Разработка технологии изготовления детали «Седло»

Выпускная квалификационная работа включает в себя проектирование технологического процесса обработки детали "Седло" и содержит: анализ чертежа и технологичности детали; способ получения заготовки; расчет припусков на обработку; разработку технологического процесса, выбор и расчет режимов резания; размерный анализ технологического процесса.Final qualifying work includes the design of the technological process of processing details in the "Saddle" and contains: an analysis of drawing and technology details; method of harvesting; calculation of allowances for processing; the design process, the selection and calculation of cutting conditions; dimensional analysis process

Endothelial cells influence the sodium nitroprusside mediated inhibition of platelet aggregation by an as yet unkown pathway

The clinical use of Sodium nitroprusside (SNP) may be associated with an alteration of platelet function. The main focus of this study was the effect of SNP on platelet aggregation in the absence or presence of endothelial cells. Methods: Platelets were incubated with different concentrations of SNP with and without endothelial cells. Platelet aggregation was induced by ADP. Results: Platelet aggregation was significantly inhibited by all concentrations of SNP. Endothelial cells significantly increased this inhibitory effect of SNP. Time course studies showed an inverse correlation of incubation time to platelet aggregation inhibition in the absence of endothelial cells, and a direct correlation in the presence of endothelial cells. Blocking platelet and endothelial cell guanylate cyclase with 1 H-(1,2,4)-oxadiazolo(4,3-a) quinoxalin-1-one (ODQ), or pretreatment of the endothelial cells with cyclooxygenase – inhibitors, had no influence on the increased inhibitory effect of the endothelial cells. Cyanide reversed the inhibitory effect of SNP completely. Conclusion: Endothelial cells play an important role in the SNP mediated inhibition of platelet aggregation. The effect is reversible only by cyanide, not by blocking classical NO signal transduction

Influence of factor XIII activity on post-operative transfusion in congenital cardiac surgery—A retrospective analysis

<div><p>Objectives</p><p>Coagulation factor XIII (FXIII) plays a key role in fibrin clot stabilization—an essential process for wound healing following cardiothoracic surgery. However, FXIII deficiency as a risk for post-operative bleeding in pediatric cardiac surgery involving cardiopulmonary bypass (CPB) for congenital heart disease (CHD) is controversially discussed. Thus, as primary outcome measures, we analyzed the association of pre-operative FXIII activity and post-operative chest tube drainage (CTD) loss with transfusion requirements post-operatively. Secondary outcomes included the influence of cyanosis and sex on transfusion.</p><p>Methods</p><p>Our retrospective analysis (2009–2010) encompassed a single center series of 76 cardio-surgical cases with CPB (0–17 years, mean age 5.61 years) that were post-operatively admitted to our pediatric intensive care unit (PICU). The observational period was 48 hours after cardiac surgery. Blood cell counts and coagulation status, including FXIII activity were routinely performed pre- and post-operatively. The administered amount of blood products and volume expanders was recorded electronically, along with the amount of CTD loss. Uni- and multivariate logistic regression analysis was performed to calculate the associations (odds ratios) of variables with post-operative transfusion needs.</p><p>Results</p><p>FXIII activities remained stable following CPB surgery. There was no association of pre- and post-operative FXIII activities and transfusion of blood products or volume expanders in the first 48 hours after surgery. Similarly, FXIII showed no association with CTD loss. Cyanosis and female sex were associated with transfusion rates.</p><p>Conclusions</p><p>Although essentially involved in wound healing and clotting after surgery, FXIII activity does not serve as a valid predictor of post-operative transfusion need.</p></div

Analysis of the associations between intra-operative volume management and post-operative blood tests / transfusion requirements.

<p>Analysis of the associations between intra-operative volume management and post-operative blood tests / transfusion requirements.</p

Comparison of intra-operative volume management and oxygenator models.

<p>Comparison of intra-operative volume management and oxygenator models.</p

Multivariate logistic regression analysis of post-operative transfusion requirement.

<p>Multivariate logistic regression analysis of post-operative transfusion requirement.</p

Descriptive analysis of post-operative data.

<p>Descriptive analysis of post-operative data.</p