2 research outputs found
Modular Flow-Through Platform for Spectroelectrochemical Analysis
A new
type of flow platform for electrochemical and spectroelectrochemical
measurements is presented. Finite element method simulations confirm
that the hydrodynamic profile within the device is not turbulent and
provides an analytical platform for the investigation of homogeneous
kinetics, radical lifetimes, and reaction mechanisms. The modular
âplug and playâ configuration of the platform allows
one to carry out electrochemistry and spectroscopy individually or
simultaneously. Specific demonstrations of electroanalytical measurements
using the flow system platform includes voltammetric analysis of organometallic
compounds and quantitative analysis of ascorbic acid in commercial
orange juice samples. Combined spectroelectrochemical demonstrations
include electrochemical luminescence of ruthenium compounds and ligand
exchange reactions of iron complexes using UVâvis spectroscopy
Ferrocene-Modified Phospholipid: An Innovative Precursor for Redox-Triggered Drug Delivery Vesicles Selective to Cancer Cells
Controlled payload release is one
of the key elements in the creation
of a reliable drug delivery system. We report the discovery of a drug
delivery vessel able to transport chemotherapeutic agents to target
cancer cells and selectively trigger their release using the electrochemical
activity of a ferrocene-modified phospholipid. Supported by <i>in vitro</i> assays, the competitive advantages of this discovery
are (i) the simple one step scalability of the synthetic process,
(ii) the stable encapsulation of toxic drugs (doxorubicin) during
transport, and (iii) the selective redox triggering of the liposomes
to harness their cytotoxic payload at the cancer site. Specifically,
the redox-modified giant unilamellar vesicle and liposomes were characterized
using advanced methods such as scanning electrochemical microscopy
(SECM), transmission electron microscopy (TEM), dynamic light scattering
(DLS), and fluorescent imaging