2 research outputs found
Coupling of SARS-CoV‑2 to Aβ Amyloid Fibrils
The COVID-19 infection
has been more problematic for individuals
with certain health predispositions. Coronaviruses could also interfere
with neural diseases if the viruses succeed in entering the brain.
Therefore, it might be of principal interest to examine a possible
coupling of coronaviruses and amyloid fibrils. Here, molecular dynamics
simulations were used to investigate direct coupling of SARS-CoV-2
and Aβ fibrils, which play a central role in neural diseases.
The simulations revealed several stable binding configurations and
their dynamics of Aβ42 fibrils attached to spike proteins of
the Omicron and Alpha variants of SARS-CoV-2