Regenerative Glycosylation

Previously, we communicated 3,3-difluoroxindole (HOFox)-mediated glycosylations wherein 3,3-difluoro-3<i>H</i>-indol-2-yl (OFox) imidates were found to be key intermediates. Both the in situ synthesis from the corresponding glycosyl bromides and activation of the OFox imidates could be conducted in a regenerative fashion. Herein, we extend this study to the synthesis of various glycosidic linkages using different sugar series. The main outcome of this study relates to enhanced yields and/or reduced reaction times of glycosylations. The effect of HOFox-mediated reactions is particularly pronounced in case of unreactive glycosyl donors and/or glycosyl acceptors. A multistep regenerative synthesis of oligosaccharides is also reported

Additional file 1 of Nanoscale myelinogenesis image in developing brain via super-resolution nanoscopy by near-infrared emissive curcumin-BODIPY derivatives

Additional file 1. Additional synthesis and characterization of MyL-1, MyL-2, and MyL-3 (Fig. S1-Fig. S6). Molecular orbital energy of MyL (Fig. S7). Sphingomyelins bilayer interaction with MyL (Fig. S8). Cytotoxicity data results of MyL-1, MyL-2 and MyL-3 (Fig. S9). Photostability evaluation of MyL-1 (Fig. S10). Confocal, and its magnified 3D-STED images of tissue sections treated with MyL-1 (Fig. S11-Fig. S14) and Corresponding photophysical data (Table S1)