Development and External Validation of a Nomogram Predicting the Probability of Significant Gleason Sum Upgrading among Japanese Patients with Localized Prostate Cancer

Objective. The aim of this study is to develop a prognostic model capable of predicting the probability of significant upgrading among Japanese patients. Methods. The study cohort comprised 508 men treated with RP, with available prostate-specific antigen levels, biopsy, and RP Gleason sum values. Clinical and pathological data from 258 patients were obtained from another Japanese institution for validation. Results. Significant Gleason sum upgrading was recorded in 92 patients (18.1%) at RP. The accuracy of the nomogram predicting the probability of significant Gleason sum upgrading between biopsy and RP specimens was 88.9%. Overall AUC was 0.872 when applied to the validation data set. Nomogram predictions of significant upgrading were within 7.5% of an ideal nomogram. Conclusions. Nearly one-fifth of Japanese patients with prostate cancer will be significantly upgraded. Our nomogram seems to provide considerably accurate predictions regardless of minor variations in pathological assessment when applied to Japanese patient populations

First EMC3-EIRENE Simulations with Divertor Legs of LHD in Realistic Device Geometry

An extended mesh system for EMC3-EIRENE has been developed to simulate peripheral plasma including the ergodic and the divertor leg regions of LHD. Both the open and the closed divertor configurations are available. A series of simulations for 8MW input power, five different electron densities at the LCFS (last closed flux surface) and the open/closed configurations were carried out. Approximately 10 times larger neutral pressure was observed under the dome structure compared with the open configuration, which is in good agreement with experimental measurements. In the case of the closed configuration, the leg regions have a large contribution of ionization to hydrogen recycling. In the case of high density discharges, however, electron temperature in the legs becomes low and the major contribution of ionization moves to the ergodic region. Significant influence of configurations is observed in the inboard side of LHD, where closed divertor components are installed but little influence is seen near the LCFS. (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Distinct Clinic-Pathological Features of Early Differentiated-Type Gastric Cancers after Helicobacter pylori

Background. Gastric cancer is discovered even after successful eradication of H. pylori. We investigated clinic pathological features of early gastric cancers after H. pylori eradication. Methods. 51 early gastric cancers (EGCs) from 44 patients diagnosed after successful H. pylori eradication were included as eradication group. The clinic-pathological features were compared with that of 131 EGCs from 120 patients who did not have a history of H. pylori eradication (control group). Results. Compared with control group, clinic-pathological features of eradication group were characterized as depressed (p<0.0001), reddish (p=0.0001), and smaller (p=0.0095) lesions, which was also confirmed in the comparison of six metachronous lesions diagnosed after initial ESD and subsequent successful H. pylori eradication. Prevalence of both SM2 (submucosal invasion greater than 500 μm) and unexpected SM2 cases tended to be higher in eradication group (p=0.077, 0.0867, resp.). Prevalence of inconclusive diagnosis of gastric cancer during pretreatment biopsy was also higher in the same group (26.0% versus 1.6%, p<0.0001). Conclusions. Informative clinic pathological features of EGC after H. pylori eradication are depressed, reddish appearances, which should be treated as a caution because histological diagnosis of cancerous tissue is sometimes difficult by endoscopic biopsy

An association between systolic blood pressure and stroke among patients with impaired consciousness in out-of-hospital emergency settings

Background: Stroke is difficult to diagnose when consciousness is disturbed. However few reports have discussed the clinical predictors of stroke in out-of-hospital emergency settings. This study aims to evaluate the association between initial systolic blood pressure (SBP) value measured by emergency medical service (EMS) and diagnosis of stroke among impaired consciousness patients. Methods: We included all patients aged 18 years or older who were treated and transported by EMS, and had impaired consciousness (Japan Coma Scale ≧ 1) in Osaka City (2.7 million), Japan from January 1, 1998 through December 31, 2007. Data were prospectively collected by EMS personnel using a study-specific case report form. Multiple logistic regressions assessed the relationship between initial SBP and stroke and its subtypes adjusted for possible confounding factors. Results: During these 10 years, a total of 1,840,784 emergency patients who were treated and transported by EMS were documented during the study period in Osaka City. Out of 128,678 with impaired consciousness, 106,706 who had prehospital SBP measurements in the field were eligible for our analyses. The proportion of patients with severe impaired consciousness significantly increased from 14.5% in the =200 mmHg SBP group (P for trend =200 mmHg group versus the SBP 101-120 mmHg group was 5.26 (95% CI 4.93 to 5.60). The AOR of the SBP > =200 mmHg group versus the SBP 101-120 mmHg group was 9.76 in subarachnoid hemorrhage (SAH), 16.16 in intracranial hemorrhage (ICH), and 1.52 in ischemic stroke (IS), and the AOR of SAH and ICH was greater than that of IS. Conclusions: Elevated SBP among emergency patients with impaired consciousness in the field was associated with increased diagnosis of stroke

Experimental observations and modelling of radiation asymmetries during N2 seeding in LHD

N2 gas has been seeded in the Large Helical Device (LHD) to reduce the divertor heat load through enhanced radiation. Radiation is observed by two imaging bolometers, viewing the same poloidal cross-section from top and bottom ports, at a location which is 36° toroidally removed from the N2 gas puff nozzle located at the bottom of the machine. During N2 seeding, these measurements both confirm that additional radiation from the outboard side is coming exclusively from the top of the cross-section, indicating up/down asymmetry, which is also reproduced by modelling with EMC3-EIRENE using a half torus model. In addition, a toroidally localized, magnetic field direction-dependent radiation enhancement is observed with N2 seeding, but is not reproducible by the model

Distribution and seasonality of sessile organisms on settlement panels submerged in Otsuchi Bay

Diversity and seasonal changes of the sessile organism assemblage in Otsuchi Bay (from 2013 to 2014) were surveyed by using moored settlement panels. Two barnacle species Balanus trigonus and Megabalanus rosa were remarkably abundant in summer. The barnacles showed different distribution patterns with depth; M. rosa tends to be abundant in 5–10 m deep, while B. trigonus was particularly abundant in deeper depths. More than 15 genera of encrusting bryozoans were obtained in Otsuchi Bay. The diversity of bryozoan genera was highest in summer–autumn; especially abundant in the southern inner-part of the bay. Botryllid colonial ascidians were abundant in autumn and early spring; especially abundant in the southern and inner-part of the bay. Most sessile organisms tended to be abundant in the southern part of the bay, where the outflow of the water current in the bay containing river water strongly affected. In the early spring, macroalgae tended to be abundant and sessile organisms decreased. Colonial organisms such as hydroids, colonial ascidians and bryozoans are considered to be primary colonizers on new substrates in Otsuchi Bay. Subsequent complex structures on substrates constructed by secondary colonizers such as barnacles and mussels provided the habitats for other organisms.Special Issue（東日本大震災特集

Redescription of Alox chaunos Galil & Ng, 2007 (Crustacea: Decapoda: Brachyura: Leucosiidae) new to Japan; with notes on the male characters of A. latusoides (Sakai, 1937)

Ohtsuchi, Naoya, Kawamura, Tomohiko (2016): Redescription of Alox chaunos Galil & Ng, 2007 (Crustacea: Decapoda: Brachyura: Leucosiidae) new to Japan; with notes on the male characters of A. latusoides (Sakai, 1937). Zootaxa 4111 (1): 41-52, DOI: http://doi.org/10.11646/zootaxa.4111.1.