A psoriatic arthritis patient who developed hypertriglyceridemia while receiving adalimumab treatment

Anti-TNF agents have prominent effect on inflammatory diseases and they probably have various effects on lipid metabolism. Adalimumab (ADA) is the first fully human TNF-alfa antagonist. Our study presents a male patient who developed evident hypertriglyceridemia while receiving ADA treatment. We retrospectively collected data of one psoriatic arthritis patient treated with adalimumab at the University Hospital of Recep Tayyip Erdogan (November 2016). Adalimumab treatment significantly increased triglyceride from 278mg/dl to 4046mg/dl. The influence of adalimumab treatment on lipid profile seems to be proatherogenic, but further investigation is needed to confirm this hypothesis

Expressing emotions, rejection sensitivity, and attachment in patients with fibromyalgia

Objectives: This study aimed to examine emotional awareness, control of emotions, and the childhood attachment process in fibromyalgia patients. Patients and methods: The observational study was conducted with 117 participants (14 males, 103 females; mean age: 43.9±9.0 years; range, 22 to 64 years) between February 20, 2022, and May 20, 2022. Sixty-one patients and 56 healthy control subjects filled out a form including sociodemographic data, such as age, sex, occupation, and educational status. In addition, the participants answered the Expressing Emotions Scale, Rejection Sensitivity Scale, and Experiences in Close Relationships Scale. Results: In our study, Expressing Emotions Scale scores are significantly higher in the healthy control group than in the patient group (p<0.05). Rejection Sensitivity Scale scores are significantly higher in the patient group than in the healthy control group (p<0.05). In the Experiences in Close Relationships Scale, a significant difference was determined between the patient and control groups in the avoidant attachment subdimension (p<0.05). Similarly, a significant difference was observed between both groups in terms of the anxiety attachment subdimension (p<0.05). Conclusion: The ability to express emotions is lower and avoidant and anxious attachment rates are higher in fibromyalgia patients

Fibromiyaljinin Migrenli Hastalarda Dizabilite, Anksiyete, Depresyon, Uyku Bozukluğu ve Yaşam Kalitesi Üzerine Etkisi

Introduction: The aim of the present study was to assess the impact of fibromyalgia (FM) comorbidity on disability, anxiety, depression, sleep disturbance, and quality of life in patients with migraine. Methods: Eighty-six consecutive migraine patients (age, 35.4±10.3 years; 69 women and 17 men) were enrolled in the study. The headache characteristics of the patients were recorded. FM was diagnosed based on the 1990 American College of Rheumatology classification criteria for the diagnosis of FM. All patients were asked to complete selfreport questionnaires, including the Fibromyalgia Impact Questionnaire (FIQ), Headache Impact Test (HIT-6), Migraine Disability Assessment Questionnaire (MIDAS), Pittsburgh Sleep Quality Index (PSQI), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and the 36- Item Short Form Survey (SF-36) to assess their pain-related disability, migraine-related disability, depression, anxiety, sleep disturbance, and quality of life. Results: Of the migraine patients, 28 (32.6%) met the criteria for FM. Migraine patients with FM showed significantly increased migraine frequency and BDI, BAI, and PSQI scores and decreased quality of life scores for all eight domains of the SF-36 compared to patients with migraine alone, whereas the mean HIT-6 and MIDAS values did not differ between the groups. FIQ score showed statistically significant positive correlations with BDI, BAI, PSQI, and MIDAS scores and with headache frequency (p<0.001, r=0.657; p<0.001, r=0.730; p<0.001, r=0.754; p=0.005, r=0.300; p=0.008, r=0.286, respectively); FIQ score showed negative correlations with scores for all domains of the SF36. In multivariate linear regression analysis, BDI, BAI, and PSQI scores independently predicted FIQ score. Conclusion: Our study results demonstrate the significant impact of FM comorbidity on anxiety, depression, sleep disturbance, and quality of life in this population. FM evaluation and treatment should be considered in the routine care of patients with migraine to globally improve the patient’s quality of life.Amaç: Sunulan bu çalışmanın amacı migrenli hastalarda fibromiyalji (FM) birlikteliğinin dizabilite, anksiyete, depresyon, yaşam kalitesi ve uyku bozukluğu üzerindeki etkilerini değerlendirmek idi. Yöntem: Seksenaltı ardışık migren hastası çalışmaya dahil edildi. Hastaların migren baş ağrısı karakteristikleri kaydedildi. FM tanısı 1990 Amerikan Romatizma Cemiyeti’nin FM tanı kriterlerine göre koyuldu. Ağrı ve migren ile ilişkili dizabilite, depresyon, anksiyete, uyku bozukluğu ve yaşam kalitesi tespiti için tüm hastaların Migren Dizabilite Değerlendirme Ölçeği (MDDÖ), Fibromiyalji Etki Sorgulaması (FES), Baş Ağrısı Etki Testi-6 (BET-6), Pittsburgh Uyku Kalite Indeksi (PUKİ), Beck Depresyon Envanteri (BDE), Beck Anksiyete Envanteri (BAE) ve Kısa Form 36’yı (KF-36) içeren hasta bildirimli sorgulama formlarını tamamlamaları istendi. Bulgular: Migren hastalarının 28’i (%32,6) FM tanı kriterlerini karşıladı. Ortalama BET-6 ve MDDÖ değerleri gruplar arasında farklı değilken, migrenle birlikte FM’ye sahip olan hastalar yalnızca migrene sahip olan hastalara göre artmış baş ağrısı sıklığı ve artmış BDE, BAE, PUKİ ve MDDÖ skorları ve KF-36’nın tüm alt grupları için azalmış yaşam kalitesi skorları gösterdiler. FES skorları BDE, BAE, PUKİ, MDDÖ skorları ve baş ağrısı sıklığı ile istatiksel olarak anlamlı pozitif korelasyon (p<0,001, r=0,657; p<0,001, r=0,730; p<0,001, r=0,754; p=0,005, r=0,300; p=0,008, r=0,286, sırasıyla) ve KF-36’nın tüm alt grupları ile negatif korelasyon gösterdi. Çok değişkenli lineer regresyon analizinde BDE, BAE ve PUKİ skorları FES skorlarını bağımsız şekilde tespit etti. Sonuç: Çalışmamızın sonuçları migrenli hastalarda FM birlikteliğinin anksiyete, depresyon, uyku bozukluğu ve yaşam kalitesi üzerindeki önemli etkilerini açığa çıkardı. Hastaların yaşam kalitesinde tümüyle iyileşme sağlamak için, FM incelemesi ve tedavisi migrenli hastaların rutin takibinde dikkate alınmalıdır