Entre emigración e integración. La percepción del extranjero como recurso productivo para la comunidad

Traducción de Ana María Rodrígue

Allogeneic Stem Cell Transplantation Compared with Chemotherapy for Poor-Risk Hodgkin Lymphoma

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Prevalence and Prognostic Role of IDH Mutations in Acute Myeloid Leukemia: Results of the GIMEMA AML1516 Protocol

IDH1/2 mutations are common in acute myeloid leukemia (AML) and represent a therapeutic target. The GIMEMA AML1516 observational protocol was designed to study the prevalence of IDH1/2 mutations and associations with clinico-biological parameters in a cohort of Italian AML patients. We analyzed a cohort of 284 AML consecutive patients at diagnosis, 139 females and 145 males, of a median age of 65 years (range: 19–86). Of these, 38 (14%) harbored IDH1 and 51 (18%) IDH2 mutations. IDH1/2 mutations were significantly associated with WHO PS >2 (p < 0.001) and non-complex karyotype (p = 0.021) when compared to IDH1/2-WT. Furthermore, patients with IDH1 mutations were more frequently NPM1-mutated (p = 0.007) and had a higher platelet count (p = 0.036). At relapse, IDH1/2 mutations were detected in 6 (25%) patients. As per the outcome, 60.5% of IDH1/2-mutated patients achieved complete remission; overall survival and event-free survival at 2 years were 44.5% and 36.1%, respectively: these rates were similar to IDH1/2-WT. In IDH1/2-mutated patients, high WBC proved to be an independent prognostic factor for survival. In conclusion, the GIMEMA AML1516 confirms that IDH1/2 mutations are frequently detected at diagnosis and underlines the importance of recognizing IDH1/2-mutated cases up-front to offer the most appropriate therapeutic strategy, given the availability of IDH1/2 inhibitors

Esempi di alfabetismo nella campagna romana in età imperiale (Italia e province occidentali)

It can be useful for the life within the vici to be able to write and read: we can find traces of this in the authors de re rustica, but also in some passages of the latin literature (e.g. Pliny the Elder and Pliny the Jounger). In this article we collect and analyse some evidences both juridical and epigraphic to testify that magistri primae litterae teach the rudiments of writing in the villages. We examine how this form of teaching was organized and what is the goal of this practice. The results of this research offer a contribution to the debate about the Roman alphabetization and its spread in the countryside

La diplomatie romaine sous la République: réflexions sur une pratique. Actes des rencontres de Paris (21-22 juin 2013) et Genéve (31 octobre-1er novembre 2013). B. Grass, G. Stouder éds.,

Recensione ad un volume miscellaneo sulla diplomazia a roma, esito di un convegno svoltosi nel 2013; la discussione degli articoli consente riflessioni sui meccanismi e le pratiche di una condotta "diplomatica" nel solco delle strategie della comunicazione e in relazione ai codici roman