PREVALENCE OF ASTHMA, RELATED SYMPTOMS AND RISK FACTORS IN CHILDREN YOUNGER THAN 5 YEARS

Asthma is the most prevalent chronic disease in childhood. To determine the prevalence of asthma and related symptoms in children younger than 5 years, a survey was performed by interviewing mothers of 617 children during spring 2001. The interview comprised of two parts. The first part contained children characteristics including age, sex, maternal age at the child birth, child history of atopy, maternal history of smoking during pregnancy, existence of household smoker, history of family asthma or family atopy. The second part contained asthma section of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. The overall cumulative and 12 month prevalences of wheezing were 21.9% and 19.4%, respectively. The prevalences of exercise-induced wheezing, dry cough without respiratory infections or physician-diagnosed asthma were 18.9%, 11.8% and 3.9%,respectively. Multiple logistic regression analysis showed a higher prevalence of history of wheezing or exercise-induced wheezing in male sex and in the children with positive history of atopy. Persistent cough unrelated to respiratory infections was strongly associated with the positive history of atopy in the children or maternal age at the child birth less than 20 yr or more than 30 yr. Furthermore a physician-diagnosed asthma was significantly associated with positive history of atopy in child. The results suggest a relatively high prevalence of history of wheezing or current and exercise-induced wheezing, but underdiagnosis of asthma among studied children needs more studies to be confirmed

A study of circumcision prevalence and complications in under 5 year old boys in Galleno village-Shahre Ray, Jan 1997

To determine circumcision prevalence and complications in under 5 year old boys. We assessed 181 boys in a cross sectional study at a rutal area in Tehran suburbs, in Jan 1997. Data were collected by an interview about age, circumcision age and method, type of complications, nationality and parent literacy. 126 boys (69%) were circumcised, (mean 12 months). Only 27 of them (21.4%) were circumcised in neonatal period. 62 boys (49.2%) were circumcised with ring methods (plastibell or clamp), 54 boys (42.9%) with surgical methods and the others (7.9%) with nonmendical methods (traditional). Complications were 9.5% (16) and the higher circumcision age was related significantly with higher complications (P<0.04). In our study was no complication in the boys who circumcised under six months. Complications prevalence were high (9.5%). In neonatal period 34% (9) and in postneonatal period 53% (52) of boys were circumcised with inappropriate methods with age. The most common complications were local infection (43%

Demographic aspects, clinical characteristics, and therapeutic approaches in geriatric psoriasis: A study from a tertiary center

Geriatric psoriasis, due to its unusual clinical manifestations and higher rates of systemic complications in this age group, is a challenging issue for dermatologists. Therefore, we aimed to provide an overview of the epidemiological, clinical, and therapeutic consequences among patients aged over 60 years with psoriasis in a referral center in Iran. This cross-sectional study was conducted on 156 patients over 60 years with the definitive diagnosis of psoriasis that were referred to our center between 2015 and 2019. By reviewing the recorded files of the patients, baseline characteristics including demographics, underlying comorbidities, age of disease onset, clinical type of the disease, clinical manifestations, and therapeutic approaches were extracted. The most common clinical feature was plaque type (73.1) followed by pustular type (10.9). The most frequent involved zone was the lower extremities (84.6). Most of the patients were treated topically (87.1), while as the most frequent systemic approaches, methotrexate and acitretin were considered for 74.4 and 60.3, respectively. A significantly higher mean age at disease onset was found in female patients compared to male patients. The plaque type was more prevalent in men than in women. Also, the chance of nail involvement was 2.43 times higher in men than in women (p = 0.011, 95CI: 1.22�4.84). The disease duration was significantly longer in patients suffering from plaque compared to those without this feature. Conversely, those with palmoplantar type experienced shorter disease duration. Psoriatic arthritis was also revealed in patients of lower ages. As in other societies, in our society, clinical characteristics, disease involvement patterns, as well as considered treatment approaches, can be influenced by demographic characteristics. © 2022 Wiley Periodicals LLC

Toward Reversible Control of Cucurbit[ n

CONSPECTUS: The cucurbit[n]uril (CBn) host family consists of a group of rigid macrocyclic hosts with barrel-like shapes and limited solubility in aqueous media. These hosts are capable of reaching high binding affinities with positively charged hydrophobic guests. In optimum cases, equilibrium association constant (K) values as high as 10(17) M(-1) have been reported, exceeding the binding affinity of the avidin-biotin host-guest pair. The synthetic CBn receptors have shattered the notion that highly stable noncovalent complexes can form only when one of the partners is a molecule of biological origin. The work described in this Account is concerned with the development of methods geared toward the reversible modulation of the binding affinity of CBn inclusion complexes under mild conditions. A good fraction of the research work has dealt with redox active guests, such as 4,4'-bipyridinium (viologen), ferrocene, and cobaltocenium derivatives. Our experimental results show that the thermodynamics and kinetics of the electron transfer reactions of these compounds can be substantially altered by complexation with CBn hosts, and therefore, electron transfer reactions can be used to exert a measure of control on the overall binding affinity of the CBn complexes. We have also developed systems in which proton transfer reactions have a strong effect on the binding affinity. With more structurally elaborate guests containing more than one adjacent binding sites, proton transfer reactions may affect the average location of the CBn host within the complexes. A series of guest compounds containing paramagnetic 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) residues also exhibit interesting binding properties with CB7 and CB8. The latter host forms a very stable host-guest pair with TEMPO subunits, in which the nitroxide group resides inside the host cavity. Finally, with suitable ditopic guests, we have detected distinct microscopic complexes using experimental techniques with relatively slow time scales, such as NMR spectroscopy. These unusual findings are the result of the considerable thermodynamic and kinetic stability of CBn inclusion complexes