カネコ チクスイ ニ オケル ロマンテキ セイシン テンサイ ヘ ノジョウケイ トウコクシュウ ヲ ヨミテ シサイロン ヲ チュウシン ニ

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Outer Membrane Vesicles of Helicobacter pylori TK1402 are Involved in Biofilm Formation

<p>Abstract</p> <p>Background</p> <p><it>Helicobacter pylori </it>forms biofilms on glass surfaces at the air-liquid interface in <it>in vitro </it>batch cultures; however, biofilms of <it>H. pylori </it>have not been well characterized. In the present study, we analyzed the ability of <it>H. pylori </it>strains to form biofilms and characterized the underlying mechanisms of <it>H. pylori </it>biofilm formation.</p> <p>Results</p> <p>Strain TK1402 showed strong biofilm forming ability relative to the other strains in Brucella broth supplemented with 7% FCS. The strong biofilm forming ability of TK1402 is reflected the relative thickness of the biofilms. In addition, outer membrane vesicles (OMV) were detected within the matrix of only the TK1402 biofilms. Biofilm formation was strongly correlated with the production of OMV in this strain. We further observed that strain TK1402 did not form thick biofilms in Brucella broth supplemented with 0.2% β-cyclodextrin. However, the addition of the OMV-fraction collected from TK1402 could enhance biofilm formation.</p> <p>Conclusion</p> <p>The results suggested that OMV produced from TK1402 play an important role in biofilm formation in strain TK1402.</p

Concert recording 2017-12-06

[Track 1]. Allegro barbaro, BB63 / Béla Bartok -- [Track 2]. Etude in A♭ major, op. 25, no. 1 / Frédéric Chopin -- [Track 3]. Solo de concours, op. 10 / Henri Rabaud -- [Track 4]. Concerto no. 2 in F minor, op. 5. III. Rondo: Allegretto / Bernard Crusell -- [Track 5]. Premiere rhapsodie / Claude Debussy -- [Track 6]. Solo de concours, op. 10 / Henri Rabaud -- [Track 6]. Sonata for clarinet and piano. IV. Mässig bewegt / Paul Hindemith -- [Track 7]. Sonata for trumpet in B♭ major / Paul Hindemit

Nurses' Practical Wisdom for the Support of Dementia Patients Among Hospital Outpatients

Purpose: To establish and understand nurses' practical wisdom and interventions of support for dementia and possible dementia patients at hospital outpatient wards. Methods: A qualitative design was used to collect data through semi-structured focus group interviews. The participants were 13 female nurses working at hospital outpatient wards.Data were analyzed using the KJ Method. Results: Seven themes symbolizing the properties of the final label were extracted as follows:‘Observation of patients with focused awareness, and are continuously engaged with their patients',‘Approach to the problems of the patients, and sensitively work to understand the worries of patients based on past cases of problems',‘Looking out for simple ways patients can look after themselves, implicitly and thoroughly, making the best use of the ways that patients are familiar with and which they are able to understand',‘Preparations for scheduled consultations by developing a network to assist with problem prevention and recording episodes about problems involving the patients',‘Requests for cooperation to continue treatment by choosing intermediaries/resources appropriately as based on the importance of the medical treatment',‘Responses that do not conflict with the feelings of the family by considering the possible reluctance of accepting that a family member has dementia', and‘Attitude not to blame matters on dementia by reflecting on how the environment and care ought to be'.’ Conclusion:Nurses' practical wisdom is a type of support provided for patients in a natural manner without being noticed as special or particular by the patients

Concert recording 2017-04-23a

[Track 1]. From Rêverie. Sognai / Francesco Schira -- [Track 2]. Êtude-Tableau op. 39, no. 5 / Sergi Rachmaninoff -- [Track 3]. Capriccio / Rodney Newton -- [Track 4]. Solo de pajarillo / Omar Acosta -- [Track 5]. Butterflies and bobcats / David L. McIntyre -- [Track 6]. Song to the mother / Johannes Möller -- [Track 7]. Concerto for bass trombone. III. James Brown in the twilight zone / Chris Brubeck

Brief Questioning by Nursing Staffs before Endoscopic Examination May Not Always Pick Up Clinical Symptoms of Endoscopic Reflux Esophagitis

The clinical features of patients reflux esophagitis without any symptoms have not been clearly demonstrated. This study evaluated the clinical features of patients with endoscopy-positive reflux esophagitis, who did not complain of symptoms, as detected by brief questioning by nursing staffs. Eight thousand and thirty-one patients not taking medication for gastrointestinal disease, were briefly asked about the presence of heartburn, dysphagia, odynophagia and acid regurgitation by nursing staffs before endoscopy for assessment of esophagitis utilizing the Los Angeles Classification. Endoscopically, 1199 (14.9%) patients were classified as positive for reflux esophagitis. The endoscope positive subjects who complain heartburn were 539/1199 (45.0%).The endoscope positive subjects who do not complain symptoms were 465 in 1199 positive reflux esophagitis (38.8%). We compared endoscopic positive subjects without any complain by brief question by nursing staffs to endoscopic positive subjects with heartburn. Male gender, no obesity, absence of hiatus hernia, and low-grade esophagitis were associated with endoscopy-positive patients who do not complain of symptoms. The results of this study indicated correct detection of clinical symptoms of reflux esophagitis might be not easy with brief questioning by nursing staffs before endoscopic examination

Potential of cowpea (Vigna unguiculata L.) meal as an alternative protein source in diets for giant freshwater prawn (Macrobrachium rosenbergii, de Man 1879)

Growth trials were conducted to evaluate cowpea Vigna unguiculata (L.) meal as a potential protein source in diets for giant freshwater prawn, Macrobrachium rosenbergii (de Man 1879), reared in tank and lake-based cages. Five isonitrogenous (approximately 37% crude protein) and isocaloric diets were formulated where fish meal (FM) protein was replaced with 0%, 15%, 30%, 45% and 60% cowpea meal protein (or CP0, CP15, CP30, CP45, and CP60, respectively). Results of an 8-week tank trial showed that the final body weight (FBW), percent weight gain, specific growth rate (SGR) and survival of prawns were not significantly influenced by dietary treatments (P > 0.05), although the highest values, except for survival, were observed with CP45. In a lakebased cage trial that lasted for 16 weeks, prawns fed CP30 and CP45 had significantly higher FBW (13.1 and 14.4 g, respectively) compared to other treatment groups (P < 0.05). SGR (4.52 5.00%/ day), survival rates (53-77%), yield (98.5-116.5 g m-2) and feed conversion ratio (FCR; 2.0-2.7) were not affected by increasing levels of cowpea meal in the diets. Based on these results, cowpea meal can be considered as an alternative protein source in diets for M. rosenbergii

Retinol Supplements Antiviral Action of Interferon in Patients with Chronic Hepatitis C: A Prospective Pilot Study

Sustained virologic response with peg-interferon and ribavirin combination therapy for 48 weeks is still inadequate. Our study examined whether short-term administration of retinol clinically influences the anti-viral activity of interferon early during interferon and ribavirin combination therapy. The control group received 6 MIU of interferon α-2b every day for two weeks and then 3 times a week for 22 weeks intramuscularly plus 600 mg or 800 mg per day of ribavirin orally for 24 weeks. The retinol group, in addition to above treatment, received retinol 30,000 units per day orally for 3 weeks from one week before the start of interferon α-2b plus ribavirin combination therapy. The hepatitis C virus (HCV) RNA negativity rate at 1 week after the end of interferon α-2b and ribavirin combination therapy was 46.7% (28/60) for the retinol group and 31.7% (19/60) for the control group, which was significantly higher for the retinol group. The level of serum HCV RNA in the retinol group was significantly lower at 1 week after beginning treatment as compared to the control group (p<0.01). Furthermore, serum 2,5'AS protein at 1 week after beginning treatment was significantly higher in the retinol group (p = 0.0002). The results suggest that retinol supplement increases the antiviral effect of interferon α-2b plus ribavirin only during the administration of IFN α-2b, ribavirin and retinol in patients with chronic hepatitis C