329 research outputs found
Bridging The Coaching/Therapy Divide: What Co-Active Coaches Can Learn From ACT (Acceptance And Commitment Therapy)
Abstract This paper situates the coaching/therapy divide within the context of new regulations in Ontario, Canada, that limit the use of the term 'psychotherapy,' and the practice of psychotherapy. Taking Co-Active Coaching and Acceptance and Commitment Therapy (ACT) as representative examples of coaching and therapy respectively, I examine each in turn, showing that Co-Active Coaching and ACT, as they are described by their founders, overlap in important ways, to the point they are almost indistinguishable in practice. I conclude that artificially distinguishing between coaching and therapy is unhelpful for therapists and coaches, as well as the client populations they serve
A new experimental snow avalanche test site at Seehore peak in Aosta Valley (NW Italian Alps) - Part II: Engineering aspects
The estimate of the effects produced by the impact of a snow avalanche against an obstacle is of the utmost importance in designing safe mountain constructions. For this purpose, an ad-hoc instrumented obstacle was designed and built in order to measure impact forces of small and medium snow avalanches at Seehore peak (NW Italian Alps). The structural design had to consider several specific and unusual demands dictated by the difficult environment. In this article, the new test facility is described from the engineering point of view, discussing the most important aspects of the analyzed problems which were solved before and after the construction. The performance of the instrumented obstacle in the first two operating seasons, and some proposals for future upgrading are eventually illustrate
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Toxin studies using an integrated biophysical and structural biology approach.
Clostridial neurotoxins, such as botulinum and tetanus, are generally thought to invade neural cells through a process of high affinity binding mediated by gangliosides, internalization via endosome formation, and subsequent membrane penetration of the catalytic domain activated by a pH drop in the endosome. This surface recognition and internalization process is still not well understood with regard to what specific membrane features the toxins target, the intermolecular interactions between bound toxins, and the molecular conformational changes that occur as a result of pH lowering. In an effort to elucidate the mechanism of tetanus toxin binding and permeation through the membrane a simple yet representative model was developed that consisted of the ganglioside G{sub tlb} incorporated in a bilayer of cholesterol and DPPC (dipalmitoylphosphatidyl choline). The bilayers were stable over time yet sensitive towards the binding and activity of whole toxin. A liposome leakage study at constant pH as well as with a pH gradient, to mimic the processes of the endosome, was used to elucidate the effect of pH on the toxin's membrane binding and permeation capability. Topographic imaging of the membrane surface, via in situ tapping mode AFM, provided nanoscale characterization of the toxin's binding location and pore formation activity
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