Fast calibration of a projection-type holographic light-field display using hierarchically upconverted binary sinusoidal patterns

Captured images in iterative sinusoidal-pattern projections for distortion measurement

Visualization 1: Fast method of calculating a photorealistic hologram based on orthographic ray–wavefront conversion

Optically reconstructed 3D image Originally published in Optics Letters on 01 April 2016 (ol-41-7-1396

Super-resolution human-silhouette imaging by joint optimization of coded illumination and reconstruction network

In surveillance camera systems and other human-image analysis systems, it is important to measure human shapes with high resolution. However, the performance achievable through approaches based solely on optical design and image processing has limitations. To overcome these limitations, we propose a super-resolution imaging system for human silhouettes based on a jointly-optimized design involving coded illumination and a reconstruction network. Our proposed method allows for the acquisition of human silhouette data with improved sampling resolution without modifying the camera hardware. We quantitatively demonstrated the effectiveness of our proposed method through simulations and also through optical experiments using a projector and a camera

Visualization 1

Reconstructed 3D imag

Indole Synthesis via Cyclative Formation of 2,3-Dizincioindoles and Regioselective Electrophilic Trapping

Upon zincation of two acidic protons attached to the nitrogen and the sp-carbon atoms, a <i>N-</i>protected 2-ethynylaniline cyclizes to a 2,3-dizincioindole at 120 °C. Driven by the energy gain due to formation of two C–Zn bonds, this reaction occurs smoothly without side reactions, although this transformation is intrinsically endothermic in its bare anionic form. The resulting dizinc intermediate can be functionalized with one or two different electrophiles either inter- or intramolecularly on either C² or C³ selectively, depending on the choice of catalyst and the electrophiles. This conversion of 2-ethynylaniline to 2,3-dimetalloindole can be applied to an expeditious synthesis of indenoindolone and benzodipyrrole derivatives, which are compounds of interest for medicinal chemistry and materials science, respectively

Multi-layer lensless camera for improving the condition number

Computational lensless imaging is a technology that realizes the thinning of the optical system by replacing optical imaging with image reconstruction processing. While the conventional optical design used a single coded mask and an image sensor, recent studies have proposed optical designs that use multiple stacked coded apertures for multidimensional imaging and wide-field imaging. In this study, we investigate the effect of the multi-layering of the coded aperture on the performance of two-dimensional spatial imaging. We demonstrate through simulations and optical experiments that the multi-layering of the coded aperture improves the condition number of the transmission matrix of the optical system, and as a result, improves the accuracy of image reconstruction in lensless imaging

Relationships among Parvalbumin-Immunoreactive Neuron Density, Phase-Locked Gamma Oscillations, and Autistic/Schizophrenic Symptoms in PDGFR-β Knock-Out and Control Mice

<div><p>Cognitive deficits and negative symptoms are important therapeutic targets for schizophrenia and autism disorders. Although reduction of phase-locked gamma oscillation has been suggested to be a result of reduced parvalbumin-immunoreactive (putatively, GABAergic) neurons, no direct correlations between these have been established in these disorders. In the present study, we investigated such relationships during pharmacological treatment with a newly synthesized drug, T-817MA, which displays neuroprotective and neurotrophic effects. In this study, we used platelet-derived growth factor receptor-β gene knockout (PDGFR-β KO) mice as an animal model of schizophrenia and autism. These mutant mice display a reduction in social behaviors; deficits in prepulse inhibition (PPI); reduced levels of parvalbumin-immunoreactive neurons in the medical prefrontal cortex, hippocampus, amygdala, and superior colliculus; and a deficit in of auditory phase-locked gamma oscillations. We found that oral administration of T-817MA ameliorated all these symptoms in the PDGFR-β KO mice. Furthermore, phase-locked gamma oscillations were significantly correlated with the density of parvalbumin-immunoreactive neurons, which was, in turn, correlated with PPI and behavioral parameters. These findings suggest that recovery of parvalbumin-immunoreactive neurons by pharmacological intervention relieved the reduction of phase-locked gamma oscillations and, consequently, ameliorated PPI and social behavioral deficits. Thus, our findings suggest that phase-locked gamma oscillations could be a useful physiological biomarker for abnormality of parvalbumin-immunoreactive neurons that may induce cognitive deficits and negative symptoms of schizophrenia and autism, as well as of effective pharmacological interventions in both humans and experimental animals.</p></div

T-817MA ameliorated the decrease in density of parvalbumin-immunoreactive neurons in the mPFC (A), hippocampus (B), basolateral amygdala (BLA) (C), and superior colliculus (SC) (D) of PDGFR-β KO mice.

<p>**, p<0.01 (main effect of genotype); #, p<0.05 (main effect of treatment); a, significant difference between Cont-DW and KO-T817 in the BLA (Bonferroni test, p<0.01); b, significant difference between Cont-DW (Bonferroni test, p<0.01) and KO-T817 (Bonferroni test, p<0.05) in the SC.</p

T-817MA ameliorated PPI deficits in PDGFR-β KO mice.

<p>(A) Acoustic startle amplitudes measured in trials without a prepulse. No significant differences were observed in the acoustic startle amplitudes among the four groups of mice. Values indicate the mean ± SE. (B) PPI (% inhibition) at five different prepulse intensities (70, 72, 74, 78, and 82 dB). Statistical results by three-way ANOVAs indicated significant main effects of genotype and treatment. Cont-DW, control mice with distilled water (DW); Cont-T817, control mice with T-817MA; KO-DW, PDGFR-β KO mice with DW; KO-T817, PDGFR-β KO mice with T-817MA.</p

Comparison of peak-ITC (30.4–67.1 Hz) among the four groups.

<p>Peak-ITC was significantly lower in PDGFR-β KO mice administered with distilled water (KO-DW) compared to control mice administered with distilled water (Cont-DW) and PDGFR-β KO mice administered with T-817MA (KO-T817). aa, p<0.01 (Bonferroni test).</p