A probabilistic model for crystal growth applied to protein deposition at the microscale

A probabilistic discrete model for 2D protein crystal growth is presented. This model takes into account the available space and can describe growing processes of different nature due to the versatility of its parameters which gives the model great flexibility. The accuracy of the simulation is tested against a real protein (SbpA) crystallization experiment showing high agreement between the proposed model and the actual images of the nucleation process. Finally, it is also discussed how the regularity of the interface (i.e. the curve that separates the crystal from the substrate) affects to the evolution of the simulation.Comment: 13 pages, 12 figure

Scientific literature analysis of Judo in Web of Science

Although judo is a sport with great tradition that is practised worldwide, the state of the art and scientific advanc- es have not been analysed from a bibliometric point of view up to now. The aim of the present article is the status of the scientific production, collaboration, and impact of scientific pa- pers on judo, as well as the most active research groups working on this topic. Our analysis was based on documents retrieved from the Science Citation Index and Social Science Citation Index. Bibliometric analysis and network construction were performed using Histcite and Bibexcel software. As a result, 383 original papers and scientific reviews were retrieved from 162 journals in 78 Web of Science® cate- gories. Archives of Budo had the highest number of articles (56), and International Journal of Sports Medicine had the highest number of citations (192). More than half of the articles were within the area of sports science. The co- authorship network (threshold ≥3 articles) enabled us to identify 6 clusters of authors written in partnership. The citation network was formed mainly by 14 authors. Although research on judo is still at an early stage and has a lower profile than other sports, its development has potential interest to many scientific fields and sports in general. Judo research is mainly published in journals cov- ering sport science and sport medicine topics; the latter being the most cited ones. The co-authorship networks tended to be centralized, with a single lead author, while citation networks between authors were usually directed towards other areas of research.Peset Mancebo, MF.; Ferrer Sapena, A.; Villamón Herrera, M.; González Moreno, LM.; Toca Herrera, J.; Aleixandre Benavent, R. (2013). Scientific literature analysis of Judo in Web of Science. Archives of Budo. 9(2):81-91. http://hdl.handle.net/10251/43595S81919

The stiffness of elastomeric surfaces influences the mechanical properties of endothelial cells

Optimal characterization of the mechanical properties of both cells and their surrounding is an issue of major interest. Indeed, cell function and development are strongly influenced by external stimuli. Furthermore, a change in cell mechanics might, in some cases, associate with diseases or malfunctioning. In this work, atomic force microscopy (AFM) was applied to examine the mechanical properties of the silicone elastomer polydimethylsiloxane (PDMS) a common substrate in cell culture. Force spectroscopy analysis was done over different specimens of this elastomeric material containing varying ratios of resin to cross-linker in its structure (5:1, 10:1, 20:1, 30:1 and 50:1), which impacts the final material properties (e.g., stiffness, elasticity). To quantify the mechanical properties of the PDMS, factors as the modulus of Young, the maximum adhesive forces as well as both relaxation amplitudes and times upon constant height contact of the tip (dwell time different of zero) were calculated from the different segments forming the force curves. It is demonstrated that the material stiffness is increased by prior oxygen plasma treatment of the sample, required for hydrophilic switching, contrarily to what observed for its adhesiveness. Subsequent incubation of endothelial HUVEC cells on top of these plasma treated PDMS systems yields minor variation in cell mechanics in comparison to those obtained on a glass reference, on which cells show much higher spreading tendency and, by extension, a remarkable membrane hardening. Thus, surface wettability turns a factor of higher relevance than substrate stiffness inducing variations in the cell mechanics.Comment: manuscript (12 pages, 4 figures, 2 tables), supplementary information (2 pages and 3 figures), the main results of the manuscript are based on a master thesi

Stress relaxation and creep experiments with the atomic force microscope: a unified method to calculate elastic moduli and viscosities of biomaterials (and cells)

We show that the atomic force microscope can perform stress relaxation and creep compliance measurements on living cells. We propose a method to obtain the mechanical properties of the studied biomaterial: the relaxation time, the elastic moduli and the viscosity.Comment: 17 pages, three figure

Survival analysis of author keywords: An application to the library and information sciences area

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Our objective is to detect the new author keywords that appear in a fixed knowledge area in the period of 1 year in order to quantify the probabilities of survival for 10 years as a function of the impact of the journals where they appeared. Many of the new keywords appearing in the LIS field are ephemeral. Actually, more than half are never used again. In general, the terms most commonly used in the LIS area come from other areas. The average survival time of these keywords is approximately 3 years, being slightly higher in the case of words that were published in journals classified in the second quartile of the area. We believe that measuring the appearance and disappearance of terms will allow understanding some relevant aspects of the evolution of a discipline, providing in this way a new bibliometric approach.Peset Mancebo, MF.; Garzón Farinós, MF.; Gonzalez, L.; García-Massó, X.; Ferrer Sapena, A.; Toca-Herrera, JL.; Sánchez Pérez, EA. (2020). 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