Cognitive functioning and health related quality of life in patients with primary antiphospholipid syndrome

Section A: This paper reviews the literature surrounding cognitive functioning in patients with Antiphospholipid syndrome (APS) in the context of quality of life as an indicator of adaptation to chronic illness. The review focuses on cognitive functioning in APS patients and related clinical populations, describing and critiquing the empirical research literature exploring the evidence for cognitive deficits in these populations. Psychological theories of adaptation to chronic illness are discussed in relation to the concept of quality of life and research examining the relationship between cognitive dysfunction in APS and related clinical populations and health- related quality of life (HRQoL) is summarised. The limitations of previous research examining these factors are highlighted, demonstrating the need for empirical studies that address cognitive functioning and quality of life in patients with primary APS (PAPS). Section B: Objective: To explore the relationship between cognitive functioning and health related quality of life (HRQoL) in patients with PAPS. Method: Cross sectional comparisons of PAPS patients (PAPS thrombosis; n = 15; PAPS pregnancy; n = 15) and healthy controls (n = 15) on a battery of neuropsychological assessments and a measure of HRQoL. Results: PAPS thrombosis patients were twice as likely to be designated as cognitively impaired compared to PAPS pregnancy patients. PAPS thrombosis patients demonstrated lower performance on measures of memory and executive functioning compared to controls. PAPS pregnancy patients also performed more poorly on these measures compared to controls although not significantly. Both groups demonstrated poor HRQoL across physical and mental subscales. Both groups were significantly more impaired in all physical domains and one mental domain of HRQoL compared to controls. Neuropsychological outcomes in general intellectual abilities, memory and executive functioning were significantly associated with mental HRQoL subscales in PAPS thrombosis and executive functioning and memory were significantly associated with physical HRQoL subscales in PAPS pregnancy. Conclusions: Cognitive impairment is associated with and is more prevalent in PAPS thrombosis patients when compared with PAPS pregnancy patients. Both PAPS groups demonstrate poor HRQoL which is associated with executive functioning and memory. Section C: The critical review is structured to address four specific questions providing a reflective account of how the involvement in this project has contributed to the researcher’s skills and abilities and highlighted areas where further learning is necessary. The review also discusses further clinical applications and research for cognitive functioning and HRQoL in patients with PAPS

To Survive Ravensbrück: Considerations on Museum Pedagogy and the Passing on of Holocaust Remembrance

How can museums pass on the remembrances of the survivors of Holocaust in ways that engage visitors? This article looks at the ways museums remember the Holocaust by focusing on an exhibition entitled To Survive - Voices from Ravensbrück at the museum of cultural history, Kulturen, in Lund, Sweden. The exhibition centres on a unique collection of small objects secretly and illegally created by women in the Ravensbrück concentration camp as acts of resistance against the inhuman conditions in the camp. Exhibits on the Holocaust represent a particular tradition of museum pedagogy, associated with the imperative of ‘never again’, often read as an attempt to evoke empathy and responsibility for other human beings. In line with this tradition, the educational aim of To Survive is to encourage the viewers, to be moved to a greater sense of responsibility. The article provides a detailed description of the exhibit, discusses the choice of the museum to tone down the dark aspects of the story, and looks into how the exhibition realizes various appeals to the visitor, but also how it makes some voices mute. As such this article contributes to the ongoing museological discussions of the complexities of putting so-called difficult knowledge on display.Key Words: Museum Pedagogy, Visual Pedagogy, Memory Studies, Holocaust Studies, Difficult Knowledge, Ethical responsibility, Visitor involvement

THE RESIDENT AND THE ORTHOPAEDIC TEAM

The physiotherapist is an essential member of any orthopaedic team

Letter from W. S. Tinning to John Muir, 1912 Sep 13.

W. S. TINNINGATTORNEY AT LAWMARTINEZ, CAL.Martinez, Cal., Sept. 13th,1912.Mr. John Muir, Martinez, Cal. Dear Mr. Muir: The commissioner’s deed for the church property at Valona was delivered and recorded September 12th, and I, at the same time, delivered to Pezzuto your deed of the same property to him. I then cashed the One Thousand Dollar check and paid out of it the expenses of the commissioner’s deed and of recording the same, also the cost of drawing your deed to Pezzuto, and deposited the balance amounting to $994,00 to your credit in the Bank of Martinez. You will find enclosed the Bank deposit tag for the amount above stated. You will also find enclosed memorandum receipt of the expenses above referred to.Yours vary truly,[illegible]05274 TELEPHONE RED 41W.S.TINNINGATTORNEY AND COUNSELOR AT LAW,MARTINEZ,CAL.Paid for comminssioner\u27s deed, 12.00Recording commissioner\u27s deed, 1.50Drawing deed from Muir to Pezzuto 2.50Total 16.00Paid-W.S. [illegible]Received$1000.00Expenses 6.00Balance $994,00 0527

When feminist ideas are hijacked: how the demand for men to take up child care responsibilities impacts formal child care policy

Second wave feminists called for a more equal and just society. They demanded the recognition of issues that were traditionally off the political agenda – so called women's issues – from domestic violence, contraception and access to safe abortion to affordable quality child care. Today policy discussions about issues that directly impact women's lives are carefully couched in gender-neutral language. The impact of policy on women's lives is rendered invisible by the disappearance of 'women' into 'people', 'parents' and 'families'. Formal child care policy is an example of a public policy that continues to resolutely ignore the different lives of men and women. This paper presents qualitative data gathered from women in northern regional Australia, interviewed in two research studies in 2007 and 2009/10. Women spoke of their search for quality long day care in a complex and rapidly changing child care landscape. From this data we argue that child care is no longer seen as a women's issue, diverting the public gaze from women's very real struggles in this so-called time of 'choice' and equality. Was this what feminists called for when we demanded men share the responsibility of raising children

New optical techniques and hardware for studying live cell dynamics

This thesis was previously held under moratorium from 12/02/2019 to 21/05/2021.Fluorescence optical microscopy has become an integral technique in the life sciences and has opened the door to investigating live biological specimens non-invasively at sub-cellular spatial resolutions with high specificity and temporal resolutions. One of the limiting factors of optical microscopy is that the spatial resolution is dictated by the diffraction limit of light.;This work shows the first use of LEDs to carry out widefield axial super-resolution standing wave microscopy with high temporal resolution. The technique was used to image red blood cell membrane dynamics in real time with no increase in photobleaching or toxicity rates compared to standard widefield imaging. This work also presents 3D computational reconstructions of the data allowing for easier visualisation and the possibility of carrying out further quantitative analysis.;Following on from Chapter 2, is an investigation into the development and application of multi-wavelength standing wave microscopy on live specimens in both emission and excitation modalities. These techniques are henceforth referred to in this thesis as TartanSW. This investigation found that using multiple excitation wavelengths allowed for a reduction in the nodal contribution of the images resulting in obtaining 32.3 % more spatial information about the structure of the specimen. It is also shown that by taking the difference images between each excitation channel the standing wave antinodal planes could be reduced in thickness enabling axial resolutions on the order of 55 nm when imaging live cell experiments.;The multi-emission technique was shown that it could be applied to be applied to imaging biological specimens using both widefield and confocal microscopy. However, the widefield data was not in line with the expected theoretical structure. There is the possibility of using plane ordering though to infer the directionality of a specimen structure and extract height maps though further work to develop computational tools to enable this will have to be implemented.;Finally, this thesis describes the work carried out making use of a new high-brightness 340 nm LED to develop a fast switching 340/380 nm illuminator and demonstrate its application for ratiometric Fura-2 Ca2+ imaging of live cell specimens with sub-5 nM precision that supports full frame video-rate temporal resolutions.Fluorescence optical microscopy has become an integral technique in the life sciences and has opened the door to investigating live biological specimens non-invasively at sub-cellular spatial resolutions with high specificity and temporal resolutions. One of the limiting factors of optical microscopy is that the spatial resolution is dictated by the diffraction limit of light.;This work shows the first use of LEDs to carry out widefield axial super-resolution standing wave microscopy with high temporal resolution. The technique was used to image red blood cell membrane dynamics in real time with no increase in photobleaching or toxicity rates compared to standard widefield imaging. This work also presents 3D computational reconstructions of the data allowing for easier visualisation and the possibility of carrying out further quantitative analysis.;Following on from Chapter 2, is an investigation into the development and application of multi-wavelength standing wave microscopy on live specimens in both emission and excitation modalities. These techniques are henceforth referred to in this thesis as TartanSW. This investigation found that using multiple excitation wavelengths allowed for a reduction in the nodal contribution of the images resulting in obtaining 32.3 % more spatial information about the structure of the specimen. It is also shown that by taking the difference images between each excitation channel the standing wave antinodal planes could be reduced in thickness enabling axial resolutions on the order of 55 nm when imaging live cell experiments.;The multi-emission technique was shown that it could be applied to be applied to imaging biological specimens using both widefield and confocal microscopy. However, the widefield data was not in line with the expected theoretical structure. There is the possibility of using plane ordering though to infer the directionality of a specimen structure and extract height maps though further work to develop computational tools to enable this will have to be implemented.;Finally, this thesis describes the work carried out making use of a new high-brightness 340 nm LED to develop a fast switching 340/380 nm illuminator and demonstrate its application for ratiometric Fura-2 Ca2+ imaging of live cell specimens with sub-5 nM precision that supports full frame video-rate temporal resolutions

Hearing parent's voices: choosing quality long day care in northern regional Australia

The last decade saw the rise and collapse of Australia's largest for-profit child care provider. Policy makers assumed that the for-profit sector would ensure a 'market' that provided a wider range of child care choice, and increased opportunities for accessing quality long day care. However, in rural and regional areas, the idea of 'choice' is necessarily limited by what is available within a practical distance. With smaller populations and less likelihood of profit making economies of scale, choice has been reduced to an idea of 'luck', if indeed parents are able to find a vacancy in their child care service of 'choice'. This paper presents qualitative data gathered from 70 parents in Northern Regional Australia, interviewed in two research studies in 2007 and 2009. Parents from Darwin, Cairns, Townsville and Mackay spoke of their search for quality long day care in a complex and rapidly changing child care landscape. For Indigenous and non-Indigenous parents the role child care played in their lives went far beyond an educational tool or child minding service. In communities often characterised by distance from friends and family, fluctuating economic growth and limited services for those outside the mainstream community, quality child care can offer the hub of 'community' that many families seek. At this critical time of child care policy change this research draws on the voices of parents to explore the interplay between conceptions of family, and ideas of choice, quality and the market mechanism

Standing wave microscopy of red blood cell membrane morphology with high temporal resolution

Widefield fluorescence microscopy is an integral tool for life science imaging though the achievable resolutions are limited by the diffraction nature of light. One technique to increase the axial resolution is known as standing wave microscopy [1]. The standing wave can be generated by placing a mirror at the specimen plane which causes interference between the incoming and reflected excitation illumination. The axial resolution is reduced to λ/4n as only fluorophores which are in the location of the full width at the half maximum of the antinodes are excited [2] resulting in periodic bands of fluorescence

Co-designing wellbeing: the commonality of needs between co-designers and mental health service users

This paper considers the potential impact of the co-design process on the wellbeing of stakeholders involved in mental health service design. The findings presented here are drawn from semi-structured interviews conducted with both co-designers of a perinatal mental health service, who previously had issues with their mental health and acted as experts by experience, and the service users who accessed the designed offer. These have subsequently been analysed using a General Inductive Analysis approach (Thomas, 2006) to understand the factors that impacted on a participant’s wellbeing in both circumstances. Our findings highlight that there are similarities between the factors that impacted on the wellbeing of the co-designers and those that impacted on the wellbeing of service users accessing a mental health service. This paper suggests ways in which the design community might learn from the mental health sector to manage, and potentially improve, co-designers’ wellbeing during the co-design process. It also suggests how the role of the designer might need to expand to explicitly consider and manage the wellbeing of co-designers during a project

One woman's nation : Pauline Hanson, femininity and right wing populism in Australia

In the 1990's the most powerful right-wing populist party in Australian history, One Nation Party , was formed and led by Pauline Hanson. Populist parties, like Pauline Hanson's One Nation , have traditionally been a masculine domain yet Hanson masterfully gained support for her views by deploying the powerful rhetoric of home and family. This thesis illuminates Hanson's use of traditional notions of femininity such as mother, care-giver, and teacher in her speeches and charts the way that these gendered representations shaped key policy issues on multi-culturalism, immigration, globalisation and the family. This discourse helped Hanson articulate a politics of resentment which appealed to a constituency comprised, primarily, of "white" Australian men displaced from their traditional place of social, cultural and political privilege. To gain a greater understanding of Hanson's discursive manoeuvres, an examination of letters written by women to the editors of major Australian newspapers was undertaken. This media analysis reveals how this domestic discourse was adopted by women who supported Hanson and by women who were opposed to Hanson's racially-based views. This thesis indicates how women who opposed Hanson negotiated her domestic rhetoric to counter to her policies