players in the aberrant immune response observed in AAV. Polarization towards a predominant Th1 and Th17 response in the acute phase of the disease has been described, along with a decline in the number of T-regulatory lymphocytes, which, in turn, show functional impairment. Interactions between different T-cell subsets, and between T-cells and neutrophils and B-cells, also enhance the inflammatory response, constituting a complex network. Novel therapies targeting T-cell immunity are emerging in this scenario and may constitute an interesting alternative to conventional therapy in selected patients. This review aims to summarize the available evidence regarding T-cell imbalances and functional impairment, especially focusing on renal involvement of AAV

The physicochemical, biopharmaceutical, and in vitro efficacy properties of freeze-dried dexamethasone-loaded lipomers.

Dexamethasone-loaded polymer hybrid nanoparticles were developed as a potential tool to treat alopecia areata due to their follicular targeting ability. Freeze drying (FD) is a common technique used to improve nanoparticle stability; however, there are few studies focused on its effect on ethyl cellulose lipid-core nanoparticles. Nanoparticles were lyophilized with different cryoprotectants. Sucrose was selected because it allowed for a good resuspension and provided acceptable physicochemical parameters (374.33 nm, +34.7 mV, polydispersion 0.229%, and 98.87% encapsulation efficiency). The nanoparticles obtained were loaded into a pleasant xanthan gum hydrogel, and the rheological, release, and skin permeation profiles of different formulations were studied. The FD formulation significantly modified the particle size, and the drug release and permeation properties were also altered. In addition, analyses of the cytotoxicity and anti-inflammatory efficacy of FD and non-FD particles on human keratinocytes indicated no differences

Datasets for the validation of the "in vivo" siRNA-silencing of CD40 and for the detection of new markers of atherosclerosis progression in ApoE-deficient mice

AbstractData presented in this Data in Brief article correspond to the article "in vivo" silencing of CD40 reduces progression of experimental atherogenesis through a NFκB/miR-125b axis and reveals new potential mediators in the pathogenesis of atherosclerosis" (M. Hueso, L. De Ramon, E. Navarro, E. Ripoll, J.M. Cruzado, J.M. Grinyo, J. Torras, 2016) [1]. Here, we describe the validation of the silencing of CD40 expression with a specific siRNA in ApoE−/− mouse aortas, and its systemic effects on splenic lymphocytic subpopulations as well as on the infiltration of aortic intima by F4/80+, galectin-3+ macrophages or by NF-κB+ cells. We also show the output of a Gene Ontology and TLDA analysis which allowed the detection of potential mediators of atherosclerosis progression. We provide the scientific community with a set of genes whose expression is increased during atherosclerosis progression but downregulated upon CD40 silencing