2,605 research outputs found
Use of phytotherapics in dogs and cats.
Phytotherapy is one of the most utilized non conventional medicines (NCM) both in human and veterinary medicine. It can be used to mitigate and prevent slight diseases and to support conventional medicine using allopathic drugs. In this paper the Authors report the phytoterapeutics most utilized in both dogs and cats, in which the use of phytotherapics is increasing, despite the prejudices of the academic world and of the veterinary practitioners. Laws regarding the use of non conventional medicines in veterinary practises are lacking in Italy, despite many other countries in Europe; yet National Federation of Italian Veterinaries (F.N.O.V.I.) asserted that the use of NCM has to be considered a veterinary practise at all. At the end of this paper, the Authors provided many examples of phytotheapic prescriptions to control different illness in both dogs and cats
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High-J CO line emission from young stellar objects: from ISO to FIRST
we present the CO pure rotational spectrum at high J (Jup14) obtained with the Long Wavelength Spectrometer (LWS) on board of the ISO satellite towards molecular outflows exciting sources in nearby star formation regions. The physical conditions, derived using an LVG model for the line emission, indicate the presence of warm and dense gas, probably shock excited. The model fits show that often the bulk of this CO emission is expected in the spectral range that will be covered by FIRST, indicating the potentiality of this satellite to trace the warm component of gas emission in young stellar objects
What makes a workday meaningful? Evidence on the role of task significance, competence and subjective meaningful work
Purpose: The construct of meaningful work is a relevant topic for the managerial literature interested in job design, employeesâ motivation, and job performance. The current research seeks to improve our knowledge on meaningful work by exploring the processes by which a workday is experienced as meaningful. Design/methodology/approach: Adopting the lens of the Job Demands-Resources model and Self-Determination theory, we argue that work conditions and psychological conditions are associated with the experience of meaningful work on a daily basis. Moreover, we propose that the experience of meaningful work on a long-term basis (i.e. the evaluation of oneâs own work as holding significance per se) intensifies the associations between daily conditions and the experience of meaningful work. We collected data via an event-based longitudinal diary study for a total sample of NÂ =Â 114 employees from six organizations and NÂ =Â 545 observations. Findings: Results of the multilevel analysis showed that competence and task significance led to the experience of meaningful work during working days. Moreover, cross-level analyses revealed that these associations are stronger for employees who experience their work to be meaningful in the long-term. Originality/value: The novelty of the present study lies in highlighting the role of specific factors contributing to the experience of meaningful work during a workday. These findings help specify targets and organizational and individual dimensions to be addressed by managerial interventions to ensure employees' meaningful work experience
Intraoperative electrically auditory brainstem responses to monitor auditory functionality preservation during auditory brainstem implant application.
Background: Perceptual outcomes of individuals with neurofibromatosis type II implanted with auditory brainstem implant are poor, and many factors seem to be involved. Undoubtedly, the preservation of neural functionality is the crucial aspect. The aim of this study is to verify that the use of intraoperative electrically auditory brainstem responses can help to understand if there is neural damage related to the tumor, and / or surgery. Material and Methods: A retrospective case series analysis was performed to review data from 6 adult patients affected by neurofibromatosis type 2 who received an auditory brainstem implant. A correlation was sought between intraoperative electrophysiological data, auditory performance at 1 and 2.5 years of follow-up, and auditory brainstem implant stimulation levels. Results: Patients with a better perceptual outcomes were those with more intraoperative peaks and peaks with wider amplitudes in the electrically auditory brainstem response recordings. Conclusions: Electrically auditory brainstem responses used for auditory brainstem implant placement can be a valuable tool for monitoring the preservation of neural acoustic functionality
Metastatic melanoma cells with BRAF G469A mutation: nabâpaclitaxel better than vemurafenib?
Purpose BRAF G469A is a missense mutation within
exon 11 of the BRAF gene resulting in a constitutively
activated enzyme frequently associated with MAP kinase
cascade signaling activation. No evidence currently exists
about its role in determining sensitivity/resistance to BRAF
inhibitors, utilized in the treatment of patients carrying
BRAF V600 mutations, and to chemotherapy. The newly
established metastatic melanoma (MM) cell line MO-1 was
characterized for its sensitivity to vemurafenib and nabpaclitaxel, both already utilized for the treatment of MM.
Methods All analyses were carried out by comparing
results with those found in MM cells wild type for BRAF
or mutated in V600. In addition, cellular effectors were
investigated by ELISA kits, western blotting and flow
cytometry.
Results The exposure to vemurafenib inhibited MO-1 cell
proliferation at concentrations similar to those obtained in
vemurafenib-resistant melanoma models, and an explanation of this sensitivity is the strong activation of Erk1/2 .
and the low expression of MITF. Nab-paclitaxel strongly
reduced proliferation of MO-1 cells perhaps for the very
low expression level of PMEL17, transcriptionally regulated by MITF and negatively involved in determining sensitivity to taxanes.
Conclusions Thus, the mutation BRAF G469A in MM
might be related to a weak effectiveness of therapy with
BRAF inhibitors and a promising therapeutic approach
may be with nab-paclitaxel
Integrated biorefinery strategy for poly(3-hydroxybutyrate) accumulation in Cupriavidus necator DSM 545 using a sugar rich syrup from cereal waste and acetate from gas fermentation
Poly(3-hydroxybutyrate) (PHB) is one of the most well-known biodegradable and biocompatible biopolymers
produced by prokaryotic microorganisms. It belongs to the family of polyhydroxyalkanoates (PHAs), and it has
gained significant attention in recent years due to its potential as a sustainable alternative to traditional
petroleum-based plastics. Cupriavidus necator has been identified as a potential producer of PHB for industrial
applications due to its ability to produce high amounts of the polymer under controlled conditions, using a wide
range of waste substrates. In this study, the ability of Cupriavidus necator DSM 545 strain to produce PHB was
tested in a fed-batch strategy providing two different organic substrates. The first is a sugar-based syrup (SBS),
derived from cereal waste. The second is an acetate-rich medium obtained through CO2 -H2 fermentation by the
acetogenic bacterium Acetobacterium woodii. The carbon sources were tested to improve the accumulation of PHB
in the strain. C. necator DSM 545 proved to be able to grow and to perform high accumulation of biopolymer on
waste substrates containing glucose, fructose, and acetate, reaching about 10 g/L of PHB, 83% of biopolymer
accumulation in cell dry mass, in 48 h of fed-batch fermentation in 0.6 L working volume in a bioreactor.
Moreover, a Life Cycle Assessment analysis was performed to evaluate the environmental impact of the process
converting the sugar syrup alone and the integrated one. It demonstrated that the integrated process is more
sustainable and that the most impactful step is the PHB production, followed by the polymer extraction
Direct Measurement of the Reduced Scattering Coefficient by a Calibrated Random Laser Sensor
The research in optical sensors has been largely encouraged by the demand for low-cost and less or non-invasive new detection strategies. The invention of the random laser has opened a new frontier in optics, providing also the opportunity to explore new possibilities in the field of sensing, besides several different and peculiar phenomena. The main advantage in exploiting the physical principle of the random laser in optical sensors is due to the presence of the stimulated emission mechanism, which allows amplification and spectral modification of the signal. Here, we present a step forward in the exploitation of this optical phenomenon by a revisitation of a previous experimental setup, as well as the measurement method, in particular to mitigate the instability of the results due to shot-to-shot pump energy fluctuations. In particular, the main novelties of the setup are the use of optical fibers, a reference sensor, and a peristaltic pump. These improvements are devoted to: eliminating optical beam alignment issues; improving portability; mitigating the variation in pump energy and gain medium performances over time; realizing an easy and rapid change of the sensed medium. The results showed that such a setup can be considered a prototype for a portable device for directly measuring the scattering of liquid samples, without resorting to complicated numerical or analytic inversion procedures of the measured data, once the suitable calibration of the system is performed
COMPARATIVE ANALYSIS OF TECHNICAL, ECONOMICAL AND ENVIRONMENTAL FEASIBILITY OF COGENERATION PLANT USING WOOD BIOMASS
After having identified, in a previous work [6], the possible sites for the location of a new cogeneration plant using wood biomass in the Mountain Community of Carnia, Friuli Venezia Giulia Region (Italy), the technical and economic feasibility and environmental sustainability of such a system has been carried out in order to evaluate the feasibility of the proposed solution
OptEEmAL: Decision-Support Tool for the Design of Energy Retrofitting Projects at District Level
Designing energy retrofitting actions poses an elevated number of problems, as the definition of the baseline, selection of indicators to measure performance, modelling, setting objectives, etc. This is time-consuming and it can result in a number of inaccuracies, leading to inadequate decisions. While these problems are present at building level, they are multiplied at district level, where there are complex interactions to analyse, simulate and improve. OptEEmAL proposes a solution as a decision-support tool for the design of energy retrofitting projects at district level. Based on specific input data (IFC(s), CityGML, etc.), the platform will automatically simulate the baseline scenario and launch an optimisation process where a series of Energy Conservation Measures (ECMs) will be applied to this scenario. Its performance will be evaluated through a holistic set of indicators to obtain the best combination of ECMs that complies with user's objectives. A great reduction in time and higher accuracy in the models are experienced, since they are automatically created and checked. A subjective problem is transformed into a mathematical problem; it simplifies it and ensures a more robust decision-making. This paper will present a case where the platform has been tested.This research work has been partially funded by the European Commission though the European Unionâs Horizon 2020 Research and Innovation Programme under grant agreement No 680676. All related information to the project is available at https://www.opteemal-project.eu
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