35 research outputs found
Increased amygdala reactivity following early life stress : a potential resilience enhancer role
Background: Amygdala hyper-reactivity is sometimes assumed to be a vulnerability factor that predates depression; however, in healthy people, who experience early life stress but do not become depressed, it may represent a resilience mechanism. We aimed to test these hypothesis examining whether increased amygdala activity in association with a history of early life stress (ELS) was negatively or positively associated with depressive symptoms and impact of negative life event stress in never-depressed adults.
Methods: Twenty-four healthy participants completed an individually tailored negative mood induction task during functional magnetic resonance imaging (fMRI) assessment along with evaluation of ELS.
Results: Mood change and amygdala reactivity were increased in never-depressed participants who reported ELS compared to participants who reported no ELS. Yet, increased amygdala reactivity lowered effects of ELS on depressive symptoms and negative life events stress. Amygdala reactivity also had positive functional connectivity with the bilateral DLPFC, motor cortex and striatum in people with ELS during sad memory recall.
Conclusions: Increased amygdala activity in those with ELS was associated with decreased symptoms and increased neural features, consistent with emotion regulation, suggesting that preservation of robust amygdala reactions may reflect a stress buffering or resilience enhancing factor against depression and negative stressful events
The Effect of Negative and Positive Emotionality on Associative Memory: An fMRI Study
In general, emotion is known to enhance memory processes. However, the effect of emotion on associative memory and the underling neural mechanisms remains largely unexplored. In this study, we explored brain activation during an associative memory task that involved the encoding and retrieval of word and face pairs. The word and face pairs consisted of either negative or positive words with neutral faces. Significant hippocampal activation was observed during both encoding and retrieval, regardless of whether the word was negative or positive. Negative and positive emotionality differentially affected the hemodynamic responses to encoding and retrieval in the amygdala, with increased responses during encoding negative word and face pairs. Furthermore, activation of the amygdala during encoding of negative word and neutral face pairs was inversely correlated with subsequent memory retrieval. These findings suggest that activation of the amygdala induced by negative emotion during encoding may disrupt associative memory performance
Characterization of autonomous Dart1 transposons belonging to the hAT superfamily in rice
An endogenous 0.6-kb rice DNA transposon, nDart1-0, was found as an active nonautonomous element in a mutable virescent line, pyl-v, displaying leaf variegations. Here, we demonstrated that the active autonomous element aDart in pyl-v corresponds to Dart1-27 on chromosome 6 in Nipponbare, which carries no active aDart elements, and that aDart and Dart1-27 are identical in their sequences and chromosomal locations, indicating that Dart1-27 is epigenetically silenced in Nipponbare. The identification of aDart in pyl-v was first performed by map-based cloning and by detection of the accumulated transposase transcripts. Subsequently, various transposition activities of the cloned Dart1-27 element from Nipponbare were demonstrated in Arabidopsis. Dart1-27 in Arabidopsis was able to excise nDart1-0 and Dart1-27 from cloned sites, generating footprints, and to integrate into new sites, generating 8-bp target site duplications. In addition to Dart1-27, Nipponbare contains 37 putative autonomous Dart1 elements because their putative transposase genes carry no apparent nonsense or frameshift mutations. Of these, at least four elements were shown to become active aDart elements in transgenic Arabidopsis plants, even though considerable sequence divergence arose among their transposases. Thus, these four Dart1 elements and Dart1-27 in Nipponbare must be potential autonomous elements silenced epigenetically. The regulatory and evolutionary implications of the autonomous Dart1 elements and the development of an efficient transposon-tagging system in rice are discussed
A Study on QOL at Facilities for People with Severe Motor and Intellectual Disabilities Based on Using the "Facility-Assessment Checklist".(Kawasaki Medical Welfare Journal Vol.7,No.1,1997 Abstracts)
A Study on QOL at Facilities for People with Severe Motor and Intellectual Disabilities Based on Using the "Facility-Assessment Checklist".(Kawasaki Medical Welfare Journal Vol.7,No.1,1997 Abstracts)
<Article>A Study of QOL for Adults with Severe Motor and Intellectual Disabilities Using the QOL Evaluation Items developed by Hughes, et al.(Kawasaki Medical Welfare Journal Vol.10,No.1,2000 Abstract)
<Article>A Study of QOL for Adults with Severe Motor and Intellectual Disabilities Using the QOL Evaluation Items developed by Hughes, et al.(Kawasaki Medical Welfare Journal Vol.10,No.1,2000 Abstract)
Importance of early lighting conditions in maternal care by dam as well as anxiety and memory later in life of offspring
Rodent studies have revealed that the early rearing environment plays an important role in the development of stress vulnerability, memory and cognition. Although early lighting conditions (ELC) are involved in these neuronal developments through both maternal and offspring behavior, their influence has not been fully elucidated. Thus, by using Sprague-Dawley strain rats, we examined whether ELC affected maternal care by the dam and the subsequent neurodevelopment of the offspring. Prolonged dark phase conditions (PDC; L/D=6:18h) and prolonged light phase conditions (PLC; L/D=18:6h) were administered from postnatal day 2 to postnatal day 14. Throughout this period, maternal care and circadian rhythmicity of dams were investigated. In adolescence and adulthood of the offspring, we measured anxiety-like behavior, social interaction, object recognition memory, activity rhythm and corticosterone response to stress with hippocampal expression of NMDA and glucocorticoid receptor mRNAs. PDC altered maternal care and circadian rhythmicity in the dam compared with normal lighting conditions (NLC) and PLC. PDC markedly increased anxiety-like behavior, decreased social interaction and object recognition memory and inhibited corticosterone feedback in offspring later in life. Furthermore, hippocampal levels of glucocorticoid receptor mRNA and NR2B mRNA in rats subjected to PDC were significantly lower than in animals subjected to NLC. In the adult offspring, the circadian rhythm of locomotor activity was not affected. These findings suggested that ELC affect mother-infant interactions and subsequently, at least partially alter neurobehavioral development of offspring