Genomic region of rs13279522.

<p>A ∼500 kb region centered around rs13279522 is from UCSC browser (<a href="http://genome.ucsc.edu" target="_blank">http://genome.ucsc.edu</a>). Linkage Disequilibrium (LD) information is color-coded at the bottom, genes (horizontal blue lines) and exons (vertical blue lines) are indicated above the LD representation. Vertical orange line correspond to the negative base 10 logarithm of the P value from a case only analysis of CARE and WOSCOPS for SNPs in this region. The location of rs13279522 is indicated by a black arrow.</p

Baseline characteristics of study participants.

<p>± values are standard deviation.</p

Study design.

<p>A flow chart outlining the patients and SNPs investigated in the 2 stages of the study.</p

Risk reduction according to genotype for rs13279522.

<p>Risk estimate and 95% confidence intervals are indicated for each genotype group in each study, as well as for the combined analysis of the studies. The number of individuals in each group is indicated.</p

P-values from a combined case-only analysis of CARE and WOSCOPS.

<p>Panel A: A Manhattan plot of the P values from the combined case-only analysis of CARE and WOSCOPS. The x-axis corresponds to the chromosomal position for 22 chromosomes and the X chromosome. The Y axis corresponds to the negative base 10 logarithm of the P value. The red line indicates P = 10⁻⁴ and SNPs above this line are indicated in blue. Gene symbols are indicated above loci with P<10^-5 in the combined analysis of CARE and WOSCOPS. The location of DNAJC5B is also indicated. Panel B: A quantile-quantile plot of the observed vs. expected P values. The black lines indicate the 95% CI associated with the expectation that, under the hypothesis of no association, the values will fall on the red diagonal.</p

Most significant SNPs associated with differential response to pravastatin therapy in a case-only combined analysis of CARE and WOSCOPS.

<p>Most significant SNPs associated with differential response to pravastatin therapy in a case-only combined analysis of CARE and WOSCOPS.</p

Individual and Combined analysis of 54 SNPs in CARE, WOSCOPS, and PROSPER/PHASE.

*<p>case-only data in CARE and WOSCOPS.</p>†<p>case-only data in WOSCOPS.</p