Connection-wise comparison reveals significantly reduced connections in 6-OHDA rats compared shams.

<p>Glass brain depicting edges and their associated nodes that showed significantly reduced functional connectivity in 6-OHDA rats in comparison to sham rats. The size of a node represents the number of abnormal connections associated with that node. Significance was assessed using non-parametric permutation tests (N = 10000). A p-value below 0.05 was considered significant (FWER corrected). The results shown were generated at a primary NBS threshold of t = 3.1 with p = 0.0425, FWER corrected. 6-OHDA rats N = 13; sham rats N = 11. Bold L marks the lesion side. R, contralateral side.</p

Local differences on a nodal level in 6-OHDA rats compared to shams.

<p>Glass brains depicting nodes that showed significantly altered (A) node degree, (B) clustering coefficient and (C) node efficiency in 6-OHDA rats compared to shams. Nodes are represented as spheres and located in the glass brain according to their corresponding anatomical region’s centre mass. Blue spheres depict significantly lower, red spheres significantly higher values in 6-OHDA rats compared to shams. Significance was assessed using two-sample t-test by comparing the AUC of these network measures for each node across all network sparsities (0.05</p

Rat brain parcellation scheme showing 150 ROIs (75 on each hemisphere).

<p>Each bilateral ROI is labelled differently and overlaid onto coronal slices of the rat brain template.</p

Global network measures of segregation and integration across different network sparsities in 6-OHDA rats and shams.

<p>(A) Mean clustering coefficient C normalized to a random reference network. (B) Mean characteristic path length L normalized to a random reference network. (C) Small-worldness S. (D) Number of modules. (E) Modularity Q. (F) Global efficiency. Data are expressed as mean ± SEM. 6-OHDA rats N = 13; sham rats N = 11.</p