40 research outputs found
A "hair-raising" history of alopecia areata
Get PDFYesA 3500âyearâold papyrus from ancient Egypt provides a list of treatments for many diseases including âbite hair loss,â most likely alopecia areata (AA). The treatment of AA remained largely unchanged for over 1500 years. In 30 CE, Celsus described AA presenting as scalp alopecia in spots or the âwindings of a snakeâ and suggested treatment with caustic compounds and scarification. The first âmodernâ description of AA came in 1813, though treatment still largely employed caustic agents. From the midâ19th century onwards, various hypotheses of AA development were put forward including infectious microbes (1843), nerve defects (1858), physical trauma and psychological stress (1881), focal inflammation (1891), diseased teeth (1902), toxins (1912) and endocrine disorders (1913). The 1950s brought new treatment developments with the first use of corticosteroid compounds (1952), and the first suggestion that AA was an autoimmune disease (1958). Research progressively shifted towards identifying hair follicleâspecific autoantibodies (1995). The potential role of lymphocytes in AA was made implicit with immunohistological studies (1980s). However, studies confirming their functional role were not published until the development of rodent models (1990s). Genetic studies, particularly genomeâwide association studies, have now come to the forefront and open up a new era of AA investigation (2000s). Today, AA research is actively focused on genetics, the microbiome, dietary modulators, the role of atopy, immune cell types in AA pathogenesis, primary antigenic targets, mechanisms by which immune cells influence hair growth, and of course the development of new treatments based on these discoveries.Alopecia UK
The History of Four-footed Beasts
No full textThe LEME Corpus Manual has an editorial introduction, indexes of subjects, proper names, and chronology, a primary bibliography of LEME corpus texts, as well as English language texts not included in the Corpus, a description of the XML encoding and of lemmatization and source analysis tools. The appendix includes lists of language abbreviations and of abbreviations for parts of speech.Social Sciences and Humanities Research Council of CanadaCanada Foundation for InnovationUniversity of Toronto LibrariesUniversity of Toronto PressInformation & Instructional Technology, Faculty of Arts and Science, University of Toront
Of Serpents
No full textThe LEME Corpus Manual has an editorial introduction, indexes of subjects, proper names, and chronology, a primary bibliography of LEME corpus texts, as well as English language texts not included in the Corpus, a description of the XML encoding and of lemmatization and source analysis tools. The appendix includes lists of language abbreviations and of abbreviations for parts of speech.Social Sciences and Humanities Research Council of CanadaCanada Foundation for InnovationUniversity of Toronto LibrariesUniversity of Toronto PressInformation & Instructional Technology, Faculty of Arts and Science, University of Toront
The revvard of religion Deliuered in sundrie lectures vpon the booke of Ruth, wherein the godly may see their daily and outwarde tryals, with the presence of God to assist them, and his mercies to recompence them: verie profitable for this present time of dearth, wherein manye are most pittifully tormented with want; and also worthie to bee considered in this golden age of the preaching of the word, when some vomit vp the loathsomnes therof, and others fall away to damnable securitie.
No full textThe historie of foure-footed beastes Describing the true and liuely figure of euery beast, with a discourse of their seuerall names, conditions, kindes, vertues (both naturall and medicinall) countries of their breed, their loue and hate to mankinde, and the wonderfull worke of God in their creation, preseruation, and destruction. Necessary for all diuines and students, because the story of euery beast is amplified with narrations out of Scriptures, fathers, phylosophers, physitians, and poets: wherein are declared diuers hyerogliphicks, emblems, epigrams, and other good histories, collected out of all the volumes of Conradus Gesner, and all other writers to this present day. By Edward Topsell.
No full textThe house-holder: or, Perfect man. Preached in three sermons lately by Ed: Topsell, preacher at Saint Buttolphs without Aldersgate [electronic resource]
No full textPrinter's name from STC.A variant of the 1610 edition (STC 24125).Reproduction of the original in the Bodleian Library.STC (2nd ed.)Electronic reproduction
The historie of serpents. Or, The second booke of liuing creatures wherein is contained their diuine, naturall, and morall descriptions, with their liuely figures, names, conditions, kindes and natures of all venemous beasts: with their seuerall poysons and antidotes; their deepe hatred to mankind, and the wonderfull worke of God in their creation, and destruction. Necessary and profitable to all sorts of men: collected out of diuine scriptures, fathers, phylosophers, physitians, and poets: amplified with sundry accidentall histories, hierogliphicks, epigrams, emblems, and ĂŠnigmaticall obseruations. By Edvvard Topsell.
No full textTimes lamentation: or An exposition on the prophet Ioel, in sundry sermons or meditations
No full textThe house-holder: or, Perfect man. Preached in three sermons lately by Ed: Topsell, preacher at Saint Buttolphs without Aldersgate
No full text
