Comparison of Sertraline and Citalopram for Treatment of Premature Ejaculation

Normal 0 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Introduction: We evaluated the efficacy of citalopram and sertraline in the treatment of premature ejaculation (PE). Materials and Methods: Of 101 married men with PE, 80 were eligible and consented to participate in this randomized controlled trial. Erectile dysfunction and administration of drugs for the treatment of PE were the exclusion criteria. The patients were evaluated using index of premature ejaculation (IPE) questionnaire and were randomly assigned into groups 1 (sertraline) and 2 (citalopram). They received one of these drugs for 8 weeks and then were re-evaluated by the IPE. Pretreatment and posttreatment results were compared within and between the study groups. Results: A total of 80 patients entered and completed the study. The mean age of the patients was 38.4 ± 7.7 in group 1 and 37.5 ± 6.9 in group 2 (P = .60). The mean pretreatment IPE scores were 21.4 ± 1.8 and 20.9 ± 1.3 in the patients of groups 1 and 2, respectively (P = .23). After 8 weeks, significant improvement was seen in both groups in terms of the IPE questionnaire results (39.8 ± 1.4; P P P = .50). No serious adverse effects were detected in any of the patients and both drugs were tolerated well. Conclusion: Citalopram and sertraline are safe and effective in patients with PE. Additionally, we failed to find any difference between the effects of these two drugs in the treatment of this condition.</p

Is a contrast study really necessary prior to ureteroscopy?

This study aimed to evaluate the effect of preoperative imaging techniques on the success and complication rates of ureteroscopy. We performed a retrospective analysis of 736 patients (455 males and 281 females), with a mean age of 45.5±15.2 years (range, 1–88 years), who underwent rigid ureteroscopic procedures for removal of ureteral stones. Patients were divided into 4 groups according to the type of imaging modality used: group I, intravenous urography (n=116); group II, computed tomography (n=381); group III, computed tomography and intravenous urography (n=91), and group IV, ultrasonography and abdominal plain film (n=148). Patients’ demographics, stone size and location, prior shock wave lithotripsy, lithotripsy technique, operation time, success rate, and rate of intraoperative complications were compared among the groups. There were no significant differences in success and complication rates among the groups. The stone-free rate after primary ureteroscopy was 87.1% in group I, 88.2% in group II, 96.7% in group III, and 89.9% in group IV (P=0.093). The overall incidence of intraoperative complications was 11.8%. According to the modified Satava classification system, 6.1% of patients had grade 1, 5.1% had grade 2, and 0.54% had grade 3 complications. Intraoperative complications developed in 12.1% of patients in group I, 12.6% of patients in group II, 7.7% of patients in group III, and 12.2% of patients in group IV (P=0.625). Our findings clearly demonstrate that ureteroscopic treatment of ureteral stones can be safely and effectively performed with no use of contrast study imaging, except in doubtful cases of anatomical abnormalities

The effect of local anesthesia types on erectile function in TRUS biopsy: A prospective study

Aim: To evaluate the effect of local anesthesia types on erectile function during transrectal ultrasound guided biopsy (TRUS-Bx).Material and Methods: Between February 2014 and February 2015, 50 men who underwent TRUS-Bx at our institution were included in this prospective study. The 50 patients were randomized and divided into two groups according to the type of anesthesia used. All patients were asked to indicate the level of pain experienced on a visual analogue scale (VAS) 10 min after the TRUS biopsy. All patients had to fill in the IIEF standardized questionnaire. Groups were evaluated in terms of pre-biopsy IEFF score (IIEF-1), post-biopsy 1st month IIEF score (IIEF-2) and post-biopsy 2nd month IIEF score (IIEF -3). Patient characteristics, mean VAS score and IIEF score were compared between the two groups.Results: The mean age,IIEF-1,tPSA level, prostate volume and VAS score were 60.86±0.95 years,18.68,6.81±0.54 ng/ml,51.10±3.82 cc and 3.5±0.26 in all patients, respectively. The difference in VAS scores between the groups was statistically significant (p&lt;0.05). In Group 1 the IIEF-1, IIEF-2, and IIEF-3 were different from each other statistically. There was no statistically significant difference between IIEF-1 and IIEF-3 scores in group 2(p=0,136 z=-1,492).So it was observed that the initial IIEF scores were reached at the end of the second month in group 2 administered 12.5 g 2% lidocaine HCl jel.Conclusion: Our study indicates that although local periprostatic anesthesia by injecting 6 ml of 2% lidocaine provides more effective anesthesia for pain relief, intrarectal 12.5g 2% lidocaine HCl jel maintains less impact on erectile dysfunction for TRUS-Bx

G1733A (RS6152) polymorphism of the androgen receptor gene in patients with prostate cancer

Aim: The causes of prostate cancer development and molecular mechanism underlying its development and progression are not clearly understood. The aim of this study is to determine the frequency of G1733A (rs6152) polymorphism of the androgen receptor (AR) gene among patients with prostate cancer, and to examine the role of this polymorphism in the development of prostate cancer. Method: DNA samples isolated from 96 individuals (49 patients with prostate cancer and 47 controls) were analyzed with real time-polymerase chain reaction (real time-PCR) in order to determine G1733A (rs6152) polymorphism genotypes and allele frequencies in the AR gene. The results were evaluated statistically. Results: Genotype frequency was determined as 91% GG and 9% AG among the controls, and 67% GG and 33% AG among the patients. G allele frequency was 95% in controls and 83% in patients, whereas A allele frequency was 5% in controls and 17% in patients. There was a statistically significant difference between patient and control groups regarding genotype frequency (p&lt;0.05). Conclusion: Based on the results of our study, we can infer that G1733A (rs6152) polymorphism of the AR gene plays a role in development of prostate cancer in the Turkish population

Ultrastructural Analysis of Urinary Stones by Microfocus Computed Tomography and Comparison with Chemical Analysis

Objective: To investigate the ultra-structure of urinary system stones using micro-focus computed tomography (MCT), which makes non-destructive analysis and to compare with wet chemical analysis. Methods: This study was carried out at the Ankara Train­ing and Research hospital. Renal stones, removed from 30 patients during percutaneous nephrolithotomy (PNL) surgery, were included in the study. The stones were blindly evaluated by the specialists with MCT and chemi­cal analysis. Results: The comparison of the stone components be­tween chemical analysis and MCT, showed that the rate of consistence was very low (p0.05). It was also seen that there was no significant relation between its 3D structure being heterogeneous or homogenous. Conclusion: The stone analysis with MCT is a time con­suming and costly method. This method is useful to un­derstand the mechanisms of stone formation and an im­portant guide to develop the future treatment modalities

Efficiency of Imaging Methods Prior to Percutaneous Nephrolithotomy

The most important step of percutaneous nephrolithotomy (PCNL) is planning the puncture site. A well selected puncture will facilitate nephroscopic navigation and stone clearance. The traditional methods for planning the puncture are intravenous urogram or retrograde pyelogram. Either of these imaging tools is adequate, but new tools such as 3D reconstructed tomography should be more accurate. Many recently developed imaging tools are promising, but no one is still ideal. The imaging techniques that we currently use have specific advantages and disadvantages. The purpose of this review is to summarise different imaging tools and their effectiveness prior to PCNL

Intraperitoneal stone migration during percutaneos nephrolithotomy

Percutaneos nephrolithotomy (PNL) is the standard care for renal stones larger than 2 cm. The procedure has some major and minor complications. Renal pelvis laceration and stone migration to the retroperitoneum is one of the rare condition. We report the first case of intraperitoneal stone migration during PNL

Evaluation of Urinary Stones Ex Vivo With Micro-Computed Tomography: Preliminary Results of an Investigational Technique

Purpose: To evaluate the ultrastructural features of the urinary stonesremoved with endoscopic stone surgery, using micro computed tomography(micro-CT).Materials and Methods: Patients who had endoscopic surgery for renalor ureteral stones removal were included in this study. After surgery, thestones were classified into three groups and investigated with Skyscan 1174micro-CT. Group I underwent percutaneous nephrolithotomy (PNL) withultrasonic lithotripsy; group II had ureteroscopic stone surgery (USS) withpneumatic lithotripsy; and group III (the control group) had stone removalwith USS or PNL without lithotripsy. Stone homogeneity, voids, and theinternal structure of the stones were evaluated. Chi-square test was used toevaluate the difference statistically. P values less than .05 were consideredstatistically significant.Results: A total of 24 “calcium oxalate monohydrate” stones from 24patients were scanned with micro-CT. Stones treated with ultrasoniclithotripsy (group I) were more fragile, fragmented, and cracked than thosetreated with the pneumatic lithotripsy (group II; P = .01). Stones in groupII were more homogeneous and smooth than those in group I and resembled those of the control group (P = .02). Homogeneous, non-fragile stones andheterogeneous, fragile calculi were seen in all groups.Conclusion: The stone fragility could be confirmed by micro-CTinvestigation. Ultrasonic lithotripters increase the stone fragility, which isdemonstrated with increased heterogeneity by micro-CT

Ureteral Stricture after Laparoscopic Tubal Ligation due to Suturing of the Serosa

Strictures secondary to traumas of the ureter are some of the complications of urogynecologic surgery. We present a 43-year-old female who had a history of laparoscopic tubal ligation a year ago and was admitted to our department with recurrent flank and inguinal pain. It was soon understood that a suture has pulled the ureter from the lateral serosa of the upper part to the lateral serosa of the lower part causing dilatation of the proximal and midureter because of the previous surgery while there was no damage on the ureteral lumen. Consequently successful reconstruction was performed with open ureteroureterostomy

Combined Radiation and Hormonal Therapy for Squamous Cell Carcinoma of the Prostate: A Case Report and Review of the Literature

Squamous cell carcinoma (SCC) of the prostate is a rare entity, with a prevalence of 0.6-1% among all prostatic carcinomas. Prostatic SCC has a poor prognosis. Although there are a number of treatment modalities, none of them have promised a long-term survival. Herein, we report a case of SCC coexisting with adenocarcinoma of the prostate treated with a combination of hormonal therapy, leuprolide acetate, and radiotherapy. Twenty-four months after treatment, the patient did not progress into metastatic or end-stage disease with the combination treatment modality. The treatment modalities for SCC are still limited. Comparisons of surgery and radiotherapy, and chemotherapy and hormonal therapy showed that they were all ineffective. Combined radiotherapy and hormone therapy may hold promise for longer survival