Continued administration of antithrombotic agents during transperineal prostate biopsy

Purpose To determine the safety of continued administration of antithrombotic agents during transperineal (TP) prostate biopsy. Patients and Methods A total of 811 men who underwent transrectal ultrasound (TRUS)-guided TP biopsy from January 2008 to June 2012 at our two institutions were retrospectively analyzed. Among these 811 men, 672 received no antithrombotic agents (group I), 103 received and continued administration of antithrombotic agents (group II), and 36 interrupted administration of antithrombotic agents (group III). Overall complications were graded and hemorrhagic complications were compared (group I with group II) using propensity score matching (PSM) analysis. Results An overall complication rate of 4.6% was recorded. Hemorrhagic complications occurred in 1.8% and they were virtually identical in all the three groups, and no severe hemorrhagic complications occurred. One patient in group III required intensive care unit admission for cerebral infarction. PSM analysis revealed no statistical difference between groups I and II with regard to the incidence of gross hematuria, perineal hematoma, and rectal bleeding. Multiple regression analysis revealed that hemorrhagic complications were associated with lower body mass index (<21 kg/m2, P=0.0058), but not with administration of antithrombotic agents. Conclusions Continued administration of antithrombotic agents does not increase the risk of hemorrhagic complications; these agents are well tolerated during TP biopsy

Stable operation of a self-amplified spontaneous-emission free-electron laser in the extremely ultraviolet region

We achieved stable operation of a free-electron laser (FEL) based on the self-amplified spontaneous-emission (SASE) scheme at the SPring-8 Compact SASE Source (SCSS) test accelerator in the extremely ultraviolet region. Saturation of the SASE FEL power has been achieved at wavelengths ranging from 50 to 60 nm. The pulse energy has reached ∼30  μJ at 60 nm. The observed fluctuation of the pulse energy is about 10% (standard deviation) for several hours, which agrees with the expectation from the SASE theory showing the stable operation of the accelerator. The SASE FEL has been routinely operated to provide photon beams for user experiments over a period of a few weeks. Analysis on the experimental data gave the normalized-slice emittance at the lasing part is around 0.7π   mm mrad. This result indicates that the normalized-slice emittance of the initial electron beam, 0.6π   mm mrad in a 90% core part, is kept almost unchanged after the bunch compression process with a compression factor of approximately 300. The success of the SCSS test accelerator strongly encourages the realization of a compact XFEL source