Surgical treatment of solitary adrenal metastasis from non-small cell lung cancer

Background. Adrenal glands are the site of solitary synchronous and metachronous metastases in non-small cell lung cancer (NSCLC). The presence of solitary adrenal metastasis from lung cancer provides survival benefit; however, currently, there are no exact treatment algorithms. Objectives of the study: to assess shortand long-term treatment outcomes in patients with adrenal metastases from NSCLC. Material and methods. Treatment outcomes of patients undergoing adrenalectomy for NSCLC were analyzed. Results. From 1993 to 2014, 13 patients (11 males/2 females aged between 44 and 78, median age 58 years) with solitary adrenal metastases (adenocarcinoma (n=7), squamous cell carcinoma (n=4), large cell carcinoma (n=2); synchronous metastases – 5 cases (38.5%) and metachronous metastases – 8 cases (61.5 %), underwent adrenalectomy (one patient was given stereotactic radiation therapy for brain metastasis). Laparoscopic adrenalectomy was performed in 10 (76.9 %) cases, open adrenalectomy was performed in 3 (23.1 %) cases. The average adrenal tumor diameter was 74.6 ± 13.3 mm (25–170 mm). In the early postoperative period, two lethal outcomes were recorded. The median follow-up time after adrenalectomy was 20 months (3 to 267 months), the average follow-up time was 51.5 ± 23.5 months. The 3-year overall survival rates in patients with synchronous and metachronous metastases were 25.0 ± 2.2 % and 57.1 ± 1.9 %, respectively; however, the differences were not statistically significant (p=0.63; LogRank). The extent of surgery, morphological tumor type and status of regional lymph nodes produced no influence on the survival rate (p>0.05). Conclusion. No factors influencing survival in patients with solitary adrenal metastases from NSCLC were identified. © 2020, Tomsk National Research Medical Center of the Russian Academy of Sciences. All rights reserved

Adrenal gland as a target of synchronous and metacronous metastasis from renal cell carcinoma: results of surgical treatment in a single institution

Background. Surgical treatment of solitary and oligometastatic metastases in renal cell carcinoma (RCC) is one of the treatment options for modern oncology. The objective of study to compare surgical outcomes in treatment of synchronous and metachronous solitary metastatic adrenal tumors in RCC. Materials and methods. The study included 93 patients with kidney cancer, from 1997 till 2018, who underwent surgical treatment in the urological oncology department of the P.A. Hertzen Moscow Oncology Research Institute. The 1st group is represented by 58 patients with RCC and synchronous secondary adrenal gland lesion, who underwent simultaneous surgery, consist of radical nephrectomy and adrenalectomy without subsequent adjuvant therapy. The 2nd group included 35 patients with metachronous solitary metastatic adrenal gland lesion who underwent surgical treatment. Results. The progression of disease to left adrenal gland was observed in 40 (43.0 %) cases, to the right - in 39 (41.9 %), both adrenal glands - 14 (15.1 %) cases. The median diameter of the adrenal tumors was 44 (4-170) mm, the most common in both groups were tumors less than 5 cm (58.1 %). The sensitivity of ultrasound in the diagnosis of adrenal tumors was 80.6 %, computed tomography - 93.5 %, adrenal biopsy - 73.9 %. The median of the observation time was 42 months (1st group - 24 months, 2nd group - the median was not achieved). The one-year survival of patients with a metachronous lesion of adrenal was 82.3 +/- 76.6 % versus 52.8 +/- 7.1 % in the synchronous lesion group, three-year survival was 79.2 +/- 7.0 % versus 32.3 +/- 7.6 % and five-year - 57.0 +/- 10.0 % versus 16.2 +/- 12.0 %, respectively. In multivariate analysis, only a metachronous lesion is a factor of favorable prognosis (p = 0.002). Conclusion. Surgical treatment for metachronous adrenal gland metastatic lesions is appropriate intervention and provides better patient survival rates compared to synchronous lesions

Enhancement of the rate of radiative processes in the field of a magnetic monopole

Supported in part by the Advance Researches Foundation of BelarusConsiglio Nazionale delle Ricerche (CNR). Biblioteca Centrale / CNR - Consiglio Nazionale delle RichercheSIGLEITItal

LAPAROSCOPIC RESECTION OF THE HORSESHOE KIDNEY FOR RENAL CELL CARCINOMA

Renal fusion is one of the most common kidney anomalies. The most frequent is horseshoe kidney, characterized by a fusion of the poles (typically the lower poles) of the kidneys. We described a clinical case of a malignant tumor in the right half of the horseshoe kidney (stage 1 cancer, CT1aN0M0) in a man aged 65 years, who underwent laparoscopic resection. It was shown that laparoscopy is no less efficient than open surgery. However, in planning the operation, it is necessary to use spiral computed tomography for three-dimensional reconstruction of the organ and identification of its anatomical features caused by aberrant blood supply to horseshoe kidney

Реабилитационный эффект коррекции эректильной дисфункции у больных, перенесших радикальную простатэктомию по поводу рака предстательной железы

Purpose. To investigate the effect of the development of erectile dysfunction (ED) in patients with prostate cancer after radical prostatectomy (RPE) on the assessment of these patients' quality of life and their psychological state and the influence on these parameters of ED treatment by implantation of the prosthesis of the penis. Materials and methods. The material of the study was analysis of the questionnaire data of 30 patients with PC with the postoperative ED before the postoperative period and after the falloprosthesis. In the long-term postoperative period (2-3 years) patients (n = 30) with an ED stand, who wanted to restore sexual function, were installed a 3-component prosthesis of the penis. The comparison group consisted of 38 patients, examined 3 years after RPE. The second comparison group consisted of 28 patients who were examined prior to surgical treatment. The questioning of patients was carried out using the questionnaire MIEF-5, which characterizes the state of sexual function, and the psychological test of Spielberger-Khanin for assessing anxiety. Results. It was shown that the sum of the points of situational anxiety after prosthetics of the penis decreased from 32.4 ± 3.6 to 17.4 ± 1.5 points (p = 3.74-5), and personal anxiety - from 43.7 ± 2.2 to 33.0 ± 1.2 points (p = 1.71-5); and, these differences are statistically highly reliable. Accordingly, the evaluation of sexual function shifted in a positive direction (all patients confirmed satisfaction with the restored sexual function). Сonclusion. The results attest to the high rehabilitation efficiency of correction of ED, which developed after RP, by installing a falloprosthesis.Цель исследования. Исследование влияния развития эректильной дисфункции (ЭД) у больных раком предстательной железы (РПЖ) после радикальной простатэктомии (РПЭ) на оценку этими больными качества жизни и своего психологического состояния и влияние на эти параметры лечения ЭД путем имплантации протеза полового члена. Материалы и методы. Материал исследования составил анализ данных анкетирования 30 больных РПЖ с развившейся после РПЭ стойкой ЭД до и после фаллопротезирования. В отдаленном послеоперационном периоде (2-3 года) пациентам ( n = 30) со стойкой ЭД, желающим восстановить сексуальную функцию, был установлен 3-компонентный протез полового члена. Группу сравнения составили 38 пациентов, обследованных через 3 года после РПЭ. Второй группой сравнения были 28 больных, обследованных до оперативного лечения. Анкетирование пациентов проводили с помощью опросника МИЭФ-5, характеризующего состояние сексуальной функции, и психологического теста Спилбергера-Ханина - для оценки тревожности. Результаты. Показано, что сумма баллов ситуационной тревожности после фаллопротезирования уменьшилась с 32,4 ± 3,6 до 17,4 ± 1,5 балла ( р = 3,74-5), а личностной тревожности - с 43,7 ± 2,2 до 33,0 ± 1,2 балла ( р = 1,71-5); причем эти различия статистически высокодостоверны. Соответственно, в позитивную сторону смещалась оценка половой функции (все пациенты подтвердили удовлетворенность восстановленной половой функцией). Заключение. Результаты свидетельствуют о высокой реабилитационной эффективности коррекции ЭД, развившейся после РПЭ, путем установки фаллопротеза

Реабилитационный эффект коррекции эректильной дисфункции у больных, перенесших радикальную простатэктомию по поводу рака предстательной железы

Purpose. To investigate the effect of the development of erectile dysfunction (ED) in patients with prostate cancer after radical prostatectomy (RPE) on the assessment of these patients' quality of life and their psychological state and the influence on these parameters of ED treatment by implantation of the prosthesis of the penis. Materials and methods. The material of the study was analysis of the questionnaire data of 30 patients with PC with the postoperative ED before the postoperative period and after the falloprosthesis. In the long-term postoperative period (2-3 years) patients (n = 30) with an ED stand, who wanted to restore sexual function, were installed a 3-component prosthesis of the penis. The comparison group consisted of 38 patients, examined 3 years after RPE. The second comparison group consisted of 28 patients who were examined prior to surgical treatment. The questioning of patients was carried out using the questionnaire MIEF-5, which characterizes the state of sexual function, and the psychological test of Spielberger-Khanin for assessing anxiety. Results. It was shown that the sum of the points of situational anxiety after prosthetics of the penis decreased from 32.4 ± 3.6 to 17.4 ± 1.5 points (p = 3.74-5), and personal anxiety - from 43.7 ± 2.2 to 33.0 ± 1.2 points (p = 1.71-5); and, these differences are statistically highly reliable. Accordingly, the evaluation of sexual function shifted in a positive direction (all patients confirmed satisfaction with the restored sexual function). Сonclusion. The results attest to the high rehabilitation efficiency of correction of ED, which developed after RP, by installing a falloprosthesis.Цель исследования. Исследование влияния развития эректильной дисфункции (ЭД) у больных раком предстательной железы (РПЖ) после радикальной простатэктомии (РПЭ) на оценку этими больными качества жизни и своего психологического состояния и влияние на эти параметры лечения ЭД путем имплантации протеза полового члена. Материалы и методы. Материал исследования составил анализ данных анкетирования 30 больных РПЖ с развившейся после РПЭ стойкой ЭД до и после фаллопротезирования. В отдаленном послеоперационном периоде (2-3 года) пациентам ( n = 30) со стойкой ЭД, желающим восстановить сексуальную функцию, был установлен 3-компонентный протез полового члена. Группу сравнения составили 38 пациентов, обследованных через 3 года после РПЭ. Второй группой сравнения были 28 больных, обследованных до оперативного лечения. Анкетирование пациентов проводили с помощью опросника МИЭФ-5, характеризующего состояние сексуальной функции, и психологического теста Спилбергера-Ханина - для оценки тревожности. Результаты. Показано, что сумма баллов ситуационной тревожности после фаллопротезирования уменьшилась с 32,4 ± 3,6 до 17,4 ± 1,5 балла ( р = 3,74-5), а личностной тревожности - с 43,7 ± 2,2 до 33,0 ± 1,2 балла ( р = 1,71-5); причем эти различия статистически высокодостоверны. Соответственно, в позитивную сторону смещалась оценка половой функции (все пациенты подтвердили удовлетворенность восстановленной половой функцией). Заключение. Результаты свидетельствуют о высокой реабилитационной эффективности коррекции ЭД, развившейся после РПЭ, путем установки фаллопротеза

Linseed essential oil - source of lipids as active ingredients for pharmaceuticals and nutraceuticals

Linseed - also known as flaxseed - is known for its beneficial effects on animal health attributed to its composition. Linseed comprises linoleic and ?-linolenic fatty acids, various dietary fibers and lignans, which are beneficial to health because they reduce the risk of cardiovascular diseases, as well as cancer, decreasing the levels of cholesterol and relaxing the smooth muscle cells in arteries increasing the blood flow. Essential fatty acids from flax participate in several metabolic processes of the cell, not only as structuring components of the cell membrane but also as storage lipids. Flax, being considered a functional food, can be consumed in a variety of ways, including seeds, oil or flour, contributing to basic nutrition. Several formulations containing flax are available on the market in the form of e.g. capsules and microencapsulated powders having potential as nutraceuticals. This paper revises the different lipid classes found in flaxseeds and their genomics. It also discusses the beneficial effects of flax and flaxseed oil and their biological advantages as ingredients in pharmaceuticals and in nutraceuticals products.The authors wish to acknowledge the financial support from the Portuguese Science and Technology Foundation, Ministry of Science and Education (FCT/MEC) through national funds, and co-financed by FEDER, under the Partnership Agreement PT2020 for the project M-ERA-NET/0004/2015-PAIRED.info:eu-repo/semantics/publishedVersio