11 research outputs found
Expression of the IFN Gene Signature.
<p><b>Key:</b><sup>a,</sup>ISRE-driven ISGs, <sup>b</sup> ISRE-driven ISGs potentially regulated by NF-κB, <sup>c</sup> SIE-driven ISGs, and <sup>d</sup> SIE-driven ISGs potentially regulated by NF-κB.</p
Logistic regression modeling of patient data.
<p>*OR for gene expression is for a change of 10 units.</p
Differential expression of an IFN-regulated signature geneset in relapsers versus responders to IFN-ribavirin therapy to therapy.
<p>Expression of an IFN signature geneset was determined in RNA extracted from FFPE liver biopsies by nCounter analysis. Boxplots of genes found to be statistically differentially expressed by nonparametric Mann-Whitney analysis (p<0.05).</p
Genes in IRF activation by cytosolic pattern recognition receptors are associated with IFN responsiveness.
<p>The gene network was generated using Ingenuity Pathway Analysis software. Genes upregulated in nonresponders (shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0104202#pone-0104202-g001" target="_blank">Figure 1</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0104202#pone-0104202-g002" target="_blank">2</a>) were highlighted.</p
Genes in the pattern recognition receptor pathway are associated with IFN responsiveness.
<p>The gene network was generated using Ingenuity Pathway Analysis software. Genes upregulated in nonresponders (shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0104202#pone-0104202-g001" target="_blank">Figure 1</a>) were highlighted. As expected, several antiviral signaling pathways were overrepresented in these genes.</p
Differential expression of an IFN-regulated signature geneset in responders versus nonresponders to therapy.
<p>Expression of an IFN-regulated signature geneset was determined in RNA extracted from FFPE liver biopsies by nCounter analysis. Boxplots of genes found to be statistically differentially expressed by nonparametric Mann-Whitney analysis (p<0.05).</p
Signaling networks of genes that are associated with IFN responsiveness.
<p>The gene network was generated using Ingenuity Pathway Analysis software.</p
The distribution of predicted probability of therapeutic response (with relapsers included).
<p>We found that those who actually responded to IFN-ribavirin treatment had higher predicted probabilities of response in the model.</p