Collaborative Camouflaged Object Detection: A Large-Scale Dataset and Benchmark

In this paper, we provide a comprehensive study on a new task called collaborative camouflaged object detection (CoCOD), which aims to simultaneously detect camouflaged objects with the same properties from a group of relevant images. To this end, we meticulously construct the first large-scale dataset, termed CoCOD8K, which consists of 8,528 high-quality and elaborately selected images with object mask annotations, covering 5 superclasses and 70 subclasses. The dataset spans a wide range of natural and artificial camouflage scenes with diverse object appearances and backgrounds, making it a very challenging dataset for CoCOD. Besides, we propose the first baseline model for CoCOD, named bilateral-branch network (BBNet), which explores and aggregates co-camouflaged cues within a single image and between images within a group, respectively, for accurate camouflaged object detection in given images. This is implemented by an inter-image collaborative feature exploration (CFE) module, an intra-image object feature search (OFS) module, and a local-global refinement (LGR) module. We benchmark 18 state-of-the-art models, including 12 COD algorithms and 6 CoSOD algorithms, on the proposed CoCOD8K dataset under 5 widely used evaluation metrics. Extensive experiments demonstrate the effectiveness of the proposed method and the significantly superior performance compared to other competitors. We hope that our proposed dataset and model will boost growth in the COD community. The dataset, model, and results will be available at: https://github.com/zc199823/BBNet--CoCOD.Comment: Accepted by IEEE Transactions on Neural Networks and Learning Systems (TNNLS

Small genomic insertions form enhancers that misregulate oncogenes

The non-coding regions of tumour cell genomes harbour a considerable fraction of total DNA sequence variation, but the functional contribution of these variants to tumorigenesis is ill-defined. Among these non-coding variants, somatic insertions are among the least well characterized due to challenges with interpreting short-read DNA sequences. Here, using a combination of Chip-seq to enrich enhancer DNA and a computational approach with multiple DNA alignment procedures, we identify enhancer-associated small insertion variants. Among the 102 tumour cell genomes we analyse, small insertions are frequently observed in enhancer DNA sequences near known oncogenes. Further study of one insertion, somatically acquired in primary leukaemia tumour genomes, reveals that it nucleates formation of an active enhancer that drives expression of the LMO2 oncogene. The approach described here to identify enhancer-associated small insertion variants provides a foundation for further study of these abnormalities across human cancers

Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas

Of nine ependymoma molecular groups detected by DNA methylation profiling, the posterior fossa type A (PFA) is most prevalent. We used DNA methylation profiling to look for further molecular heterogeneity among 675 PFA ependymomas. Two major subgroups, PFA-1 and PFA-2, and nine minor subtypes were discovered. Transcriptome profiling suggested a distinct histogenesis for PFA-1 and PFA-2, but their clinical parameters were similar. In contrast, PFA subtypes differed with respect to age at diagnosis, gender ratio, outcome, and frequencies of genetic alterations. One subtype, PFA-1c, was enriched for 1q gain and had a relatively poor outcome, while patients with PFA-2c ependymomas showed an overall survival at 5 years of > 90%. Unlike other ependymomas, PFA-2c tumors express high levels of OTX2, a potential biomarker for this ependymoma subtype with a good prognosis. We also discovered recurrent mutations among PFA ependymomas. H3 K27M mutations were present in 4.2%, occurring only in PFA-1 tumors, and missense mutations in an uncharacterized gene, CXorf67, were found in 9.4% of PFA ependymomas, but not in other groups. We detected high levels of wildtype or mutant CXorf67 expression in all PFA subtypes except PFA-1f, which is enriched for H3 K27M mutations. PFA ependymomas are characterized by lack of H3 K27 trimethylation (H3 K27-me3), and we tested the hypothesis that CXorf67 binds to PRC2 and can modulate levels of H3 K27-me3. Immunoprecipitation/mass spectrometry detected EZH2, SUZ12, and EED, core components of the PRC2 complex, bound to CXorf67 in the Daoy cell line, which shows high levels of CXorf67 and no expression of H3 K27-me3. Enforced reduction of CXorf67 in Daoy cells restored H3 K27-me3 levels, while enforced expression of CXorf67 in HEK293T and neural stem cells reduced H3 K27-me3 levels. Our data suggest that heterogeneity among PFA ependymomas could have clinicopathologic utility and that CXorf67 may have a functional role in these tumors

3D Surface velocity retrieval of mountain glacier using an offset tracking technique applied to ascending and descending SAR constellation data: a case study of the Yiga Glacier

COSMO-SkyMed is a constellation of four X-band high-resolution radar satellites with a minimum revisit period of 12 hours. These satellites can obtain ascending and descending synthetic aperture radar (SAR) images with very similar periods for use in the three-dimensional (3D) inversion of glacier velocities. In this paper, based on ascending and descending COSMO-SkyMed data acquired at nearly the same time, the surface velocity of the Yiga Glacier, located in the Jiali County, Tibet, China, is estimated in four directions using an offset tracking technique during the periods of 16 January to 3 February 2017 and 1 February to 19 February 2017. Through the geometrical relationships between the measurements and the SAR images, the least square method is used to retrieve the 3D components of the glacier surface velocity in the eastward, northward and upward directions. The results show that applying the offset tracking technique to COSMO-SkyMed images can be used to derive the true 3D velocity of a glacier’s surface. During the two periods, the Yiga Glacier had a stable velocity, and the maximum surface velocity, 2.4 m/d, was observed in the middle portion of the glacier, which corresponds to the location of the steepest slope