Investigation of the rotation effects on high--density matter in hybrid stars

The equation of state (EOS) of high-density matter is still not clear and several recent observations indicate restrictions to EOSs. Theoretical studies should thus elucidate EOSs at high density and/or high temperature. Many theoretical studies have attempted to account for the effect of rotation of rapidly rotating neutron stars (pulsars), which are commonly observed astronomical objects having high-density interiors. Furthermore, neutron stars generate a strong magnetic field. Several recent studies indicate that this magnetic field exerts some restrictions on the EOS. Theoretical studies should thus incorporate these effects. In this paper, we focus on the effect of rotation. We find that one of our EOSs is consistent with these observations, and another is inconsistent. We also find an important relation between radius and rotation.Comment: 4 pages, 2 figures, proceeding of PANIC201

Numerical study of the hadron-quark mixed phase

The Coulomb screening effect and the finite-size effect such as surface tension are figured out in the hadron-quark deconfinement phase transition. We study the mixed phase of the quark droplets immersed in hadron matter. We see that the droplet phase is mechanically unstable if the surface tension is strong enough. Once the Coulomb potential is properly taken into account, we could effectively satisfy the condition for charge chemical equilibrium in the Maxwell construction. As a result, we suggest the Maxwell construction revives the physical meaning effectively.Comment: 4 pages, 4figures, proceeding of Phase Transitions in Strongly Interacting Matter 18th International Nuclear Physics Divisional Conference of the EPS (NPDC18)Europhysics Conferenc

Region of hadron-quark mixed phase in hybrid stars

Hadron--quark mixed phase is expected in a wide region of the inner structure of hybrid stars. However, we show that the hadron--quark mixed phase should be restricted to a narrower region to because of the charge screening effect. The narrow region of the mixed phase seems to explain physical phenomena of neutron stars such as the strong magnetic field and glitch phenomena, and it would give a new cooling curve for the neutron star.Comment: to be published in Physical Review

Tunable tunnel coupling in a double quantum antidot with cotunneling via localized state

Controlling tunnel coupling between quantum antidots (QADs) in the quantum Hall (QH) regime is problematic. We propose and demonstrate a scheme for tunable tunnel coupling between two QADs by utilizing a cotunneling process via a localized state as a third QAD. The effective tunnel coupling can be tuned by changing the localized level even with constant nearest-neighbor tunnel couplings. We systematically study the variation of transport characteristics in the effectively triple QAD system at the Landau level filling factor $\nu =2$. The tunable tunnel coupling is clarified by analyzing the anti-crossing of Coulomb blockade peaks in the charge stability diagram, in agreement with numerical simulations based on the master equation. The scheme is attractive for studying coherence and interaction in QH systems.Comment: 11 pages, 8 figure

Finite size effects on kaonic pasta structures

Non-uniform structures of mixed phases at the first-order phase transition to charged kaon condensation are studied using a density functional theory within the relativistic mean field model. Including electric field effects and applying the Gibbs conditions in a proper way, we numerically determine density profiles of nucleons, electrons and condensed kaons. Importance of charge screening effects is elucidated and thereby we show that the Maxwell construction is effectively justified. Surface effect is also studied to figure out its effect on the density profiles

館山湾坂田におけるベラ科オハグロベラの産卵期と非産卵期における生息場所

千葉県館山市坂田海岸においてベラ科オハグロベラの産卵期と非産卵期における雌雄の生息場所を観察した．本種の産卵期は6月から8月までである．産卵期(6月 ～ 8月）および非産卵期（5月，9月 ～ 12月）の各月に，産卵場から岸に向かって100 mのラインを引き, そのライン上を20 mごとに区切った1から6の地点を調査地点における雌雄の個体数を調査した．産卵期は雌雄共に産卵場付近に個体数が多かった．非産卵期になると雌は岸寄りに移動したが，雄は出現場所に偏りが無かった．出現個体数は，雌では産卵期・非産卵期共に差はなかったが，雄では非産卵期になると減少したHabitat of the wrasse Pteragogus aurigarius was studied in both spawning and non-spawning seasons at Banda Beach, Tateyama, Japan. Spawning season of this species is from June to August. Once a month in spawning (June to August) and non-spawning (May, September to December) seasons, we counted number of female and male individuals in six points by 20 m interval along the 100 m line set on the bottom from the spawning site to seashore. Both female and male were abundant near the spawning site in the spawning season. In the non-spawning season, number of female individuals increased near seashore, while the males evenly distributed. Although there was no significant difference in number of female individuals between spawning and non-spawning seasons, those of the males had decreased in non-spawning season.Shuta ENDO(Corresponding author), Sayo TOMATSU and Tomoki SUNOBE: Laboratory of Fish Behavioral Ecology, Tateyama Station, Field Science Center, Tokyo University of Marine Science and Technology (TUMSAT)遠藤 周太・戸松 紗代・須之部 友基: 東京海洋大学館山ステーション魚類行動生態学研究室Shuta ENDO: Tokyo Sea Life Park遠藤 周太: 葛西臨海水族

Methotrexate Alters the Expression of microRNA in Fibroblast-like Synovial Cells in Rheumatoid Arthritis

We aimed to investigate the effect of methotrexate (MTX) on microRNA modulation in rheumatoid arthritis fibroblast-like synovial cells (RA-FLS). RA-FLS were treated with MTX for 48 h. We then performed miRNA array analysis to investigate differentially expressed miRNAs. Transfection with miR-877-3p precursor and inhibitor were used to investigate the functional role of miR-877-3p in RA-FLS. Gene ontology analysis was used to investigate the cellular processes involving miR-877-3p. The production of cytokines/chemokines was screened by multiplex cytokine/chemokine bead assay and confirmed by ELISA and quantitative real-time PCR. The migratory and proliferative activities of RA-FLS were analyzed by wound healing assay and MKI-67 expression. MTX treatment altered the expression of 13 miRNAs (seven were upregulated and six were downregulated). Among them, quantitative real-time PCR confirmed that miR-877-3p was upregulated in response to MTX (1.79 ± 0.46-fold, p < 0.05). The possible target genes of miR-877-3p in RA-FLS revealed by the microarray analysis were correlated with biological processes. The overexpression of miR-877-3p decreased the production of GM-CSF and CCL3, and the overexpression of miR-877-3p inhibited migratory and proliferative activity. MTX altered the miR-877-3p expression on RA-FLS, and this alteration of miR-877-3p attenuated the abundant production of cytokines/chemokines and proliferative property of RA-FLS

Reactive arthritis induced by active extra-articular tuberculosis

RATIONALE: Rare cases of reactive arthritis induced by active extra-articular tuberculosis (Poncet disease) have been reported. Complete response to antitubercular treatment and evidence of active extra-articular tuberculosis are the most important clinical features of Poncet disease. We report the case of successfully treated a patient with reactive arthritis induced by active extra-articular tuberculosis with a TNF inhibitor after sufficient antitubercular treatment. PATIENT CONCERNS: A 56-year-old Japanese man was admitted to our department with polyarthralgia, low back pain, and high fever. The results of rheumatoid factor, anti-citrullinated protein antibody, human leukocyte antigen B27, and the assays for the detection of infections (with an exception of T-SPOT.TB) were all negative. Fluoro-deoxy-D-glucose-positron emission tomography with CT (PET/CT) showed moderate uptake in the right cervical, right supraclavicular, mediastinal, and abdominal lymph nodes. As magnetic resonance imaging and power Doppler ultrasonography showed peripheral inflammation (tendinitis, tenosynovitis, ligamentitis, and enthesitis in the limbs). DIAGNOSIS: A diagnosis of tuberculous lymphadenitis was eventually established on the basis of lymph node biopsy results. There was no evidence of a bacterial infection including acid-fast bacteria in his joints, and the symptoms of polyarthralgia and low back pain were improved but not completely resolved with NSAID therapy; in addition, a diagnosis of reactive arthritis induced by active extraarticular tuberculosis was made. INTERVENTIONS: The patient experienced persistent peripheral inflammation despite antitubercular treatment for more than nine months and was then successfully treated with a tumor necrosis factor inhibitor (adalimumab 40 mg every 2 weeks). OUTCOMES: Finally, the patient responded to the treatment and has been in remission for over 4 months as of this writing. LESSONS: In patients who present with symptoms associated with spondyloarthritis, it is important to distinguish between classic reactive arthritis and reactive arthritis induced by extra-articular tuberculosis infection. Introduction of biological agents should be carefully considered in settings where reactive arthritis induced by active extra-articular tuberculosis shows progression to chronicity despite sufficient antitubercular treatment