89 research outputs found
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Alfalfa Pollination in Arizona: A Progress Report
This item is part of the Agricultural Experiment Station archive. It was digitized from a physical copy provided by the University Libraries at the University of Arizona. For more information, please email CALS Publications at [email protected]
Magnetic Resonance Imaging and Contralateral Prophylactic Mastectomy: The “No Más” Effect?
Surgical Standards for Management of the Axilla in Breast Cancer Clinical Trials with Pathological Complete Response Endpoint.
Advances in the surgical management of the axilla in patients treated with neoadjuvant chemotherapy, especially those with node positive disease at diagnosis, have led to changes in practice and more judicious use of axillary lymph node dissection that may minimize morbidity from surgery. However, there is still significant confusion about how to optimally manage the axilla, resulting in variation among practices. From the viewpoint of drug development, assessment of response to neoadjuvant chemotherapy remains paramount and appropriate assessment of residual disease-the primary endpoint of many drug therapy trials in the neoadjuvant setting-is critical. Therefore decreasing the variability, especially in a multicenter clinical trial setting, and establishing a minimum standard to ensure consistency in clinical trial data, without mandating axillary lymph node dissection, for all patients is necessary. The key elements which include proper staging and identification of nodal involvement at diagnosis, and appropriately targeted management of the axilla at the time of surgical resection are presented. The following protocols have been adopted as standard procedure by the I-SPY2 trial for management of axilla in patients with node positive disease, and present a framework for prospective clinical trials and practice
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Erratum: Author Correction: Surgical Standards for Management of the Axilla in Breast Cancer Clinical Trials with Pathological Complete Response Endpoint.
[This corrects the article DOI: 10.1038/s41523-018-0074-6.]
Understanding the circumgalactic medium is critical for understanding galaxy evolution
Galaxies evolve under the influence of gas flows between their interstellar
medium and their surrounding gaseous halos known as the circumgalactic medium
(CGM). The CGM is a major reservoir of galactic baryons and metals, and plays a
key role in the long cycles of accretion, feedback, and recycling of gas that
drive star formation. In order to fully understand the physical processes at
work within galaxies, it is therefore essential to have a firm understanding of
the composition, structure, kinematics, thermodynamics, and evolution of the
CGM. In this white paper we outline connections between the CGM and galactic
star formation histories, internal kinematics, chemical evolution, quenching,
satellite evolution, dark matter halo occupation, and the reionization of the
larger-scale intergalactic medium in light of the advances that will be made on
these topics in the 2020s. We argue that, in the next decade, fundamental
progress on all of these major issues depends critically on improved empirical
characterization and theoretical understanding of the CGM. In particular, we
discuss how future advances in spatially-resolved CGM observations at high
spectral resolution, broader characterization of the CGM across galaxy mass and
redshift, and expected breakthroughs in cosmological hydrodynamic simulations
will help resolve these major problems in galaxy evolution.Comment: Astro2020 Decadal Science White Pape
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Honey Bees Increase Alfalfa Seed Yields
This item is part of the Arizona Land and People (formerly Progressive Agriculture in Arizona) archive. It was digitized from a physical copy provided by the College of Agriculture and Life Sciences at The University of Arizona. For more information about this periodical, please email CALS Publications at [email protected]
Effects of contralateral prophylactic mastectomy on life expectancy using a Markov model
Alfalfa Pollination in Arizona
Prior to 1945, Arizona led the nation in per-acre alfalfa seed yields. This supremacy has been lost to California and Washington. While both acreage and yield per acre have declined in Arizona, the reverse has been the case in California (Table 1)
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