Per un lessico del popolamento del vicus

Le fonti antiche (epigrafiche e letterarie) riguardo ai vici contengono alcune informazioni utili a ricostruire una forma di organizzazione del popolamento dei vici. Vicani, possessores, inquilini, habitantes sono le categorie attestate. In questo lavoro si cerca di stabilire il loro significato e il reciproco rapporto.Les sources antiques, épigraphiques et littéraires, sur les vici contiennent des informations utiles qui nous permettent de reconnaître une forme d’organisation du peuplement des vici en Italie. Vicani, possessores, inquilini, habitantes sont les catégories attestées. Dans cette étude nous essayons d’établir leur signification et la relation qui existe entre eux

Entre emigración e integración. La percepción del extranjero como recurso productivo para la comunidad

Traducción de Ana María Rodrígue

Allogeneic Stem Cell Transplantation Compared with Chemotherapy for Poor-Risk Hodgkin Lymphoma

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Prevalence and Prognostic Role of IDH Mutations in Acute Myeloid Leukemia: Results of the GIMEMA AML1516 Protocol

IDH1/2 mutations are common in acute myeloid leukemia (AML) and represent a therapeutic target. The GIMEMA AML1516 observational protocol was designed to study the prevalence of IDH1/2 mutations and associations with clinico-biological parameters in a cohort of Italian AML patients. We analyzed a cohort of 284 AML consecutive patients at diagnosis, 139 females and 145 males, of a median age of 65 years (range: 19–86). Of these, 38 (14%) harbored IDH1 and 51 (18%) IDH2 mutations. IDH1/2 mutations were significantly associated with WHO PS >2 (p < 0.001) and non-complex karyotype (p = 0.021) when compared to IDH1/2-WT. Furthermore, patients with IDH1 mutations were more frequently NPM1-mutated (p = 0.007) and had a higher platelet count (p = 0.036). At relapse, IDH1/2 mutations were detected in 6 (25%) patients. As per the outcome, 60.5% of IDH1/2-mutated patients achieved complete remission; overall survival and event-free survival at 2 years were 44.5% and 36.1%, respectively: these rates were similar to IDH1/2-WT. In IDH1/2-mutated patients, high WBC proved to be an independent prognostic factor for survival. In conclusion, the GIMEMA AML1516 confirms that IDH1/2 mutations are frequently detected at diagnosis and underlines the importance of recognizing IDH1/2-mutated cases up-front to offer the most appropriate therapeutic strategy, given the availability of IDH1/2 inhibitors

Clinical Features, Cardiovascular Risk Profile, and Therapeutic Trajectories of Patients with Type 2 Diabetes Candidate for Oral Semaglutide Therapy in the Italian Specialist Care

Introduction: This study aimed to address therapeutic inertia in the management of type 2 diabetes (T2D) by investigating the potential of early treatment with oral semaglutide. Methods: A cross-sectional survey was conducted between October 2021 and April 2022 among specialists treating individuals with T2D. A scientific committee designed a data collection form covering demographics, cardiovascular risk, glucose control metrics, ongoing therapies, and physician judgments on treatment appropriateness. Participants completed anonymous patient questionnaires reflecting routine clinical encounters. The preferred therapeutic regimen for each patient was also identified. Results: The analysis was conducted on 4449 patients initiating oral semaglutide. The population had a relatively short disease duration (42%  60% of patients, and more often than sitagliptin or empagliflozin. Conclusion: The study supports the potential of early implementation of oral semaglutide as a strategy to overcome therapeutic inertia and enhance T2D management

Esempi di alfabetismo nella campagna romana in età imperiale (Italia e province occidentali)

It can be useful for the life within the vici to be able to write and read: we can find traces of this in the authors de re rustica, but also in some passages of the latin literature (e.g. Pliny the Elder and Pliny the Jounger). In this article we collect and analyse some evidences both juridical and epigraphic to testify that magistri primae litterae teach the rudiments of writing in the villages. We examine how this form of teaching was organized and what is the goal of this practice. The results of this research offer a contribution to the debate about the Roman alphabetization and its spread in the countryside

Cicerone politico e la scientia civilium commutationum

This essay concerns Cicero's reflection about the role of the politicians towards the crisis of the res publica: they have to find solutions by reading the signs of time and they have to be ready to change direction when it is necessary in order to save the res publica. The communtationes that occurr in the State will be managed by politicians and used as an opportunity to overcome crisis, The forma rei publicae can also be changed: the most important thing is to save the substance of res publica, the vinculum iuri