Adoptive T-cell therapy improves treatment of canine non–Hodgkin lymphoma post chemotherapy

Clinical observations reveal that an augmented pace of T-cell recovery after chemotherapy correlates with improved tumor-free survival, suggesting the add-back of T cells after chemotherapy may improve outcomes. To evaluate adoptive immunotherapy treatment for B-lineage non-Hodgkin lymphoma (NHL), we expanded T cells from client-owned canines diagnosed with NHL on artificial antigen presenting cells (aAPC) in the presence of human interleukin (IL)-2 and IL-21. Graded doses of autologous T cells were infused after CHOP chemotherapy and persisted for 49 days, homed to tumor, and significantly improved survival. Serum thymidine kinase changes predicted T-cell engraftment, while anti-tumor effects correlated with neutrophil-to-lymphocyte ratios and granzyme B expression in manufactured T cells. Therefore, chemotherapy can be used to modulate infused T-cell responses to enhance anti-tumor effects. The companion canine model has translational implications for human immunotherapy which can be readily exploited since clinical-grade canine and human T cells are propagated using identical approaches

PERMANENT MAGNET FOCUSING SYSTEM FOR KLYSTRONS

Abstract The Distributed Klystron Scheme for ILC requires thousands of klystrons. The failure rate of each klystron may be a critical issue for a stable operation of the ILC. In order to eliminate the power supplies and the cooling system for the solenoid focusing coils, a permanent magnet beam focusing system is under development. Since the required magnetic field is not high in this system, inexpensive anisotropic ferrite magnets can be used instead of magnets containing rare earth materials

Design and measurement of a combined function magnet intended for a cancer therapy accelerator

A compact proton synchrotron using combined function magnets is proposed to help realize the wider availability of charged particle cancer therapy facilities. This combined function magnet was designed with the help of three-dimensional magnetic field calculations to take account of a realistic fringe and the interference among the magnetic poles. An evaluation scheme for tune values based on particle tracking was developed to improve the magnet design. To verify the magnet design, a model magnet was fabricated and measured. In order to achieve a tune value evaluation from the measured magnetic field, schemes for accurate field mapping and field interpolation were developed. From the tune value evaluation of the measured magnetic field, it was thought that the performance of the model magnet was good enough to construct a synchrotron. In this paper, we report details of the design and the evaluation scheme for the combined function magnet and the results of the field measurements of the model magnet

THE PRESENT STATUS OF THE VACUUM SYSTEM IN KSR

Abstract In order to reduce the aging time for the beam storage, improvement and upgrade of the vacuum system for KSR had been carried out at the end of 2001. Then the beam storage with high current without the acceleration is realized. The beam lifetime ware studied. It is considered that the beam lifetime decrease appreciably by the ion trappin

MULTIPACTOR SIMULATIONS IN 650MHz SUPERCONDUCTING SPOKE CAVITY FOR AN ELECTRON ACCELERATOR

レーザーコンプトン散乱を用いた小型で産業利用可能なX 線源を実現するため、電子加速器用の325MHz 超伝導スポーク空洞の開発を行っている。空洞形状の最適化は遺伝的アルゴリズムを用いて行っており、詳細設計を行うためにマルチパクターの計算を現在行っている。さらに製作に向けての検討も行っているので、それらについて発表を行う

STUDY ON NONDESTRUCTIVE INSPECTIONS FOR SUPERCONDUCTING CAVITY

ERLとレーザーコンプトン散乱を用いた光源のための電子ビーム加速器の開発を行っている。スポーク空洞の利点を生かせば、ERL 加速器の小型化が期待できるため、LCS-γ/X線源を産業・学術分野に利用していくための小型加速器の候補として超伝導スポーク空洞の開発を進めている。空洞の高周波試験の際に必要となるX線や温度分布を計測するためのマッピングシステムの検討を行っているので、その現状について報告する