10 research outputs found

    The comparative responsiveness of Hospital Universitario Princesa Index and other composite indices for assessing rheumatoid arthritis activity

    Get PDF
    Objective To evaluate the responsiveness in terms of correlation of the Hospital Universitario La Princesa Index (HUPI) comparatively to the traditional composite indices used to assess disease activity in rheumatoid arthritis (RA), and to compare the performance of HUPI-based response criteria with that of the EULAR response criteria. Methods Secondary data analysis from the following studies: ACT-RAY (clinical trial), PROAR (early RA cohort) and EMECAR (pre-biologic era long term RA cohort). Responsiveness was evaluated by: 1) comparing change from baseline (Delta) of HUPI with Delta in other scores by calculating correlation coefficients; 2) calculating standardised effect sizes. The accuracy of response by HUPI and by EULAR criteria was analyzed using linear regressions in which the dependent variable was change in global assessment by physician (Delta GDA-Phy). Results Delta HUPI correlation with change in all other indices ranged from 0.387 to 0.791); HUPI's standardized effect size was larger than those from the other indices in each database used. In ACT-RAY, depending on visit, between 65 and 80% of patients were equally classified by HUPI and EULAR response criteria. However, HUPI criteria were slightly more stringent, with higher percentage of patients classified as non-responder, especially at early visits. HUPI response criteria showed a slightly higher accuracy than EULAR response criteria when using Delta GDA-Phy as gold standard. Conclusion HUPI shows good responsiveness in terms of correlation in each studied scenario (clinical trial, early RA cohort, and established RA cohort). Response criteria by HUPI seem more stringent than EULAR''s

    THEORY AND APPLICATION TO THE US MILITARY

    No full text
    An ever-growing share of defence R&D expenditures is being dedicated to the development and fielding of integrative technologies that enable separate individual systems to work in a coordinated and synergistic fashion as a single system. This study explores the optimal defence budget allocation to the development and acquisition of weapon systems and to the development of integrative technologies. We develop a suitable optimization framework, and then use it to derive the optimal budget allocation and analyse its properties. Finally, we use US defence budget data to calibrate the parameters of the model and provide a quantitative measure for the apparent US military supremacy.Research and Development, Integrative technologies, Budget allocation,

    p53 and Multidrug Resistance Transporters in the Central Nervous System

    No full text

    Current perspectives in gliomas

    No full text

    Tubulin interacting agents

    No full text

    Cell cycle regulators: mechanisms and their role in aetiology, prognosis, and treatment of cancer

    No full text
    corecore