Stability of peakons and periodic peakons for a nonlinear quartic Camassa-Holm equation

In this paper, we study the orbital stability of peakons and periodic peakons for a nonlinear quartic Camassa-Holm equation (QCHE).We first verify that the QCHE has global peakon and periodic peakon solutions. Then by the invariants of the equation and controlling the extrema of the solution, we prove that the shapes of the peakons and periodic peakons are stable under small perturbations in the energy space

Pregnancy outcomes in infertile patients with endometrial hyperplasia with or without atypia undergoing in vitro fertilization: the early-follicular long protocol is superior to midluteal long protocol

BackgroundAlthough in vitro fertilization (IVF) in infertile patients with endometrial hyperplasia is common after drug treatment, the pregnancy outcomes are often unsatisfactory. Till date, no studies have reported the outcome of patients with endometrial hyperplasia treated using early-follicular long (EL) protocol and midluteal long (ML) protocol.ObjectiveTo evaluate the pregnancy outcomes and disease prognosis of patients with endometrial hyperplasia with or without atypia undergoing IVF treatment with EL protocol or ML protocol.MethodsThis was a retrospective study in university-affiliated reproductive medical center. A total of 138 patients with endometrial hyperplasia undergoing IVF treatment were included to compare the pregnancy outcomes and disease prognosis between EL and ML protocols. We further matched 276 patients with normal endometrium to compare the pregnancy outcomes between patients with endometrial hyperplasia and patients with normal endometrium under different controlled ovarian stimulation (COS) protocol.ResultsIn patients with endometrial hyperplasia, the clinical pregnancy rate (CPR) and live birth rate (LBR) were significantly higher in EL protocol than in ML protocol (61.8% vs. 43.5%, P=0.032; 50.0% vs. 30.6%, P= 0.022). In the ML protocol, patients with endometrial hyperplasia had significantly lower CPR and LBR than those with normal endometrium (43.5% vs. 59.7%, P=0.037; 30.6% vs. 49.2%, P=0.016). While in the EL protocol, they achieved similar CPR and LBR as patients with normal endometrium (61.8% vs. 69.7%, P=0.232; 50.0% vs. 59.9%, P=0.156). In patients with endometrial hyperplasia, COS protocol was an independent factor affecting clinical pregnancy (adjusted odds ratio [OR] 2.479; 95% confidence interval [CI] 1.154-5.327) and live birth (adjusted OR 2.730; 95% CI 1.249-5.966). After 1–10 years of follow-up, no significant difference was found in the recurrence rate of endometrial lesions between both treatment groups.ConclusionsFor patients with endometrial hyperplasia undergoing IVF treatment, the EL protocol is superior to ML protocol, and in the EL protocol, they can achieve similar pregnancy outcomes as patients with normal endometrium

Effect of Methyl Jasmonate Combined with Calcium Chloride Treatment on Storage Quality of Dictyophora rubrovalvata

The aim of this study was to investigate the effects of combined treatment of methyl jasmonate and calcium chloride on storage quality of Dictyophora rubrovalvata. The Dictyophora rubrovalvata was used as the experimental material in this experiment, and the effects of different dealing methods (preharvest distilled water spray treatments mark CK, preharvest 3% calcium chloride spray (S1), preharvest 0.3 mmol/L methyl jasmonate spray (S2), preharvest 0.3 mmol/L methyl jasmonate+3% calcium chloride spray (S3)) on the storage quality of Dictyophora rubrovalvata at (1±0.5) ℃ were studied. The results showed that compared with CK group, the different treatment groups could inhibit the increase of weight loss rate and respiratory intensity, reduce the Dictyophora rubrovalvata shearing force, malondialdehyde content, maintain the free amino acid content, protein content, polysaccharide content and flavone content, and maintain the SOD, CAT and POD activity of the Dictyophora rubrovalvata. At 12 d of storage, the decay rate of Dictyophora rubrovalvata in CK, S1, S2 and S3 groups was 32.56%, 28.32%, 19.85% and 14.64%, and the weight loss rate was 5.62%, 3.89%, 2.89% and 2.21%. In general, methyl jasmonate combined with calcium chloride could significantly delay the deterioration process of Dictyophora rubrovalvata and the decline of its storage quality. Therefore the combination of spraying methyl jasmonate combined with calcium chloride before picking had the best fresh-keeping effect, which could maintain the storage effect of Dictyophora rubrovalvata. This study can provide theoretical reference and technical support for the preservation of Dictyophora rubrovalvata

OP9-Lhx2 stromal cells facilitate derivation of hematopoietic progenitors both in vitro and in vivo

AbstractGenerating engraftable hematopoietic stem cells (HSCs) from pluripotent stem cells (PSCs) is an ideal approach for obtaining induced HSCs for cell therapy. However, the path from PSCs to robustly induced HSCs (iHSCs) in vitro remains elusive. We hypothesize that the modification of hematopoietic niche cells by transcription factors facilitates the derivation of induced HSCs from PSCs. The Lhx2 transcription factor is expressed in fetal liver stromal cells but not in fetal blood cells. Knocking out Lhx2 leads to a fetal hematopoietic defect in a cell non-autonomous role. In this study, we demonstrate that the ectopic expression of Lhx2 in OP9 cells (OP9-Lhx2) accelerates the hematopoietic differentiation of PSCs. OP9-Lhx2 significantly increased the yields of hematopoietic progenitor cells via co-culture with PSCs in vitro. Interestingly, the co-injection of OP9-Lhx2 and PSCs into immune deficient mice also increased the proportion of hematopoietic progenitors via the formation of teratomas. The transplantation of phenotypic HSCs from OP9-Lhx2 teratomas but not from the OP9 control supported a transient repopulating capability. The upregulation of Apln gene by Lhx2 is correlated to the hematopoietic commitment property of OP9-Lhx2. Furthermore, the enforced expression of Apln in OP9 cells significantly increased the hematopoietic differentiation of PSCs. These results indicate that OP9-Lhx2 is a good cell line for regeneration of hematopoietic progenitors both in vitro and in vivo

Human respiratory syncytial virus subgroups A and B outbreak in a kindergarten in Zhejiang Province, China, 2023

BackgroundIn May–June 2023, an unprecedented outbreak of human respiratory syncytial virus (HRSV) infections occurred in a kindergarten, Zhejiang Province, China. National, provincial, and local public health officials investigated the cause of the outbreak and instituted actions to control its spread.MethodsWe interviewed patients with the respiratory symptoms by questionnaire. Respiratory samples were screened for six respiratory pathogens by real-time quantitative polymerase chain reaction (RT-PCR). The confirmed cases were further sequenced of G gene to confirm the HRSV genotype. A phylogenetic tree was reconstructed by maximum likelihood method.ResultsOf the 103 children in the kindergarten, 45 were classified as suspected cases, and 25 cases were confirmed by RT-PCR. All confirmed cases were identified from half of classes. 36% (9/25) were admitted to hospital, none died. The attack rate was 53.19%. The median ages of suspected and confirmed cases were 32.7 months and 35.8 months, respectively. Nine of 27 confirmed cases lived in one community. Only two-family clusters among 88 household contacts were HRSV positive. A total of 18 of the G gene were obtained from the confirmed cases. Phylogenetic analyses revealed that 16 of the sequences belonged to the HRSV B/BA9 genotype, and the other 2 sequences belonged to the HRSV A/ON1 genotype. The school were closed on June 9 and the outbreak ended on June 15.ConclusionThese findings suggest the need for an increased awareness of HRSV coinfections outbreak in the kindergarten, when HRSV resurges in the community after COVID-19 pandemic

Extending MultiJava with generics

MultiJava is an extension of the Java Programming Language with open classes and symmetric multiple dispatch. This thesis extends MultiJava by adding support for parametric polymorphism, which allows the definition and implementation of generic abstractions. Multiple dispatch has limited interaction with generics due to the semantics of generics chosen for Java. The interesting problem is how to mix MultiJava's open classes feature with the new generic feature. This thesis explains extensions to MultiJava's Semantics and describes the implementation of generics as an extension to the MJC compiler.</p

Extending MultiJava with generics

MultiJava is an extension of the Java Programming Language with open classes and symmetric multiple dispatch. This thesis extends MultiJava by adding support for parametric polymorphism, which allows the definition and implementation of generic abstractions. Multiple dispatch has limited interaction with generics due to the semantics of generics chosen for Java. The interesting problem is how to mix MultiJava\u27s open classes feature with the new generic feature. This thesis explains extensions to MultiJava\u27s Semantics and describes the implementation of generics as an extension to the MJC compiler

In-Depth Analysis of Railway and Company Evolution of Yangtze River Delta with Deep Learning

The coordinated development of smart cities has become the goal of world urban development, and the railway network plays an important role in this progress. This paper proposes a solution that integrates data acquisition, storage, GIS visualization, deep learning, and statistical correlation analysis to deeply analyze the distribution data of companies collected in the past 40 years in the Yangtze River Delta. Through deep learning, we predict the spatial distribution of the company after the opening of the train stations. Through statistical and correlation analysis of the company’s registered capital and quantity, the urban development relationship under the influence of the opening of the railway is explored. Going forward, the use and application of such analysis can be tested for use and application in the context of other smart cities for specific aspects or scale

Research on the Key Restrictive Factors of Green Energy Industry Development in Western China

The development of the green energy industry in western China plays an important role in promoting local economic and social development and ensuring national energy security. At the same time, industrial development also faces imbalances in the supply and demand of green energy, insufficient local energy consumption, limited extension of the industrial chain, poverty alleviation and ecological protection and other issues. Combining the development characteristics of the green energy industry in the western region, with policy guidance, market improvement, and technological progress as the main analysis framework, based on the Delphi method, the key constraints for the green energy industry in western China are proposed, and the western green energy industry and social economy. The possible mechanism of action between development has certain reference value for promoting the development of the green energy industry and improving the operation mechanism of the green energy industry