Correlation between demography and histopathology with recurrence.

<p>^<b>a</b><b>Pearson Chi-square test.</b></p><p>^<b>b</b><b>Mann-Whitney U test.</b></p><p>CKC, cold knife conization; LEEP, loop electrosurgical excision procedure; CIN, cervical intraepithelial neoplasia; HPV, human papilloma virus.</p

Number of quadrants involvement and depth of gland involvement in CIN.

<p>^<b>a</b><b>Pearson Chi-square test.</b></p><p>^<b>b</b><b>Monte Carlo exact test.</b></p><p>^<b>c</b><b>Mann-Whitney U test.</b></p><p>CIN, cervical intraepithelial neoplasia; QI, quadrants involvement; GI, gland involvement; NA, not applicable.</p

Characteristics of patients having LEEP/CKC (matched pairs).

<p>^<b>a</b><b>Mann-Whitney U test.</b></p><p>^<b>b</b><b>Pearson Chi-square test.</b></p><p>^<b>c</b><b>Monte Carlo exact test.</b></p><p>^<b>d</b><b>not the matched factor.</b></p><p>CKC, cold knife conization; LEEP, loop electrosurgical excision procedure; CIN, cervical intraepithelial neoplasia; HPV, human papilloma virus.</p

Representive pictures of immunohistochemical staining of TPX2, IMP3, and PD-L1 in cervical tissues.

<p>Negative controls used non-immune isotype serum instead of primary antibodies. Arrows indicate the positively stained cells. Scale bars, 50 μm; original magnification, x200.</p

Persistence/recurrence-free rate of women after cervical conization.

<p>The patients were divided into three groups according to surgical margin and HPV status.</p

Allred score of immunohistochemical staining.

<p>^<b>a</b><b>Mann-Whitney U test.</b></p><p>^<b>b</b><b>Pearson Chi-square test.</b></p><p>CIN, cervical intraepithelial neoplasia; TPX2, xenopus kinesin-like protein 2; IMP3,insulin-like growth factor II messenger RNA (mRNA)-binding protein 3; PD-L1,programmed cell death-1 ligand-1.</p