Associations of C-reactive Protein (CRP) with Carotid Intima-media Thickness (CIMT) Obtained from the Instrumental Variables Analysis in Which <i>CRP</i> Haplotypes Act as An Instrument for the Non-confounded and Unbiased Effect of CRP.

<p>Associations of C-reactive Protein (CRP) with Carotid Intima-media Thickness (CIMT) Obtained from the Instrumental Variables Analysis in Which <i>CRP</i> Haplotypes Act as An Instrument for the Non-confounded and Unbiased Effect of CRP.</p

Associations Between Serum C-reactive Protein (CRP) Measured at Two Time Points and Carotid Intima-media Thickness (CIMT) Obtained from Standard Multivariable Regression Analysis.

<p>Only participants with no missing data in any of the covariates are included.</p>*<p>Adjusted for age, sex, systolic blood pressure, diastolic blood pressure, HDL-cholesterol, LDL-cholesterol, triglycerides, body mass index, smoking, physical inactivity, and low occupational status.</p

Participant Characteristics.

*<p>Low occupational status refers to clerical position in a three level hierarchy of administrative, professional and clerical employment grade.</p>†<p>Measured at mean age of 49.2 (SD = 6.0) years</p

Association Between 4 <i>CRP</i> Haplotypes and Serum C-reactive Protein (CRP) Concentration.

*<p>Adjusted for age and sex.</p

Contemporaneous Associations of Risk Factors with Serum C-reactive Protein (CRP) Concentration and Carotid Intima-media Thickness (CIMT) at Mean Age 61.0 Years^*.

*<p>Based on age- and sex-adjusted linear regression models.</p>†<p>Binary variables: 0 = never smoker, 1 = ever smoker; 0 = non-sedentary, 1 = sedentary; 0 = non-manual, 1 = manual.</p

Meta-analysis association results for hemoglobin in unconditional and conditional analyses in the <i>ABO</i> locus.

<p>Regional plots show (A) unconditional analysis and analysis conditional on (B) O, (C) AO, (D) AA, (E) B and (F) AB blood group haplotype. The most significant SNP in the unconditional analysis, rs507666, is highlighted throughout to facilitate comparison of results. The color coding of the LD between the SNPs ranges from dark blue for r² = 0–0.2 to red for r² = 0.8–1, and is grey where LD information was not available. Blue line represents suggestive and red line significant threshold.</p

Comparison of the effect sizes on 15 <i>ABO</i> SNPs between eight different traits.

<p>Traits include von Willebrand factor (log transformed, logVWF) and factor VIII (FVIII) for coagulation factors, total cholesterol (TC) and low-density lipoprotein (LDL) for lipids, hemoglobin (Hb), red blood cell count (RCC) and hematocrit (Hct) for the red blood cell (RBC) traits and alkaline phosphatase (log transformed, logALP) for liver marker group. The colored bar for each SNP represents the 95% confidence interval of the effect size.</p

Manhattan plots of meta-analysis association results in unconditional and conditional analyses for hemoglobin (Hb), hematocrit (Hct) and red blood cell count (RCC).

<p>Results show unconditional analysis for all three traits (top row) and analysis of Hb conditional on (A) Hct and (B) RCC, of Hct conditional on (C) Hb and (D) RCC and of RCC conditional on (E) Hb and (F) Hct. Line at–log₁₀(<i>P</i> value) = 5.3 represents suggestive threshold and line at–log₁₀(<i>P</i> value) = 7.3 significant threshold.</p

One-way analysis of variance in hemoglobin (Hb), hematocrit (Hct) and red blood cell count (RCC) between different blood groups, as derived based on three SNP haplotypes.

<p>One-way analysis of variance in hemoglobin (Hb), hematocrit (Hct) and red blood cell count (RCC) between different blood groups, as derived based on three SNP haplotypes.</p

Study characteristics.

<p>Study characteristics.</p