A Comparison of Women of Color and Non-Hispanic White Women on Factors Related to Leaving a Violent Relationship

This study compares women of color and non-Hispanic White women regarding the influence of socioeconomic status, family investment, and psychological abuse on leaving a violent relationship. It was found that most women who left stayed away for less than a month. Women of color and non-Hispanic White women did not differ in their length or rate of leaving, although women of color left more frequently when they did leave. Factors associated with leaving for both groups were threat with a weapon, psychological abuse, being single, and having fewer adults in the household. Women of color with higher socioeconomic status were less likely to leave, which was not the case for non-Hispanic White women. Non-Hispanic White women were more likely to leave if they had lived with their partners less than 5 years and had children at home.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90886/1/Lacey-Saunders-Zhang 2011-Women of color vs white women - factors in leaving violent relationahip JIV .pd

3D characterization of diffusivities and its impact on mass flux and concentration overpotential in SOFC anodes

In recent years great effort has been taken to understand the effect of gas transport on the performance of electrochemical devices. This study aims to characterize the diffusion regimes and the possible inaccuracies of the mass transport calculation in Solid Oxide Fuel Cell (SOFC) anodes when a volume-averaged pore diameter is used. 3D pore size distribution is measured based on the extracted pore phase from an X-ray CT scan, which is further used for the calculation of a Knudsen number (Kn) map in the porous medium, followed by the voxel-based distribution of the effective diffusion coefficients for different fuel gases. Diffusion fluxes in a binary gas mixture using the lower boundary, upper boundary and average effective coefficients are compared, and the impact on overpotential is analyzed. The results show that pore diameters from tens to hundreds of nanometers result in a broad range of Knudsen number (1.1 ∼ 4.8 and 0.6 ∼ 3 for H2 and CH4 respectively), indicative of the transitional diffusion regime. The results highlight that for a porous material, such as an SOFC anode where Knudsen effects are non-negligible, using a volume-averaged pore size can overestimate the mass flux by ±200% compared to the actual value. The characteristic pore size should be chosen sensibly in order to improve the reliability of the mass transport and electrochemical performance evaluation

Concurrent Acquisition of a Single Nucleotide Polymorphism in Diverse Influenza H5N1 Clade 2.2 Sub-clades

Highly pathogenic Influenza A H5N1 was first identified in Guangdong Province in 1996, followed by human cases in Hong Kong in 1997. The number of confirmed human cases now exceeds 300, and the associated Case Fatality Rate exceeds 60%. The genetic diversity of the serotype continues to increase. Four distinct clades or sub-clades have been linked to human cases. The gradual genetic changes identified in the sub-clades have been attributed to copy errors by viral encoded polymerases that lack an editing function, thereby resulting in antigenic drift. We report here the concurrent acquisition of the same polymorphism by multiple, genetically distinct, clade 2.2 sub-clades in Egypt, Russia, and Ghana. These changes are not easily explained by the current theory of “random mutation” through copy error, and are more easily explained by recombination with a common source. This conclusion is supported by additional polymorphisms shared by clade 2.2 isolates in Egypt and Germany

Aggregation of Single Nucleotide Polymorphisms in a Human H5N1 Clade 2.2 Hemagglutinin

The evolution of H5N1 has attracted significant interest 1-4 due to linkages with avian 5,6 and human infections 7,8. The basic tenets of influenza genetics 9 attribute genetic drift to replication errors caused by a polymerase complex that lacks a proof reading function. However, recent analysis 10 of swine influenza genes identifies regions copied with absolute fidelity for more than 25 years. In addition, polymorphism tracing of clade 2.2 H5N1 single nucleotide polymorphisms identify concurrent acquisition 11 of the same polymorphism onto multiple genetic backgrounds in widely dispersed geographical locations. Here we show the aggregation of regional clade 2.2 polymorphisms from Germany, Egypt, and sub-Sahara Africa onto a human Nigerian H5N1 hemagglutinin (HA), implicating recombination in the dispersal and aggregation of single nucleotide polymorphisms from closely related genomes

Perceptual and acoustic correlates of DBS of subthalamic nucleus versus globus pallidus interna for IPD : a comparative pilot study

Purpose: This study compared bilateral deep brain stimulation (DBS) in subthalamic nucleus (STN) versus globus pallidus interna (GPI) on perceived Speech Severity in Parkinson’s disease. Methods: 12 individuals with STN-DBS and 8 individuals with GPI-DBS were audio-recorded with DBS ON and OFF while reading an excerpt from the Rainbow Passage and producing a conversational monologue. Using a within-speaker, paired comparison paradigm, 10 listeners judged Speech Severity for pairs of stimulation ON-OFF (and OFF-ON) reading passages and monologues masked to stimulation status and speaker group. The proportion of trials for which ON versus OFF stimuli in a given pair was judged to be less severe was calculated. Results: There was a task effect, with significant results for Rainbow Passage but not conversational monologue. Perceived Speech Severity differed with stimulation status for GPI-DBS but not STN-DBS, with a greater proportion of ON stimulation speech samples judged to be less severe versus OFF samples. At the participant level, response to ON/OFF stimulation was highly variable in STN-DBS group. Discussion: DBS stimulation differentially impacts perceived speech severity for STN-DBS and GPI-DBS. Results further suggest the perceptual benefit of DBS stimulation may be task specific

Aggregation of Single Nucleotide Polymorphisms in a Human H5N1 Clade 2.2 Hemagglutinin

The rapid evolution of the H5N1 serotype of avian influenza has been explained by a mechanism involving the selection of single nucleotide polymorphisms generated by copy errors. The recent emergence of H5N1 Clade 2.2 in fifty countries, offered a unique opportunity to view the acquisition of new polymorphism in these evolving genomes. We analyzed the H5N1 hemagglutinin gene from a fatal human case from Nigeria in 2007. The newly emerged polymorphisms were present in diverse H5N1 isolates from the previous year. The aggregation of these polymorphisms from clade 2.2 sub-clades was not supported by recent random mutations, and was most easily explained by recombination between closely related sequences

N-Myc-induced metabolic rewiring creates novel therapeutic vulnerabilities in neuroblastoma

N-Myc is a transcription factor that is aberrantly expressed in many tumor types and is often correlated with poor patient prognosis. Recently, several lines of evidence pointed to the fact that oncogenic activation of Myc family proteins is concomitant with reprogramming of tumor cells to cope with an enhanced need for metabolites during cell growth. These adaptions are driven by the ability of Myc proteins to act as transcriptional amplifiers in a tissue-of-origin specific manner. Here, we describe the effects of N-Myc overexpression on metabolic reprogramming in neuroblastoma cells. Ectopic expression of N-Myc induced a glycolytic switch that was concomitant with enhanced sensitivity towards 2-deoxyglucose, an inhibitor of glycolysis. Moreover, global metabolic profiling revealed extensive alterations in the cellular metabolome resulting from overexpression of N-Myc. Limited supply with either of the two main carbon sources, glucose or glutamine, resulted in distinct shifts in steady-state metabolite levels and significant changes in glutathione metabolism. Interestingly, interference with glutamine-glutamate conversion preferentially blocked proliferation of N-Myc overexpressing cells, when glutamine levels were reduced. Thus, our study uncovered N-Myc induction and nutrient levels as important metabolic master switches in neuroblastoma cells and identified critical nodes that restrict tumor cell proliferation

“It will always continue unless we can change something”: consequences of intimate partner violence for indigenous women, children, and families

Background: Violence against indigenous women and girls is endemic, yet the absence of research on the consequences of this violence from the perspectives of women presents a profound barrier to the development of knowledge, along with violence prevention and mitigation. Although family is central to many indigenous communities, existing research typically examines the consequences of intimate partner violence (IPV) on women or children in isolation, rather than examining its consequences holistically. Objective: The purpose of this article is to identify US indigenous women's perspectives about the impact of IPV on women, children, and families. Method: Data were collected with 29 indigenous women affected by violence from a Southeastern tribe in the United States. As part of a larger critical ethnography, pragmatic horizon analysis of life history interviews revealed the consequences of IPV across multiple levels. Results: Women reported profound psychological consequences resulting from IPV. The majority of women had witnessed IPV in their childhood, providing support for an intergenerational cycle of violence. Women reported psychological consequences on children, which paralleled those reported by women, leaving deep impressions on children across their life course. Consequences on children and whole families were extensive, indicating the negative ramifications of IPV transcended personal boundaries and affected children and families across multiple generations. Conclusions: Given the tight-knit nature of indigenous families and communities, the consequences across individuals and families were noteworthy. However, a dearth in research examining consequences of IPV across levels fails to capture the interconnections of consequences for women, children, and families. Given the centrality of family in many indigenous communities, examining IPV from a holistic perspective that incorporates multiple levels is recommended for IPV research and intervention development