First-line treatment of patients with HER2-positive metastatic gastric and gastroesophageal junction cancer

Fluoropyrimidine+cisplatin/oxaliplatin+trastuzumab therapy is recommended for the first-line treatment of HER2-positive metastatic gastric adenocarcinoma. However, there is no comprehensive study on which platinum-based treatment should be preferred. This study aimed to compare the treatment response and survival characteristics of patients with HER2-positive metastatic gastric or gastroesophageal junction (GEJ) cancer who received fluorouracil, oxaliplatin, and leucovorin (mFOLFOX)+trastuzumab or cisplatin and fluorouracil (CF)+trastuzumab as first-line therapy. It was a multicenter, retrospective study of the Turkish Oncology Group, which included 243 patients from 21 oncology centers. There were 113 patients in the mFOLFOX+trastuzumab arm and 130 patients in the CF+trastuzumab arm. The median age was 62 years in the mFOLFOX+trastuzumab arm and 61 years in the CF+trastuzumab arm (P = 0.495). 81.4% of patients in the mFOLFOX+trastuzumab arm and 83.1% in the CF+trastuzumab arm had gastric tumor localization (P = 0.735). The median progression-free survival (PFS) was significantly higher in the mFOLFOX+trastuzumab arm (9.4 months vs. 7.3 months, P = 0.024). The median overall survival (OS) was similar in both groups (18.4 months vs. 15.1 months, P = 0.640). Maintenance trastuzumab was continued after chemotherapy in 101 patients. In this subgroup, the median OS was 23.3 months and the median PFS was 13.3 months. In conclusion, mFOLFOX+trastuzumab is similar to CF+trastuzumab in terms of the median OS, but it is more effective in terms of the median PFS in the first-line treatment of HER2-positive metastatic gastric and GEJ cancer. The choice of treatment should be made by considering the prominent toxicity findings of the chemotherapy regimens

Production and characterization of zinc oxide nanofibers derived from waste material as precursor

WOS:000999373400001The emergence of industrial wastes brings with it a series of global environment issues. However, using these wastes including valuable metals as a source of value-added materials will lead to many advantages. The metals can be recovered and transformed for nanomaterial production which offers utility in many applications such as energy conversion and hydrogen evaluation. In this study, recycling techniques were used to synthesize zinc oxide nanofibers from waste brass flue dust. Initially, characterization and experimental analyses were used to confirm the synthesized nanofibers phase purity, morphology, and optical properties. The X-Ray diffraction (XRD) analysis and X-ray photoelectron spectroscopy (XPS) confirmed the nanofibers produced after recycling process were predominantly ZnO and have high purity. It was determined from scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analysis that the produced samples were in fiber form in nanoscale and high crystallinity. According to the ultraviolet visible spectroscopy (UV-Vis) analysis, the optical band of ZnO nanofibers was found as 3.19 eV. It has been demonstrated with this study that the ZnO nanofibers derived from industrial waste can be used in several energy applications. Also, it was revealed that metal-containing wastes can be disposed of by producing value-added nanomaterials directly from industrial wastes with economical value

Bakır anot çamurlarındaki Au, Ag ve Cu metallerinin geri kazanımında çevreye duyarlı yeni çözücülerin araştırılması

TEZ 669.3/TOPbKaynakça: 71-77 ss.[Özet Yok

Simple and selective copper recovery from valuable industrial waste by imidazolium based ionic liquids with BF4- anions

WOS:000907008600006In this study, copper was recovered selectively with hydrometallurgical routes (leaching and cementation) from copper anode slime which is a valuable industrial waste. The use of 1-butyl-3-methylimidazolium tetrafluoroborate (BmimBF4) ionic liquid as a novel solvent has been systematically investigated. As a result of the leaching experiment, 98.4% of copper was leached at the optimum leaching conditions; ionic liquid concentration as 40%, temperature as 95 ºC, time as 12 h solid/liquid ratio as 1/25 g/mL and, addition of 20% HBF4 as an oxidant. Also, the experimental results revealed that the other elements in the copper anode slime were not soluble in BmimBF4/HBF4. Moreover, the copper was extracted from the leach solution as in metallic form with the cementation. The highest copper extraction rate was achieved as 93.3% at 45 ºC and 120 min using a scrap aluminum sheet. After all, 91.8% of copper was recovered from copper anode slime as metallic form by leaching and cementation processes in BmimBF4/HBF4. Also, it was found that the leach solution can be reused at least 5 times with low deviations

Investigation of use of deep eutetic solvent on copper recovery from copper anode slag

Bu çalışmada, ikincil kaynaklardan bakır tel üretimi yapan bir firmadan temin edilen bakır anot cürufundan bakır geri kazanımı için çevre ve insan sağlığına duyarlı düşük erime noktalı çözücü kullanımı araştırılmıştır. Bakır anot cürufunun fiziksel, kimyasal ve mineralojik karakterizasyonu öncesinde yapılan öğütme işleminde cüruf içindeki metalik bakırın bir kısmı fiziksel olarak ayrılmıştır. Liç deneylerinde son yıllarda hidrometalurjik süreçlerde kullanılan kolin klorür (ChCl) ve üre (1:2) ile hazırlanan düşük erime noktalı solvent çevre duyarlı çözücü olarak kullanılmıştır. Liç deneylerinin sonuçlarına göre fiziksel olarak anot cürufundan ayrılmayan bakır 72 saatlik reaksiyon süresi, 95 oC’lik liç sıcaklığı ve 1/20 katı/sıvı oranı şartlarındaki liç işlemi ile %90 üzerinde ekstrakte edilmiştir. Liç deneylerinden sonrasında çözeltideki demir çözünürlüğünün oldukça düşük seviyede kaldığı görülmüştür. Çalışmada elde edilen sonuçlara göre fiziksel olarak ayırma ve sonrasında ChCl-üre karışımıyla hazırlanan düşük erime noktalı çözücü kullanılarak yapılan liç işlemleri ile bakır anot cürufundan bakır geri kazanımı için çevreci bir çözücü adayı olabileceği ortaya konmuştur.In this study, a deep eutectic solvent which is sensitive to environmental and human health was used for copper recovery from copper anode slime. Metallic copper was obtained after grinding process which performed before leaching experiments and physical, chemical and mineralogical characterization of copper anode slag. In the leaching experiments, a deep eutectic solvent prepared with choline chloride and urea (1:2) that used in hydrometallurgical processes in recent years was used as environmentally sensitive solvent. According to the results of the leaching experiments, copper, which is not separated from the anode slag mechanically, was extracted as approximately 90% after the leaching test performed at 72 hours of reaction time, 95 oC of reaction temperature and 1/20 of solid/liquid ratio. After all the leaching experiments, iron solubility remained very low. As result of this work, it has been demonstrated that physical separation and leaching with deep eutectic solvent can be used as an environmentally friendly process for copper recovery from copper anode slag

Investigation of an alternative chemical agent to recover valuable metals from anode slime

WOS:000441699600018Anode slime (AS) including high content of precious metals is a by-product obtained after the electro-refining stage in copper production. In this study, it is aimed to recover Cu, Au, and Ag from the AS by using 1-butyl-3-methyl-imidazolium hydrogen sulphate ([Bmim]HSO4) ionic liquid (IL) as a green solvent. The effects of IL concentration, temperature, reaction time and pulp density on recovery of valuable metals were statistically investigated. A high copper recovery of 87.52% was obtained under optimum condition as in 60% (v/v) [Bmim]HSO4 at 50 A degrees C after 2 h, pulp density at 40 g/L (1/25 solid/liquid ratio). Also, a remarkable gold recovery as 97.32% has been achieved in 80% (v/v) [Bmim]HSO4 at 95 A degrees C after 4 h, pulp density at 40 g/L. Temperature and IL concentration were detected as the most effective parameters for copper and gold recovery from AS, respectively. Silver could not be recovered from the AS due to the lower solubility in [Bmim]HSO4 IL media. According to experimental results, [Bmim]HSO4 could be offered as an alternative leaching agent, instead of conventional solvents, to recover valuable metals from copper anode slime.Karamanoglu Mehmetbey University Scientific Research Projects (BAP) Coordinating OfficeKaramanoglu Mehmetbey University [04-YL-16]This work was supported by Karamanoglu Mehmetbey University Scientific Research Projects (BAP) Coordinating Office with project no 04-YL-16

The effect of EmimHSO4 (1-Ethyl-3-Methyl-İmidazolium Hydrogen Sulfate) on copper recovery from anode slime

Bu çalışmada, Türkiye’de ikincil atıklardan üretim yapan bir firmadan tedarik edilen ve %23.1 Cu, %20.5 Sn ve %15.4 Pb temel kimyasal kompozisyonuna sahip anot çamurundan bakır geri kazanımı için çevreye duyarlı yeni bir çözücü olan 1-etil-3-metil-imidazolyum hidrojen sülfat (EmimHSO4 ) iyonik sıvısı kullanımı araştırılmıştır. Yapılan deneysel çalışmalarda, bakır geri kazanımını etkileyen iyonik sıvı konsantrasyonu, sıcaklık, süre ve katı/sıvı oranı parametreleri incelenerek bakır için optimum geri kazanım koşulları Taguchi metodu ile belirlenmiştir. Varyans analizi yöntemi (ANOVA) kullanılarak optimum koşullar altında, bakır geri kazanımı için en etkili parametreler belirlenmiştir. Elde edilen sonuçlara göre bakır kazanımı için optimum koşullar; iyonik sıvı konsantrasyonu: %60, sıcaklık: 95 o C, süre: 2 saat ve katı/sıvı oranı: 1/20 olarak tespit edilmiştir. Bakır kazanımı için en etkili parametrelerin sırasıyla, reaksiyon süresi, sıcaklık, katı/sıvı oranı ve iyonik sıvı konsantrasyonu olduğu belirlenmiştir.In this present study, a new solvent called 1-ethyl-3-methyl-imidazolium hydrogen sulphate (EmimHSO4 ) was used for recovery of copper from anode slime. Sample whose compounds are mainly of 23.1% Cu, 20.5 %Sn and 15.4% Pb was provided from a copper refining plant making production from secondary grade wastes in Turkey. The optimum metal recovery conditions for copper including ionic liquid concentration, temperature, time and solid/liquid ratio which affect the leaching efficiency were investigated in the experiments were detected by Taguchi method. Also, the most effective parameters under the optimum conditions for copper metal recovery were determined by analysis of variance method (ANOVA). According to the experimental results, optimum conditions for copper recovery were found as for ionic liquid concentration; 60%, for temperature; 95 o C, for time; 2 hours and for solid/liquid ratio; 1/20. The most effective parameters determined as leaching duration, temperature, pulp density (solid/liquid ratio) and ionic liquid concentration, respectively

Investigation of zinc extraction from different leach residues by acid leaching

WOS:000419171400006With different properties, zinc is one of the most important non-ferrous metals and it is used in various application areas, especially as an anti-corrosion agent. In Turkey, zinc production was based on zinc carbonate ores (ZnCO3), at Cinkur plant from establishment to 1997 due to high reserves of zinc carbonate. After that, zinc concentrate coming from Iran was used in this plant over the last two decades. Thus, two different leach residues called as Turkish leach residue (TLR) and Iranian leach residue (ILR) were accumulated more than one million ton in Cinkur stock piles. In this study, it is aimed to investigate zinc recovery for each leach residue by use of sulphuric acid (H2SO4) and to compare the TLR and the ILR. Initially, detailed chemical, mineralogical and thermal analyses of these different leach residues were carried out. In order to investigate the effect of acid concentration and reaction duration on zinc recovery, leaching experiments were carried out at following conditions: 95 A degrees C, 100 g/L pulp density and 600 rpm stirring rate. According to the characterization results, the chemical compositions for both residues are nearly similar; however, experimental results show that zinc recovery per cent of the ILR was higher than that of TLR for all experimental durations and acid concentrations. This may be due to the presence of Zn-containing compounds in the both residues at different percentages.Karamanoglu Mehmetbey UniversityKaramanoglu Mehmetbey University [KMU-BAP-04-M15]Funding was provided by Karamanoglu Mehmetbey University (Grant No. KMU-BAP-04-M15)

Optimization of gold recovery from copper anode slime by acidic ionic liquid

WOS:000415006800017Hydrometallurgical gold recovery from primary or secondary sources is mainly based on a cyanide process, which is very dangerous for the environment due to the high toxicity levels. In view of the environmental effect, the present study proposes a new green solvent called 1-ethyl-3-methyl-imidazolium hydrogen sulfate (EmimHSO(4)) ionic liquid (IL) to recover gold from copper anode slime (CAS). The optimum leaching conditions for maximizing gold recovery were determined by orthogonal array (OA) of Taguchi's experimental design method. OA L-16 (4(4)) including four parameters with four levels each, was used to examine the effects of IL concentration (20%, 40%, 60%, 80% v/v), temperature (25, 50, 75, 95 A degrees C), time (A 1/2, 1, 2, 4 h) and solid/liquid ratio (1/10, 1/15, 1/20, 1/25 g/mL) on leaching efficiency of the gold recovery. Statistical analysis of variance (ANOVA) was used to determine the relevance between experimental conditions and gold recovery. The selective leaching tests results showed that gold recovery up to 89.07% was attained on laboratory scale under the optimum leach conditions: 80% IL concentration, 75 A degrees C, 4 h and 1/25 g/mL solid/liquid ratio. According to these results, EmimHSO(4) IL provides a very good ambiance for the oxidative leaching of gold and can be offered as an alternative leaching agent instead of harmful cyanide-based solvents.Karamanoglu Mehmetbey University Scientific Research Projects (BAP) Coordinating OfficeKaramanoglu Mehmetbey University [KMU-BAP-04-M-15]The authors gratefully acknowledge the Karamanoglu Mehmetbey University Scientific Research Projects (BAP) Coordinating Office for support with grant number KMU-BAP-04-M-15

Investigation of use of deep eutectic solvent on copper leaching from copper anode slime

Bu çalışmada, pirometalurjik yöntemle metalik bakır üretiminin elektrokazanım aşamasında ortaya çıkan anot çamurundan bakır geri kazanımı üzerine çevre ve insan sağlığına duyarlı düşük ötektik noktalı çözücü (DES) kullanımı araştırılmıştır. Taguchi optimizasyon yöntemi kullanılarak liç sıcaklığı, liç süresi ve katı/sıvı oranı deneysel parametrelerin bakır geri kazanımı üzerine etkisi incelenmiştir. Kolin klorür (ChCl) ve ürenin 1:2 molar oranda karıştırılmasıyla hazırlanan DES çözücüsü ile yapılan liç işlemleri sonunda optimum şartlar; 95 oC’liç sıcaklığı, 2 saat liç süresi ve 1/20 katı/sıvı oranı olarak belirlenmiş ve bu şartlarda %98 bakır geri kazanımı elde edilmiştir. Yapılan bu çalışma ile ChCl-üre karışımıyla hazırlanan DES çözücüsünün anot çamurundan bakır geri kazanımı için çevreci bir çözücü adayı olabileceği ortaya konulmuştur.In this study, use of environmentally and human health sensitive solvent, called deep eutectic solvent (DES), was investigated for copper recovery from anode slime which was produced during electrorefining stage of the metallic copper production by pyrometallurgical method. The effect of experimental parameters was investigated using the Taguchi optimization method. At the end of the leaching process with DES solvent prepared by mixing ChCl and urea in 1:2 molar ratio, optimum conditions were determined as; 95 oC leaching temperature, 2 hours leaching time and 1/20 solid/liquid ratio and 98% copper recovery was obtained under this condition. With this study, it has been revealed that DES prepared by ChCl-urea mixture can be an environmentally friendly solvent candidate for copper recovery from anode slime