Tunable Backward Terahertz-wave Parametric Oscillation

Backward optical parametric oscillation has attracted attention for cavityless spectral narrowband generation based on perfect photon conversion. Few demonstrations have shown its potential from the aspect of nonlinear photonics; therefore, the mechanisms of momentum conservation among interacting light waves have been concealed by the restricted configuration under the phase-matching condition of periodically poled structures. Here, we unveil a tunable mechanism in the terahertz region by active control of the phase-matching condition. The tunability of backward terahertz-wave parametric oscillation is investigated using a quasi-collinear phase-matching model and its frequency range from the sub-terahertz to terahertz region is identified. Transform-limited terahertz-wave pulse is achieved simply by installing a device on the pump propagating line with no cavity. Moreover, the cascading terahertz-wave generation enhances the photon conversion efficiency, thus making nonlinear optics and its applications more promising. The results highlight new capabilities for using modern ferroelectric materials and encourage further research on nonlinear optics

Materials processing with tightly focused femtosecond vortex laser beams

This letter is the first demonstration of material modification using tightly focused femtosecond laser vortex beams. Double-charge femtosecond vortices were synthesized with the polarization-singularity beam converter described in Ref [1] and then focused using moderate and high numerical aperture optics (viz., NA = 0.45 and 0.9) to ablate fused silica and soda-lime glasses. By controlling the pulse energy we consistently machine high-quality micron-size ring-shaped structures with less than 100 nm uniform groove thickness.Comment: 8 pages, 3 figures, 10 references; submitted to Appl. Phys. Lett. on May 31, 201

Superoxide dismutase analog (Tempol: 4-hydroxy-2, 2, 6, 6-tetramethylpiperidine 1-oxyl) treatment restores erectile function in diabetes-induced impotence.

We hypothesized that the administration of the superoxide dismutase (SOD) mimetic Tempol (4-hydroxy-2, 2, 6, 6-tetramethylpiperidine 1-oxyl) may reverse diabetes-induced erectile dysfunction. To test this hypothesis, reactive oxygen species-related genes (SOD1, SOD2, GP x 1, CAT, NOS2, NOS3) were tested, erectile functional studies and immunohistochemical analysis were carried out in diabetic rats treated with or without Tempol. Thirty Sprague-Dawley (3-4 months old) rats were divided into three groups (n=10 each), 20 with diabetes (diabetic control and Tempol treatment) and 10 healthy controls. At 12 weeks after the induction of diabetes by streptozotocin and Tempol treatment, all groups underwent in vivo cavernous nerve stimulation. Rat crura were harvested and the expression of antioxidative defense enzymes were examined by semi-quantitative reverse transcriptase PCR (RT-PCR). To confirm the RT-PCR results, we carried out immunohistochemistry (IHC) for catalase (CAT) and iNOS (NOS2). Nitration of tyrosine groups in proteins was also examined by IHC. Mean intracavernous pressure in the diabetic group was significantly lower than in the healthy controls (P <0.001) and was reversed by Tempol treatment (P <0.0108). NOS2 protein expression was significantly increased in diabetic animals compared with healthy controls and Tempol restored NOS2 protein level. Nitrotyrosine was also higher in diabetic animals and although Tempol treatment decreased its formation, it remained higher than that found in healthy controls. This study suggests that Tempol treatment increased erectile function through modulating oxidative stress-related genes in diabetic rats. This is the first report about the relationship between diabetes-induced erectile dysfunction and oxidative stress, and antioxidative therapy using the superoxide dismutase mimetic, Tempol, to restore erectile function

Incident-Angle-Dependent Extraordinary Transmission of the Terahertz Bull’s-Eye Structure

The bull’s-eye structure in the terahertz (THz) frequency region has ample applications owing to its ability to focus free-propagating waves into subwavelength apertures, resulting in enhanced transmission, that is, extraordinary transmission. However, its coupling properties have been primarily discussed in terms of the normal plane-wave incidence to the structure. In this study, we investigate the multiple resonances in extraordinary transmission with normal and oblique incident waves. The experiment using a widely tunable and high-power THz wave source revealed two types of resonances. The main resonance split depends on the incident angle, and the other corresponds to the side lobe of the main resonances. The results are explained by a simple analytical model using a finite number of scattering media. The analysis is supported by the full-wave simulation using the finite-element method, which agrees with the experimental results. The coupling mechanisms will be applicable to design devices, such as THz biosensing devices or THz antennas for rapid communication systems

Nanometer-precision surface metrology of millimeter-size stepped objects using full-cascade-linked synthetic-wavelength digital holography using a line-by-line full-mode-extracted optical frequency comb

Digital holography (DH) is a powerful tool for surface profilometry of objects with sub-wavelength precision. In this article, we demonstrate full-cascade-linked synthetic-wavelength DH (FCL-SW-DH) for nanometer-precision surface metrology of millimeter-size stepped objects. 300 modes of optical frequency comb (OFC) with different wavelengths are sequentially extracted at a step of mode spacing from a 10GHz-spacing, 3.72THz-spanning electro-optic modulator OFC (EOM-OFC). The resulting 299 synthetic wavelengths and a single optical wavelength are used to generate a fine-step wide-range cascade link covering within a wavelength range of 1.54 um to 29.7 mm. We determine the 0.1000mm-stepped surface with axial uncertainty of 6.1 nm within the maximum axial range of 14.85 mm.Comment: 22 pages, 6 figure

Low phase noise THz generation from a fiber-referenced Kerr microresonator soliton comb

THz oscillators generated via frequency-multiplication of microwaves are facing difficulty in achieving low phase noise. Photonics-based techniques, in which optical two tones are translated to a THz wave through opto-electronic conversion, are promising if the relative phase noise between the two tones is well suppressed. Here, a THz (≈560 GHz) wave with a low phase noise is provided by a frequency-stabilized, dissipative Kerr microresonator soliton comb. The repetition frequency of the comb is stabilized to a long fiber in a two-wavelength delayed self-heterodyne interferometer, significantly reducing the phase noise of the THz wave. A measurement technique to characterize the phase noise of the THz wave beyond the limit of a frequency-multiplied microwave is also demonstrated, showing the superior phase noise of the THz wave to any other photonic THz oscillators (>300 GHz)

Low phase noise THz generation from a fiber-referenced Kerr microresonator soliton comb

THz oscillators generated via frequency-multiplication of microwaves are facing difficulty in achieving low phase noise. Photonics-based techniques, in which optical two tones are translated to a THz wave through opto-electronic conversion, are promising if the relative phase noise between the two tones is well suppressed. Here, a THz ($\approx$ 560 GHz) wave with an unprecedented phase noise is provided by a frequency-stabilized, dissipative Kerr microresonator soliton comb. The repetition frequency of the comb is stabilized to a long fiber in a two-wavelength delayed self-heterodyne interferometer, significantly reducing the phase noise of the THz wave. A new measurement technique to characterize the phase noise of the THz wave beyond the limit of a frequency-multiplied microwave is also demonstrated, showing the superior phase noise of the THz wave to any other THz oscillators (> 300 GHz)

Full-field fluorescence lifetime dual-comb microscopy using spectral mapping and frequency multiplexing of dual-comb optical beats

Fluorescence lifetime imaging microscopy (FLIM) is a powerful tool for quantitative fluorescence imaging because fluorescence lifetime is independent of concentration of fluorescent molecules or excitation/detection efficiency and is robust to photobleaching. However, since most FLIMs are based on point-to-point measurements, mechanical scanning of a focal spot is needed for forming an image, which hampers rapid imaging. Here, we demonstrate scan-less full-field FLIM based on a one-to-one correspondence between two-dimensional (2D) image pixels and frequency-multiplexed radio frequency (RF) signals. A vast number of dual-comb optical beats between dual optical frequency combs are effectively adopted for 2D spectral mapping and high-density frequency multiplexing in the RF region. Bimodal images of fluorescence amplitude and lifetime are obtained with high quantitativeness from amplitude and phase spectra of fluorescence RF comb modes without the need for mechanical scanning. The parallelized FLIM will be useful for rapid quantitative fluorescence imaging in life science

Scan-less full-field fluorescence-lifetime dual-comb microscopy using two-dimensional spectral mapping and frequency multiplexing of dual-optical-comb beats

Fluorescence lifetime imaging microscopy (FLIM) is a powerful tool for quantitative fluorescence imaging because fluorescence lifetime is independent of concentration of fluorescent molecules or excitation/detection efficiency and is robust to photobleaching. However, since FLIM is based on point-to-point measurements, mechanical scanning of a focal spot is needed for forming an image, which hampers rapid imaging. In this article, we demonstrate scan-less full-field FLIM based on a one-to-one correspondence between two-dimensional (2D) image pixels and frequency-multiplexed RF signals. A vast number of dual-optical-comb beats between dual optical frequency combs is effectively adopted for 2D spectral mapping and high-density frequency multiplexing in radio-frequency region. Bimodal images of fluorescence amplitude and lifetime are obtained with high quantitativeness from amplitude and phase spectra of fluorescence RF comb modes without the need for mechanical scanning. The proposed method will be useful for rapid quantitative fluorescence imaging in life science.Comment: 38 pages, 8 figures, 1 tabl