Differences between the risk of GD onset in young patients compared to older patients according to the coexistence of pairs of polymorphisms.

<p>OR: odds ratio; OR = 1.0 (ref.): referent category.</p

Results of the MDR analysis of the gene pair models differentiating the patient subgroups according to age at time of GD onset.

<p>Results of the MDR analysis of the gene pair models differentiating the patient subgroups according to age at time of GD onset.</p

General clinical characteristics of patients with GD included in this study.

<p>General clinical characteristics of patients with GD included in this study.</p

Frequency of the alleles and distribution of the genotypes of the four genes in patients with GD stratified by age at GD onset.

<p>Frequency of the alleles and distribution of the genotypes of the four genes in patients with GD stratified by age at GD onset.</p

Summary of the MDR results.

<p>Summary of the MDR results.</p

Odds ratio analysis of young patients compared to older patients with adjustment for smoking.

<p>Young/older: number of patients with age of onset of GD ≤ 30 years/number of patients with age of onset of GD > 30 years adjusted by smoking status; carriers: carriers of minor alleles.</p

Methods of genotyping of analyzed polymorphism.

<p>Methods of genotyping of analyzed polymorphism.</p

Allele frequency in patients with Graves' disease (GD)and control group.

*<p>with Bonferroni correction.</p

HLA-DRB1-03 genotypes in patients with Graves' disease (GD) stratified by the age at GD diagnosis.

<p>HLA-DRB1-03 genotypes in patients with Graves' disease (GD) stratified by the age at GD diagnosis.</p

Clinical characteristics of patients with GD, N = 768.

<p>Clinical characteristics of patients with GD, N = 768.</p